A Critical Role for Transcription Factor Smad4 in T Cell Function that Is Independent of Transforming Growth Factor β Receptor Signaling
Tóm tắt
Từ khóa
Tài liệu tham khảo
Artavanis-Tsakonas, 1999, Notch signaling: cell fate control and signal integration in development, Science, 284, 770, 10.1126/science.284.5415.770
Attisano, 2002, Signal transduction by the TGF-beta superfamily, Science, 296, 1646, 10.1126/science.1071809
Bierie, 2006, Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer, Nat. Rev. Cancer, 6, 506, 10.1038/nrc1926
Cazac, 2000, TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo, Immunity, 13, 443, 10.1016/S1074-7613(00)00044-3
Chen, 2003, Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3, J. Exp. Med., 198, 1875, 10.1084/jem.20030152
Chu, 2004, Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo, Development, 131, 3501, 10.1242/dev.01248
Chytil, 2002, Conditional inactivation of the TGF-beta type II receptor using Cre:Lox, Genesis, 32, 73, 10.1002/gene.10046
Derynck, 2003, Smad-dependent and Smad-independent pathways in TGF-beta family signalling, Nature, 425, 577, 10.1038/nature02006
Fridlender, 2009, Polarization of tumor-associated neutrophil phenotype by TGF-beta: “N1” versus “N2” TAN, Cancer Cell, 16, 183, 10.1016/j.ccr.2009.06.017
Gorelik, 2001, Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells, Nat. Med., 7, 1118, 10.1038/nm1001-1118
Gu, 2012, Requirements of transcription factor Smad-dependent and -independent TGF-β signaling to control discrete T-cell functions, Proc. Natl. Acad. Sci. USA, 109, 905, 10.1073/pnas.1108352109
Hahn, 2011, Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice, J. Clin. Invest., 121, 4030, 10.1172/JCI45114
He, 2006, Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway, Cell, 125, 929, 10.1016/j.cell.2006.03.045
Howe, 1998, Mutations in the SMAD4/DPC4 gene in juvenile polyposis, Science, 280, 1086, 10.1126/science.280.5366.1086
Ishigame, 2013, Excessive Th1 responses due to the absence of TGF-β signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis, Proc. Natl. Acad. Sci. USA, 110, 6961, 10.1073/pnas.1304498110
Kim, 2006, Smad4 signalling in T cells is required for suppression of gastrointestinal cancer, Nature, 441, 1015, 10.1038/nature04846
Konkel, 2011, Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-β, Nat. Immunol., 12, 312, 10.1038/ni.1997
Laouar, 2005, Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma, Nat. Immunol., 6, 600, 10.1038/ni1197
Lee, 2001, A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival, Immunity, 15, 763, 10.1016/S1074-7613(01)00227-8
Li, 2006, Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms, Immunity, 25, 455, 10.1016/j.immuni.2006.07.011
Li, 2006, Transforming growth factor-beta regulation of immune responses, Annu. Rev. Immunol., 24, 99, 10.1146/annurev.immunol.24.021605.090737
Lim, 2006, Smad4 cooperates with lymphoid enhancer-binding factor 1/T cell-specific factor to increase c-myc expression in the absence of TGF-beta signaling, Proc. Natl. Acad. Sci. USA, 103, 18580, 10.1073/pnas.0604773103
Liu, 2008, A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells, Nat. Immunol., 9, 632, 10.1038/ni.1607
Marie, 2005, TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells, J. Exp. Med., 201, 1061, 10.1084/jem.20042276
Marie, 2006, Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor, Immunity, 25, 441, 10.1016/j.immuni.2006.07.012
Massagué, 1998, TGF-beta signal transduction, Annu. Rev. Biochem., 67, 753, 10.1146/annurev.biochem.67.1.753
Miyaki, 2003, Role of Smad4 (DPC4) inactivation in human cancer, Biochem. Biophys. Res. Commun., 306, 799, 10.1016/S0006-291X(03)01066-0
Nie, 2012, c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells, Cell, 151, 68, 10.1016/j.cell.2012.08.033
Rubtsov, 2007, TGFbeta signalling in control of T-cell-mediated self-reactivity, Nat. Rev. Immunol., 7, 443, 10.1038/nri2095
Shi, 2003, Mechanisms of TGF-beta signaling from cell membrane to the nucleus, Cell, 113, 685, 10.1016/S0092-8674(03)00432-X
Shull, 1992, Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease, Nature, 359, 693, 10.1038/359693a0
Staal, 2008, WNT signalling in the immune system: WNT is spreading its wings, Nat. Rev. Immunol., 8, 581, 10.1038/nri2360
Takimoto, 2010, Smad2 and Smad3 are redundantly essential for the TGF-beta-mediated regulation of regulatory T plasticity and Th1 development, J. Immunol., 185, 842, 10.4049/jimmunol.0904100
Wahl, 2006, TGF-beta: a mobile purveyor of immune privilege, Immunol. Rev., 213, 213, 10.1111/j.1600-065X.2006.00437.x
Wang, 2011, The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation, Immunity, 35, 871, 10.1016/j.immuni.2011.09.021
Weber, 2011, A critical role for TCF-1 in T-lineage specification and differentiation, Nature, 476, 63, 10.1038/nature10279
Welniak, 2007, Immunobiology of allogeneic hematopoietic stem cell transplantation, Annu. Rev. Immunol., 25, 139, 10.1146/annurev.immunol.25.022106.141606
Yang, 2008, Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis, Cancer Cell, 13, 23, 10.1016/j.ccr.2007.12.004
Yang, 2008, Molecular antagonism and plasticity of regulatory and inflammatory T cell programs, Immunity, 29, 44, 10.1016/j.immuni.2008.05.007
Yang, 2010, TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression, Trends Immunol., 31, 220, 10.1016/j.it.2010.04.002
Yingling, 2004, Development of TGF-beta signalling inhibitors for cancer therapy, Nat. Rev. Drug Discov., 3, 1011, 10.1038/nrd1580
Yoshioka, 2012, Differential effects of inhibition of bone morphogenic protein (BMP) signalling on T-cell activation and differentiation, Eur. J. Immunol., 42, 749, 10.1002/eji.201141702