A Comparative Analysis of Antibiotic Usage in Diabetic Foot Infections Against Healing Time

World Health Organization. Global report on diabetes. Available at: https://apps.who.int/iris/bitstream/handle/10665/204871/9789241565257_eng.pdf;jsessionid=99B6D6F352DBE0A7ABE8E6B37070055A?sequence=1. Accessed January 17, 2020. World Health Organization. Diabetes. Data and statistics. Available at: http://www.euro.who.int/en/health-topics/noncommunicable-diseases/diabetes/data-and-statistics. Accessed January 17, 2020. Raport. Cukrzyca, ukryta pandemia 2014. Available at: http://www.pfed.org.pl/uploads/1/9/9/8/19983953/cukrzycaukrytapandemia2014.pdf. Accessed January 17, 2020. Reveles, 2016, Epidemiology of methicillin-resistant Staphylococcus aureus diabetic foot infections in a large academic hospital: implications for antimicrobial stewardship, PLoS One, 24, 1 Korzon-Burakowska, 2008, Zespół stopy cukrzycowej – patogeneza i praktyczne aspekty postępowania, Forum Medycyny Rodzinnej, 2, 234 Yasin, 2018, Baseline characteristics of infected foot ulcers in patients with diabetes at a tertiary care hospital in Pakistan, J Wound Care, 27, 26, 10.12968/jowc.2018.27.Sup10.S26 Jawień, 2012, Wytyczne postępowania miejscowego i ogólnego w ranach objętych procesem infekcji, Leczenie Ran, 9, 59 Bartoszewicz, 2012, Biofilm based wound care: strategy for the treatment of chronic wounds affected by the infection caused by microorganisms in the form of biofilms, Leczenie Ran, 9, 1 White, 2008, Critical colonisation of chronic wounds: microbial mechanisms, WoundsUK, 4, 70 Lipsky, 2012, Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections, Clin Infect Dis, 54, e132, 10.1093/cid/cis346 Lipsky BA, Senneville E, Abbas ZG, Sanchez JA, Diggle M, Embil JM, Kono S, Lavery LA, Malone M, van Asten SA, Urbancic- Rovan V, Peters EJG.. International Working Group on the diabetic foot guideline on the diagnosis and treatment of foot infection in persons with diabetes. Available at: https://iwgdfguidelines.org/wp-content/uploads/2019/05/05-IWGDF-infection-guideline-2019.pdf. Accessed June 24, 2019. Banu, 2015, Spectrum of bacteria associated with diabetic foot ulcer and biofilm formation: a prospective study, Australas Med J, 8, 280, 10.4066/AMJ.2015.2422 Kee, 2019, Risk factor analysis on the healing time and infection rate of diabetic foot ulcers in a referral wound care clinic, J Wound Care, 28, S4, 10.12968/jowc.2019.28.Sup1.S4 Wlash, 2000, Molecular mechanisms that confer antibacterial drug resistance, Nature, 406, 775, 10.1038/35021219 Malik, 2013, The diabetic foot infections: biofilms and antimicrobial resistance, Diabetes Metab Syndr, 7, 101, 10.1016/j.dsx.2013.02.006 The European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters, version 9.0, 2019. Available at: http://www.eucast.org/clinical_breakpoints/. Accessed March 11, 2020. Miriagou, 2013, Combined disc methods for the detection of KPC- and/or VIM-positive Klebsiella pneumoniae: improving reliability for the double carbapenemase producers, Clin Microbiol Infect, 19, E412, 10.1111/1469-0691.12238 Nordmann, 2012, Rapid detection of carbapenemase-producing Enterobacteriaceae, Emerg Infect Dis, 18, 1503, 10.3201/eid1809.120355 Paterson, 2005, Extended-spectrum β-lactamases: a clinical update, Clin Microbiol Rev, 18, 657, 10.1128/CMR.18.4.657-686.2005 The European Committee on Antimicrobial Susceptibility Testing The EUCAST guideline on detection of resistance mechanisms v1.0 (2013-12-11). Available at: http://www.eucast.org/resistance_mechanisms/. Accessed March 11, 2020. 2019 H Wickham (2017). tidyverse: Easily Install and Load the 'Tidyverse'. R package version 1.2.1. Available at: https://CRAN.R-project.org/package=tidyverse. Accessed March 11, 2020. Wickham, 2016 Małecki, 2014, Etiological factors of infections in diabetic foot syndrome – attempt to define optimal empirical therapy, Adv Clin Exp Med, 23, 39, 10.17219/acem/37020 Lipsky, 2004, Diagnosis and treatment of diabetic foot infections, Clin Infect Dis, 39, 885, 10.1086/424846 Lipsky, 2007, Empirical therapy for diabetic foot infections: are there clinical clues to guide antibiotic selection?, Clin Microbiol Infect, 13, 351, 10.1111/j.1469-0691.2007.01697.x Shanmugam, 2013, The bacteriology of diabetic foot ulcers, with a special reference to multidrug resistant strains, J Clin Diagn Res, 7, 441 Saseedharan, 2018, Epidemiology of diabetic foot infections in a reference tertiary hospital in India, Braz J Microbiol, 49, 401, 10.1016/j.bjm.2017.09.003 Vinodkumar, 2011, Isolation of bacteriophages to multi-drug resistant Enterococci obtained from diabetic foot: a novel antimicrobial agent waiting in the shelf?, Indian J Pathol Microbiol, 54, 90, 10.4103/0377-4929.77333 Warren, 2010, Medical therapy of diabetic foot infections, J Vasc Surg, 52, 67, 10.1016/j.jvs.2010.06.010 Barwell, 2017, Diabetes Action Group. Diabetic foot infection: antibiotic therapy and good practice recommendations, Int J Clin Pract, 71, 1, 10.1111/ijcp.13006 Rao, 2007, Optimising antimicrobial therapy in diabetic foot infections, Drugs, 67, 195, 10.2165/00003495-200767020-00003 Hryniewicz, 2012, Stosowanie antybiotyków w zakażeniach skóry i tkanek miękkich, Narodowy Program Ochrony Antybiotyków. Warszawa, 6 Lipsky, 2016, International Working Group on the Diabetic Foot, Peters EJG, IWGDF guidance on the diagnosis and management of foot infections in persons with diabetes, Diabetes Metab Res Rev, 32, 45, 10.1002/dmrr.2699 Tone, 2015, Six-week versus twelve-week antibiotic therapy for nonsurgically treated diabetic foot osteomyelitis: a multicenter open-label controlled randomized study, Diabetes Care, 38, 302, 10.2337/dc14-1514 Uckay, 2018, A randomized, controlled study to investigate the efficacy and safety of a topical gentamicin-collagen sponge in combination with systemic antibiotic therapy in diabetic patients with a moderate or severe foot ulcer infection, BMC Infect Dis, 18, 361, 10.1186/s12879-018-3253-z Marston, 2006, Risk factors associated 340 with healing chronic diabetic foot ulcers: the importance of hyperglycemia, Ostomy 341 Wound Manage, 52, 26 Zagozdzon, 2003, The aging of the immune system, Przegl Lek, 60, 156 Nigi, 2018, Fighting diabetic foot ulcers-the diabetologist: a king maker of the fight, Semin Vasc Surg, 31, 49, 10.1053/j.semvascsurg.2018.12.003 Pence, 2014, Exercise, obesity, and cutaneous wound healing: evidence from rodent and human studies, Adv Wound Care (New Rochelle), 3, 71, 10.1089/wound.2012.0377 Pierpont, 2014, Obesity and surgical wound healing: a current review, ISRN Obes, 2014