A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader

Cell Chemical Biology - Tập 25 Số 1 - Trang 88-99.e6 - 2018
Hai‐Tsang Huang1,2, Dennis Dobrovolsky1,2, Joshiawa Paulk3, Guang Yang4,3, Ellen Weisberg3, Zainab M. Doctor1,2, Dennis L. Buckley3, Joong-Heui Cho5, Eunhwa Ko5, Jaebong Jang1,2, Kun Shi6,7, Hwan Geun Choi5, James D. Griffin3,8, Ying Li6, Steven P. Treon4,3,8, Eric S. Fischer1,2, James E. Bradner3,8, Li Tan1,2,6, Nathanael S. Gray1,2
1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
2Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA
3Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115 USA
4Bing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA 02115, USA
5New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Korea
6Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China
7University of Chinese Academy of Sciences, Beijing, 100049, China
8Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

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