A BAF’ling Approach to Curing HIV

Conrad, 2017, The short isoform of BRD4 promotes HIV-1 latency by engaging repressive SWI/SNF chromatin-remodeling complexes, Mol. Cell, 67, 1001, 10.1016/j.molcel.2017.07.025 Hakre, 2011, Epigenetic regulation of HIV latency, Curr. Opin. HIV AIDS, 6, 19, 10.1097/COH.0b013e3283412384 Herrera, 2004, VP16-dependent association of chromatin-modifying coactivators and underrepresentation of histones at immediate-early gene promoters during herpes simplex virus infection, J. Virol., 78, 9689, 10.1128/JVI.78.18.9689-9696.2004 Kim, 2018, Getting the “kill” into “shock and kill”: strategies to eliminate latent HIV, Cell Host Microbe, 23, 14, 10.1016/j.chom.2017.12.004 Mahmoudi, 2006, The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter, J. Biol. Chem., 281, 19960, 10.1074/jbc.M603336200 Marian, 2018, Small molecule targeting of specific BAF (mSWI/SNF) complexes for HIV latency reversal, Cell Chem. Biol., 25, 1443, 10.1016/j.chembiol.2018.08.004 Mayes, 2014, ATP-dependent chromatin remodeling complexes as novel targets for cancer therapy, Adv. Cancer Res., 121, 183, 10.1016/B978-0-12-800249-0.00005-6 Rafati, 2011, Repressive LTR nucleosome positioning by the BAF complex is required for HIV latency, PLoS Biol., 9, e1001206, 10.1371/journal.pbio.1001206 Van Lint, 1996, Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation, EMBO J., 15, 1112, 10.1002/j.1460-2075.1996.tb00449.x Verdin, 1993, Chromatin disruption in the promoter of human immunodeficiency virus type 1 during transcriptional activation, EMBO J., 12, 3249, 10.1002/j.1460-2075.1993.tb05994.x