Aβ-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Aβ pathology

Akiyama, 2001, Immunohistochemical localization of neprilysin in the human cerebral cortex: inverse association with vulnerability to amyloid β-protein (Aβ) deposition, Brain Res., 902, 277, 10.1016/S0006-8993(01)02390-3 Back, 1989, Histochemical visualization of neutral endopeptidase-24.11 (enkephalinase) activity in rat brain: cellular localization and codistribution with enkephalins in the globus pallidus, J. Neurosci., 9, 4439, 10.1523/JNEUROSCI.09-12-04439.1989 Bajjalieh, 1994, Differential expression of synaptic vesicle protein 2 (SV2) isoforms, J. Neurosci., 14, 5223, 10.1523/JNEUROSCI.14-09-05223.1994 Binder, 1985, The distribution of tau in the mammalian central nervous system, J. Cell Biol., 101, 1371, 10.1083/jcb.101.4.1371 Borchelt, 1996, Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo, Neuron, 17, 1005, 10.1016/S0896-6273(00)80230-5 Borchelt, 1997, Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins, Neuron, 19, 939, 10.1016/S0896-6273(00)80974-5 Bornemann, 2001, Aβ-induced inflammatory processes in microglia cells of APP23 transgenic mice, Am. J. Pathol., 15, 63, 10.1016/S0002-9440(10)63945-4 Braak, 1991, Neuropathological staging of Alzheimer-related changes, Acta Neuropathol. (Berlin), 82, 239, 10.1007/BF00308809 Buckley, 1985, Identification of a transmembrane glycoprotein specific for secretory vesicles of neural and endocrine cells, J. Cell Biol., 100, 1284, 10.1083/jcb.100.4.1284 Buxbaum, 1998, Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path, J. Neurosci., 18, 9629, 10.1523/JNEUROSCI.18-23-09629.1998 Caceres, 1984, Differential subcellular localization of tubulin and the microtubule-associated protein MAP2 in brain tissue as revealed by immunocytochemistry with monoclonal hybridoma antibodies, J. Neurosci., 4, 394, 10.1523/JNEUROSCI.04-02-00394.1984 Calhoun, 1998, Hippocampal neuron and synaptophysin-positive bouton number in aging C57BL/6 mice, Neurobiol. Aging, 19, 599, 10.1016/S0197-4580(98)00098-0 Chishti, 2001, Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695, J. Biol. Chem., 276, 21562, 10.1074/jbc.M100710200 Crystal, 1982, Cortical substance P-like immunoreactivity in cases of Alzheimer's disease and senile dementia of the Alzheimer type, J. Neurochem., 38, 1781, 10.1111/j.1471-4159.1982.tb06665.x Davies, 1976, Selective loss of central cholinergic neurons in Alzheimer's disease, Lancet, 2, 1403, 10.1016/S0140-6736(76)91936-X Davies, 1980, Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementa, Nature, 288, 279, 10.1038/288279a0 Duff, 1996, Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1, Nature, 383, 710, 10.1038/383710a0 Eckman, 2001, Degradation of the Alzheimer's amyloid β peptide by endothelin-converting enzyme, J. Biol. Chem., 276, 24540, 10.1074/jbc.M007579200 Freund, 1996, Interneurons of the hippocampus, Hippocampus, 6, 347, 10.1002/(SICI)1098-1063(1996)6:4<347::AID-HIPO1>3.0.CO;2-I Fukuda, 1998, GABAergic axon terminals at perisomatic and dendritic inhibitory sites show different immunoreactivities against two GAD isoforms, GAD67 and GAD65, in the mouse hippocampus: a digitized quantitative analysis, J. Comp. Neurol., 395, 177, 10.1002/(SICI)1096-9861(19980601)395:2<177::AID-CNE3>3.0.CO;2-# Funato, 1998, Quantitation of amyloid β-protein (Aβ) in the cortex during aging and in Alzheimer's disease, Am. J. Pathol., 152, 1633 Geddes, 1994, Effects of intrahippocampal colchicine administration on the levels and localization of microtubule-associated proteins, tau and MAP2, Brain Res., 633, 1, 10.1016/0006-8993(94)91515-6 Hama, 2001, Clearance of extracellular and cell-associated amyloid β peptide through viral expression of neprilysin in primary neurons, J. Biochem. (Tokyo), 130, 721, 10.1093/oxfordjournals.jbchem.a003040 Hardy, 1997, Amyloid, the presenilins and Alzheimer's disease, Trends Neurosci., 20, 154, 10.1016/S0166-2236(96)01030-2 Holtzman, 2000, Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease, Proc. Natl. Acad. Sci. USA, 97, 2892, 10.1073/pnas.050004797 Huber, 1984, Differences in the cellular distributions of two microtubule-associated proteins, MAP1 and MAP2, in rat brain, J. Neurosci., 4, 151, 10.1523/JNEUROSCI.04-01-00151.1984 Ichikawa, 1997, Localization of two cholinergic markers, choline acetyltransferase and vesicular acetylcholine transporter in the central nervous system of the rat: in situ hybridization histochemistry and immunohistochemistry, J. Chem. Neuroanat., 13, 23, 10.1016/S0891-0618(97)00021-5 Irizarry, 2000, Apolipoprotein E affects the amount, form, and anatomical distribution of amyloid β-peptide deposition in homozygous APP(V717F) transgenic mice, Acta Neuropathol. (Berlin), 100, 451, 10.1007/s004010000263 Iwata, 2000, Identification of the major Aβ1–42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition, Nat. Med., 6, 143, 10.1038/72237 Iwata, 2001, Metabolic regulation of brain Aβ by neprilysin, Science, 292, 1550, 10.1126/science.1059946 Kanemaru, 1998, Comparable amyloid β-protein (Aβ) 42(43) and Aβ40 deposition in the aged monkey brain, Neurosci. Lett., 214, 196, 10.1016/0304-3940(96)12893-7 Li, 1995, Tissue-specific expression of rat neutral endopeptidase (neprilysin) mRNAs, J. Biol. Chem., 270, 5723, 10.1074/jbc.270.11.5723 Lu, 1995, Neutral endopeptidase modulation of septic shock, J. Exp. Med., 181, 2271, 10.1084/jem.181.6.2271 Marczynski, 1998, GABAergic deafferentation hypothesis of brain aging and Alzheimer's disease revisited, Brain Res. Bull., 45, 341, 10.1016/S0361-9230(97)00347-X Mucke, 2000, High-level neuronal expression of Aβ1–42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation, J. Neurosci., 20, 4050, 10.1523/JNEUROSCI.20-11-04050.2000 Nagatsu, 1998, Catecholamine synthesis and release., Overview Adv. Pharmacol., 42, 1 Nakano, 1999, Accumulation of murine amyloidβ42 in a gene-dosage-dependent manner in PS1 ‘knock-in’ mice, Eur. J. Neurosci., 11, 2577, 10.1046/j.1460-9568.1999.00698.x Obata, 1999, Synaptic localization of the 67 000 mol. wt isoform of glutamate decarboxylase and transmitter function of GABA in the mouse cerebellum lacking the 65 000 mol. wt isoform, Neuroscience, 93, 1475, 10.1016/S0306-4522(99)00274-2 O'Cuinn, 1995, 99 Pakaski, 1998, Vulnerability of small GABAergic neurons to human β-amyloid pentapeptide, Brain Res., 796, 239, 10.1016/S0006-8993(98)00358-8 Phinney, 1999, Cerebral amyloid induces aberrant axonal sprouting and ectopic terminal formation in amyloid precursor protein transgenic mice, J. Neurosci., 19, 8552, 10.1523/JNEUROSCI.19-19-08552.1999 Pollard, 1989, Detailed immunoautoradiographic mapping of enkephalinase (EC 3.4.24.11) in rat central nervous system: comparison with enkephalins and substance P, Neuroscience, 30, 339, 10.1016/0306-4522(89)90258-3 Price, 2000, Alzheimer's disease: the value of transgenic and gene targeted models, Neurosci. News, 3, 71 Roques, 1993, Neutral endopeptidase 24.11: structure, inhibition, and experimental and clinical pharmacology, Pharmacol. Rev., 45, 87 Saido, 1995, Dominant and differential deposition of distinct β-amyloid peptide species, AβN3(pE), in senile plaques, Neuron, 14, 457, 10.1016/0896-6273(95)90301-1 Saido, 1998, Alzheimer's disease as proteolytic disorders: anabolism and catabolism of β-amyloid, Neurobiol. Aging, 19, S69, 10.1016/S0197-4580(98)00033-5 Saido, 2000, Degradation of amyloid-beta peptide: a key to Alzheimer pathogenesis, prevention and therapy, Neurosci. News, 3, 52 Saria, 1997, Opioid-related changes in nociceptive threshold and in tissue levels of enkephalins after target disruption of the gene for neutral endopeptidase (EC 3.4.24.11) in mice, Neurosci. Lett., 234, 27, 10.1016/S0304-3940(97)00660-5 Sato, 1991, A monoclonal antibody to common acute lymphoblastic leukemia antigen (neutral endopeptidase) immunostains senile plaques in the brains of patients with Alzheimer's disease, Neurosci. Lett., 121, 271, 10.1016/0304-3940(91)90702-U Satou, 1997, The progression of β-amyloid deposition in the frontal cortex of the aged canine, Brain Res., 774, 35, 10.1016/S0006-8993(97)81684-8 Schindler, 1996, Somatostatin receptors in the central nervous system, Prog. Neurobiol., 50, 9, 10.1016/0301-0082(96)00030-5 Selkoe, 2001, Alzheimer's disease: genes, proteins, and therapy, Physiol. Rev., 81, 741, 10.1152/physrev.2001.81.2.741 Sherrington, 1995, Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease, Nature, 375, 754, 10.1038/375754a0 Shigemoto, 1997, Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus, J. Neurosci., 17, 7503, 10.1523/JNEUROSCI.17-19-07503.1997 Shirotani, 2001, Neprilysin degrades both amyloid β peptides 1–40 and 1–42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases, J. Biol. Chem., 276, 21895, 10.1074/jbc.M008511200 Shukla, 2001, Tau, β-amyloid and β-amyloid precursor protein distribution in the entorhinal-hippocampal alvear and perforant pathways in the Alzheimer's brain, Neurosci. Lett., 303, 193, 10.1016/S0304-3940(01)01719-0 Steward, 1976, Topographic organization of the projections from the entorhinal area to the hippocampal formation of the rat, J. Comp. Neurol., 167, 285, 10.1002/cne.901670303 Strittmatter, 1995, Apolipoprotein E and Alzheimer disease, Proc. Natl. Acad. Sci. USA, 92, 4725, 10.1073/pnas.92.11.4725 Sturchler-Pierrat, 1997, Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology, Proc. Natl. Acad. Sci. USA, 94, 13287, 10.1073/pnas.94.24.13287 Sturiale, 1999, Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P, Proc. Natl. Acad. Sci. USA, 96, 11653, 10.1073/pnas.96.20.11653 Su, 1998, Selective deposition of amyloid-β protein in the entorhinal-dentate projection of a transgenic mouse model of Alzheimer's disease, J. Neurosci. Res., 53, 177, 10.1002/(SICI)1097-4547(19980715)53:2<177::AID-JNR6>3.0.CO;2-4 Takaki, 2000, Biochemical identification of the neutral endopeptidase family member responsible for the catabolism of amyloid β peptide in the brain, J. Biochem. (Tokyo), 128, 897, 10.1093/oxfordjournals.jbchem.a022839 Tashiro, 1997, Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortex, Neuroreport, 8, 2797, 10.1097/00001756-199708180-00029 Terry, 1991, Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment, Ann. Neurol., 30, 572, 10.1002/ana.410300410 Testa, 1998, Immunohistochemical localization of metabotropic glutamate receptors mGluR1a and mGluR2/3 in the rat basal ganglia, J. Comp. Neurol., 390, 5, 10.1002/(SICI)1096-9861(19980105)390:1<5::AID-CNE2>3.0.CO;2-6 Tomidokoro, 2000, Impaired neurotransmitter systems by Aβ amyloidosis in APPsw transgenic mice overexpressing amyloid β protein precursor, Neurosci. Lett., 292, 155, 10.1016/S0304-3940(00)01443-9 Vekrellis, 2000, Neurons regulate extracellular levels of amyloid β-protein via proteolysis by insulin-degrading enzyme, J. Neurosci., 20, 1657, 10.1523/JNEUROSCI.20-05-01657.2000 Waksman, 1986, Neuronal localization of the neutral endopeptidase 'enkephalinase' in rat brain revealed by lesions and autoradiography, EMBO J., 5, 3163, 10.1002/j.1460-2075.1986.tb04624.x Waksman, 1986, Autoradiographic comparison of the distribution of the neutral endopeptidase ‘enkephalinase’ and of mu and delta opioid receptors in rat brain, Proc. Natl. Acad. Sci. USA, 83, 1523, 10.1073/pnas.83.5.1523 Watanabe, 1998, Selective scarcity of NMDA receptor channel subunits in the stratum lucidum (mossy fibre-recipient layer) of the mouse hippocampal CA3 subfield, Eur. J. Neurosci., 10, 478, 10.1046/j.1460-9568.1998.00063.x Wiedenmann, 1985, Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38 000 characteristic of presynaptic vesicles, Cell, 41, 1017, 10.1016/S0092-8674(85)80082-9 Yasojima, 2001, Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of β-amyloid peptide, Neurosci. Lett., 297, 97, 10.1016/S0304-3940(00)01675-X