Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells

Cell Chemical Biology - Tập 24 - Trang 371-380 - 2017
Anthony Tumber1,2, Andrea Nuzzi1,2, Edward S. Hookway3, Stephanie B. Hatch1,2, Srikannathasan Velupillai1,2, Catrine Johansson3,4, Akane Kawamura4,5, Pavel Savitsky1, Clarence Yapp1,2, Aleksandra Szykowska1, Na Wu3, Chas Bountra1, Claire Strain-Damerell1, Nicola A. Burgess-Brown1, Gian Filippo Ruda1,2, Oleg Fedorov1,2, Shonagh Munro6, Katherine S. England1,2, Radoslaw P. Nowak1,3, Christopher J. Schofield4
1Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK
2Nuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford OX3 7FZ, UK
3NIHR Oxford Biomedical Research Unit, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford OX3 7LD, UK
4Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK
5Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7BN, UK
6Department of Oncology, University of Oxford, Oxford, OX3 7DQ, UK

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