Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells
Tài liệu tham khảo
Akimoto, 2008, Spermatogenesis-specific association of SMCY and MSH5, Genes to Cells, 13, 623, 10.1111/j.1365-2443.2008.01193.x
Bankevich, 2012, SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing, J. Comput. Biol., 19, 455, 10.1089/cmb.2012.0021
Barrett, 2002, PLU-1 nuclear protein, which is upregulated in breast cancer, shows restricted expression in normal human adult tissues: a new cancer/testis antigen?, Int. J. Cancer, 101, 581, 10.1002/ijc.10644
Bavetsias, 2016, 8-Substituted pyrido[3,4-d]pyrimidin-4(3H)-one derivatives as potent, cell permeable, KDM4 (JMJD2) and KDM5 (JARID1) histone lysine demethylase inhibitors, J. Med. Chem., 59, 1388, 10.1021/acs.jmedchem.5b01635
Cellot, 2013, RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity, Blood, 122, 1545, 10.1182/blood-2013-04-496281
Chai, 2013, Regulation of the boundaries of accessible chromatin, PLoS Genet., 9, e1003778, 10.1371/journal.pgen.1003778
Dey, 2008, The histone demethylase KDM5b/JARID1b plays a role in cell fate decisions by blocking terminal differentiation, Mol. Cell Biol., 28, 5312, 10.1128/MCB.00128-08
ENCODE Project Consortium, 2012, An integrated encyclopedia of DNA elements in the human genome, Nature, 489, 57, 10.1038/nature11247
England, 2014, Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor, MedChemComm, 5, 1879, 10.1039/C4MD00291A
Gehling, 2016, Identification of potent, selective KDM5 inhibitors, Bioorg. Med. Chem. Lett., 26, 4350, 10.1016/j.bmcl.2016.07.026
Hopkinson, 2013, 5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation, Chem. Sci., 4, 3110, 10.1039/c3sc51122g
Horton, 2016, Structural basis for KDM5A histone lysine demethylase inhibition by diverse compounds, Cell Chem. Biol., 23, 769, 10.1016/j.chembiol.2016.06.006
Itoh, 2015, Identification of Jumonji AT-rich interactive domain 1A inhibitors and their effect on cancer cells, ACS Med. Chem. Lett., 6, 665, 10.1021/acsmedchemlett.5b00083
Johansson, 2014, The roles of Jumonji-type oxygenases in human disease, Epigenomics, 6, 89, 10.2217/epi.13.79
Johansson, 2016, Structural analysis of human KDM5B guides histone demethylase inhibitor development, Nat. Chem. Biol., 12, 539, 10.1038/nchembio.2087
Kooistra, 2012, Molecular mechanisms and potential functions of histone demethylases, Nat. Rev. Mol. Cell Biol., 13, 297, 10.1038/nrm3327
Kruidenier, 2012, A selective Jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response, Nature, 488, 404, 10.1038/nature11262
Labelle, 2014
Lambert, 2014, Incorporating DNA shearing in standard affinity purification allows simultaneous identification of both soluble and chromatin-bound interaction partners, J. Proteomics, 100, 55, 10.1016/j.jprot.2013.12.022
Lauberth, 2013, H3K4me3 interactions with TAF3 regulate preinitiation complex assembly and selective gene activation, Cell, 152, 1021, 10.1016/j.cell.2013.01.052
Li, 2014, Critical role of histone demethylase RBP2 in human gastric cancer angiogenesis, Mol. Cancer, 13, 1, 10.1186/1476-4598-13-81
Liang, 2013, Histone demethylase retinoblastoma binding protein 2 is overexpressed in hepatocellular carcinoma and negatively regulated by hsa-miR-212, PLoS One, 8, e69784, 10.1371/journal.pone.0069784
Liang, 2016, Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies, Bioorg. Med. Chem. Lett., 26, 4036, 10.1016/j.bmcl.2016.06.078
Madsen, 2003, PLU-1, a transcriptional repressor and putative testis-cancer antigen, has a specific expression and localisation pattern during meiosis, Chromosoma, 112, 124, 10.1007/s00412-003-0252-6
McAllister, 2016, Recent progress in histone demethylase inhibitors, J. Med. Chem., 59, 1308, 10.1021/acs.jmedchem.5b01758
Ng, 2009, Dynamic protein methylation in chromatin biology, Cell Mol. Life Sci., 66, 407, 10.1007/s00018-008-8303-z
Orlando, 2014, Quantitative ChIP-seq normalization reveals global modulation of the epigenome, Cell Rep., 9, 1163, 10.1016/j.celrep.2014.10.018
Pasini, 2008, Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2, Genes Dev., 22, 1345, 10.1101/gad.470008
Roesch, 2010, A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth, Cell, 141, 583, 10.1016/j.cell.2010.04.020
Santos-Reboucas, 2011, A novel nonsense mutation in KDM5C/JARID1C gene causing intellectual disability, short stature and speech delay, Neurosci. Lett., 498, 67, 10.1016/j.neulet.2011.04.065
Schiller, 2014, A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1, ChemMedChem, 9, 566, 10.1002/cmdc.201300428
Schulz, 2014, Fiona: a parallel and automatic strategy for read error correction, Bioinformatics (Oxford, England), 30, i356, 10.1093/bioinformatics/btu440
Tanny, 2014, Chromatin modification by the RNA polymerase II elongation complex, Transcription, 5, e988093, 10.4161/21541264.2014.988093
Teng, 2013, Histone demethylase RBP2 promotes lung tumorigenesis and cancer metastasis, Cancer Res., 73, 4711, 10.1158/0008-5472.CAN-12-3165
Thirstrup, 2011, Endogenous 2-oxoglutarate levels impact potencies of competitive HIF prolyl hydroxylase inhibitors, Pharmacol. Res., 64, 268, 10.1016/j.phrs.2011.03.017
Vinogradova, 2016, An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells, Nat. Chem. Biol., 12, 531, 10.1038/nchembio.2085
Wang, 2009, Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger, Nature, 459, 847, 10.1038/nature08036
Wang, 2013, A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth, Nat. Commun., 4, 2035, 10.1038/ncomms3035
Wang, 2015, Overexpression of JARID1B is associated with poor prognosis and chemotherapy resistance in epithelial ovarian cancer, Tumour Biol., 36, 2465, 10.1007/s13277-014-2859-z
Westaway, 2016, Cell penetrant inhibitors of the KDM4 and KDM5 families of histone lysine demethylases. 1. 3-Amino-4-pyridine carboxylate derivatives, J. Med. Chem., 59, 1357, 10.1021/acs.jmedchem.5b01537
Westaway, 2016, Cell penetrant inhibitors of the KDM4 and KDM5 families of histone lysine demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one derivatives, J. Med. Chem., 59, 1370, 10.1021/acs.jmedchem.5b01538
Wu, 2016, Discovery of KDM5A inhibitors: homology modeling, virtual screening and structure–activity relationship analysis, Bioorg. Med. Chem. Lett., 26, 2284, 10.1016/j.bmcl.2016.03.048
Zeng, 2010, The histone demethylase RBP2 Is overexpressed in gastric cancer and its inhibition triggers senescence of cancer cells, Gastroenterology, 138, 981, 10.1053/j.gastro.2009.10.004