Thymoquinone treatment against acetaminophen-induced hepatotoxicity in rats

Bonkovsky, 1994, Acute hepatic and renal toxicity from low doses of acetaminophen in the absence of alcohol abuse or malnutrition: evidence for increased susceptibility to drug toxicity due to cardiopulmonary and renal insufficiency, Hepatology, 19, 1141, 10.1002/hep.1840190511 Bromer, 2003, Acetaminophen hepatotoxicity, Clin Liver Dis, 7, 351, 10.1016/S1089-3261(03)00025-4 Gibson, 1996, Mechanism of acetaminophen-induced hepatotoxicity: covalent binding versus oxidative stress, Chem Res Toxicol, 9, 580, 10.1021/tx950153d Vaquero, 2007, Mild hypothermia attenuates liver injury and improves survival in mice with acetaminophen toxicity, Gastroenterology, 132, 372, 10.1053/j.gastro.2006.11.025 Nagi, 2000, Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity in rats: a possible mechanism of protection, Pharmacol Res, 41, 283, 10.1006/phrs.1999.0585 Nagi, 2010, Thymoquinone supplementation reverses acetaminophen-induced oxidative stress, nitric oxide production and energy decline in mice liver, Food Chem Toxicol, 48, 2361, 10.1016/j.fct.2010.05.072 Kapan, 2012, Thymoquinone ameliorates bacterial translocation and inflammatory response in rats with intestinal obstruction, Int J Surg, 10, 484, 10.1016/j.ijsu.2012.06.006 Kanter, 2005, Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats, World J Gastroenterol, 11, 6684, 10.3748/wjg.v11.i42.6684 Badary, 1997, Thymoquinone ameliorates the nephrotoxicity induced by cisplatin in rodents and potentiates its antitumor activity, Can J Physiol Pharmacol, 75, 1356, 10.1139/y97-169 Kanter, 2006, The antioxidative and antihistaminic effect of Nigella sativa and its major constituent, thymoquinone on ethanol-induced gastric mucosal damage, Arch Toxicol, 80, 217, 10.1007/s00204-005-0037-1 Nili-Ahmadabadi, 2011, Protective effect of pretreatment with thymoquinone against Aflatoxin B(1) induced liver toxicity in mice, Daru, 19, 282 Chehl, 2009, Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells, HPB Oxf, 11, 373, 10.1111/j.1477-2574.2009.00059.x Peng, 2013, Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-kappaB pathway, Oncol Rep, 29, 571, 10.3892/or.2012.2165 Kouidhi, 2011, Antibacterial and resistance-modifying activities of thymoquinone against oral pathogens, Ann Clin Microbiol Antimicrob, 10, 29, 10.1186/1476-0711-10-29 Salem, 2005, Immunomodulatory and therapeutic properties of the Nigella sativa L. seed, Int Immunopharmacol, 5, 1749, 10.1016/j.intimp.2005.06.008 Mansour, 2002, Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: a possible mechanism of action, Cell Biochem Funct, 20, 143, 10.1002/cbf.968 Esterbauer, 1990, Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal, Methods Enzymol, 186, 407, 10.1016/0076-6879(90)86134-H Fridovich, 1974, Superoxide dismutases, Adv Enzymol Relat Areas Mol Biol, 41, 35 Camargo, 1997, Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent, Hepatology, 26, 1513, 10.1002/hep.510260619 Tufek, 2013, The protective effects of dexmedetomidine on the liver and remote organs against hepatic ischemia reperfusion injury in rats, Int J Surg, 11, 96, 10.1016/j.ijsu.2012.12.003 Yapar, 2007, Hepatoprotective effect of L-carnitine against acute acetaminophen toxicity in mice, Exp Toxicol Pathol, 59, 121, 10.1016/j.etp.2007.02.009 Bessems, 2001, Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches, Crit Rev Toxicol, 31, 55, 10.1080/20014091111677 Chandrasekaran, 2011, Anti-hepatotoxic effects of 3,4-methylenedioxyphenol and N-acetylcysteine in acutely acetaminophen-overdosed mice, Hum Exp Toxicol, 30, 1609, 10.1177/0960327110394226 Whyte, 2007, Safety and efficacy of intravenous N-acetylcysteine for acetaminophen overdose: analysis of the Hunter Area Toxicology Service (HATS) database, Curr Med Res Opin, 23, 2359, 10.1185/030079907X219715 Ali, 2003, Pharmacological and toxicological properties of Nigella sativa, Phytother Res, 17, 299, 10.1002/ptr.1309 Houghton, 1995, Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation, Planta Med, 61, 33, 10.1055/s-2006-957994 Bayrak, 2008, Nigella sativa protects against ischaemia/reperfusion injury in rat kidneys, Nephrol Dial Transplant Off Publ Eur Dial Transplant Assoc – Eur Ren Assoc, 23, 2206 Meotti, 2006, Protective effect of crude extract from Wedelia paludosa (Asteraceae) on the hepatotoxicity induced by paracetamol in mice, J Pharm Pharmacol, 58, 137, 10.1211/jpp.58.1.0017 Tayman, 2013, Protective effects of Nigella sativa oil in hyperoxia-induced lung injury, Arch Bronconeumologia, 49, 15 Ebru, 2008, Cardioprotective effects of Nigella sativa oil on cyclosporine A-induced cardiotoxicity in rats, Basic Clin Pharmacol Toxicol, 103, 574, 10.1111/j.1742-7843.2008.00313.x Burits, 2000, Antioxidant activity of Nigella sativa essential oil, Phytother Res, 14, 323, 10.1002/1099-1573(200008)14:5<323::AID-PTR621>3.0.CO;2-Q Liu, 2012, Protective effects of 5-methoxypsoralen against acetaminophen-induced hepatotoxicity in mice, World J Gastroenterol, 18, 2197, 10.3748/wjg.v18.i18.2197 Sahin, 2013, The protective effects of caffeic acid phenethyl ester in isoniazid and ethambutol-induced ocular toxicity of rats, Cutan Ocul Toxicol Michael Brown, 2012, Novel protective mechanisms for S-adenosyl-L-methionine against acetaminophen hepatotoxicity: improvement of key antioxidant enzymatic function, Toxicol Lett, 212, 320, 10.1016/j.toxlet.2012.05.018 Wang, 2010, Gentiana manshurica Kitagawa prevents acetaminophen-induced acute hepatic injury in mice via inhibiting JNK/ERK MAPK pathway, World J Gastroenterol, 16, 384, 10.3748/wjg.v16.i3.384 Mirochnitchenko, 1999, Acetaminophen toxicity. Opposite effects of two forms of glutathione peroxidase, J Biol Chem, 274, 10349, 10.1074/jbc.274.15.10349