Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
Tóm tắt
Từ khóa
Tài liệu tham khảo
Ahern, 2010, Interleukin-23 drives intestinal inflammation through direct activity on T cells, Immunity, 33, 279, 10.1016/j.immuni.2010.08.010
Arany, 1996, An essential role for p300/CBP in the cellular response to hypoxia, Proc. Natl. Acad. Sci. USA, 93, 12969, 10.1073/pnas.93.23.12969
Barnes, 2009, Regulatory T cells reinforce intestinal homeostasis, Immunity, 31, 401, 10.1016/j.immuni.2009.08.011
Bauquet, 2009, The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells, Nat. Immunol., 10, 167, 10.1038/ni.1690
Bettelli, 2006, Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells, Nature, 441, 235, 10.1038/nature04753
Chen, 2003, Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3, J. Exp. Med., 198, 1875, 10.1084/jem.20030152
Davidson, 2007, Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells, J. Immunol., 178, 4022, 10.4049/jimmunol.178.7.4022
Delgoffe, 2009, mTOR: taking cues from the immune microenvironment, Immunology, 127, 459, 10.1111/j.1365-2567.2009.03125.x
Delgoffe, 2009, The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment, Immunity, 30, 832, 10.1016/j.immuni.2009.04.014
Delgoffe, 2011, The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2, Nat. Immunol., 12, 295, 10.1038/ni.2005
Dong, 2008, TH17 cells in development: an updated view of their molecular identity and genetic programming, Nat. Rev. Immunol., 8, 337, 10.1038/nri2295
Durant, 2010, Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis, Immunity, 32, 605, 10.1016/j.immuni.2010.05.003
Fife, 2009, Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal, Nat. Immunol., 10, 1185, 10.1038/ni.1790
Fontenot, 2005, Regulatory T cell lineage specification by the forkhead transcription factor foxp3, Immunity, 22, 329, 10.1016/j.immuni.2005.01.016
Getnet, 2010, A role for the transcription factor Helios in human CD4(+)CD25(+) regulatory T cells, Mol. Immunol., 47, 1595, 10.1016/j.molimm.2010.02.001
Harris, 2007, Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity, J. Immunol., 179, 4313, 10.4049/jimmunol.179.7.4313
Hot, 2011, Effects of interleukin (IL)-17A and IL-17F in human rheumatoid arthritis synoviocytes, Ann. Rheum. Dis., 70, 727, 10.1136/ard.2010.143768
Ivanov, 2006, The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells, Cell, 126, 1121, 10.1016/j.cell.2006.07.035
Koch, 2002, Measurement of absolute oxygen levels in cells and tissues using oxygen sensors and 2-nitroimidazole EF5, Methods Enzymol., 352, 3, 10.1016/S0076-6879(02)52003-6
Korn, 2009, IL-17 and Th17 Cells, Annu. Rev. Immunol., 27, 485, 10.1146/annurev.immunol.021908.132710
Littman, 2010, Th17 and regulatory T cells in mediating and restraining inflammation, Cell, 140, 845, 10.1016/j.cell.2010.02.021
Luger, 2008, Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category, J. Exp. Med., 205, 799, 10.1084/jem.20071258
Lukashev, 2006, Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes, J. Immunol., 177, 4962, 10.4049/jimmunol.177.8.4962
Mangan, 2006, Transforming growth factor-beta induces development of the T(H)17 lineage, Nature, 441, 231, 10.1038/nature04754
O'Quinn, 2008, Emergence of the Th17 pathway and its role in host defense, Adv. Immunol., 99, 115, 10.1016/S0065-2776(08)00605-6
Pan, 2005, Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation, EMBO J., 24, 2104, 10.1038/sj.emboj.7600685
Pan, 2009, Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells, Science, 325, 1142, 10.1126/science.1176077
Pouysségur, 2006, Redox regulation of the hypoxia-inducible factor, Biol. Chem., 387, 1337, 10.1515/BC.2006.167
Rajewsky, 2008, Lymphocyte development: overview, Curr. Opin. Immunol., 20, 127, 10.1016/j.coi.2008.04.005
Sakaguchi, 2008, Regulatory T cells and immune tolerance, Cell, 133, 775, 10.1016/j.cell.2008.05.009
Schraml, 2009, The AP-1 transcription factor Batf controls T(H)17 differentiation, Nature, 460, 405, 10.1038/nature08114
Semenza, 2007, Hypoxia-inducible factor 1 (HIF-1) pathway, Sci. STKE, 2007, cm8, 10.1126/stke.4072007cm8
Shi, 2011, HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells, J. Exp. Med., 208, 1367, 10.1084/jem.20110278
Thompson, 2004, Regulation of the p300 HAT domain via a novel activation loop, Nat. Struct. Mol. Biol., 11, 308, 10.1038/nsmb740
Veldhoen, 2006, TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells, Immunity, 24, 179, 10.1016/j.immuni.2006.01.001
Veldhoen, 2008, The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins, Nature, 453, 106, 10.1038/nature06881
Weaver, 2007, IL-17 family cytokines and the expanding diversity of effector T cell lineages, Annu. Rev. Immunol., 25, 821, 10.1146/annurev.immunol.25.022106.141557
Wu, 2009, A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses, Nat. Med., 15, 1016, 10.1038/nm.2015
Xu, 2005, Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways, Oncogene, 24, 5552, 10.1038/sj.onc.1208719
Yang, 2007, STAT3 regulates cytokine-mediated generation of inflammatory helper T cells, J. Biol. Chem., 282, 9358, 10.1074/jbc.C600321200
Yang, 2008, Molecular antagonism and plasticity of regulatory and inflammatory T cell programs, Immunity, 29, 44, 10.1016/j.immuni.2008.05.007
Yang, 2008, T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma, Immunity, 28, 29, 10.1016/j.immuni.2007.11.016
Youn, 2000, Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis, EMBO J., 19, 4323, 10.1093/emboj/19.16.4323
Zhang, 2008, Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth, Proc. Natl. Acad. Sci. USA, 105, 19579, 10.1073/pnas.0809763105
Zheng, 2010, Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate, Nature, 463, 808, 10.1038/nature08750
Zhou, 2008, TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function, Nature, 453, 236, 10.1038/nature06878
Zhu, 2010, Differentiation of effector CD4 T cell populations (∗), Annu. Rev. Immunol., 28, 445, 10.1146/annurev-immunol-030409-101212
Harris, T.J., Grosso, J.F., Yen, H.R., Xin, H., Kortylewski, M., Albesiano, E., Hipkiss, E.L., Getnet, D., Goldberg, M.V., Maris, C.H., et al. (2007). Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity. J. Immunol. 179, 4313–4317.
Korn, T., Mitsdoerffer, M., Croxford, A.L., Awasthi, A., Dardalhon, V.A., Galileos, G., Vollmar, P., Stritesky, G.L., Kaplan, M.H., Waisman, A., et al. (2008). IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells. Proc. Natl. Acad. Sci. USA 105, 18460–18465.
Pan, F., Means, A.R., and Liu, J.O. (2005). Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation. EMBO J. 24, 2104–2113.
Schraml, B.U., Hildner, K., Ise, W., Lee, W.L., Smith, W.A., Solomon, B., Sahota, G., Sim, J., Mukasa, R., Cemerski, S., et al. (2009). The AP-1 transcription factor Batf controls T(H)17 differentiation. Nature 460, 405–409.