Plasminogen activator inhibitor-2 (PAI-2) mRNA is localized in the accumbens nucleus of the mouse brain and is induced in specific brain sites after kainate excitation

Akiyama, 1993, Microglia express the type 2 plasminogen activator inhibitor in the brain of control subjects and patients with Alzheimer’s disease, Neurosci. Lett., 164, 233, 10.1016/0304-3940(93)90899-V Belin, 1989, Facultative polypeptide translocation allows a single mRNA to encode the secreted and cytosolic forms of plasminogen activators inhibitor 2, EMBO J., 8, 3287, 10.1002/j.1460-2075.1989.tb08489.x Chen, 1997, Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin, Cell, 91, 917, 10.1016/S0092-8674(00)80483-3 Costelloe, 1999, Regulation of the plasminogen activator inhibitor-2 (PAI-2) gene in murine macrophages. Demonstration of a novel pattern of responsiveness to bacterial endotoxin, J. Leukoc. Biol., 66, 172, 10.1002/jlb.66.1.172 Dickinson, 1995, Plasminogen activator inhibitor type 2 inhibits tumor necrosis factor α-induced apoptosis, J. Biol. Chem., 270, 27894, 10.1074/jbc.270.46.27894 Dougherty, 1999, The plasminogen activator inhibitor-2 gene is not required for normal murine development or survival, Proc. Natl. Acad. Sci. USA, 96, 686, 10.1073/pnas.96.2.686 Flumelli, 1999, BDNF stimulates expression, activity and release of tissue-type plasminogen activator in mouse cortical neurons, Eur. J. Neurosc., 11, 1639, 10.1046/j.1460-9568.1999.00580.x Frey, 1996, A different form of long-lasting potentiation revealed in tissue plasminogen activator mutant mice, J. Neurosci., 16, 2057, 10.1523/JNEUROSCI.16-06-02057.1996 Gan, 1995, Plasminogen activator inhibitor type 2 prevents programmed cell death of human macrophages infected with Mycobacterium avium, seroval 4′, J. Immunol., 155, 1304, 10.4049/jimmunol.155.3.1304 Hevroni, 1998, Hippocampal plasticity involves extensive gene induction and multiple cellular mechanisms, J. Mol. Neurosci., 10, 75, 10.1007/BF02737120 Honkaniemi, 1999, Prolonged expression of zinc finger immediate–early gene mRNAs and decreased protein synthesis following kainic acid induced seizures, Eur. J. Neurosci., 11, 10, 10.1046/j.1460-9568.1999.00401.x Huang, 1996, Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late-phase long-term potentiation in both Schaffer colateral and mossy fiber pathways, Proc. Natl. Acad. Sci. USA, 93, 8699, 10.1073/pnas.93.16.8699 Jensen, 1994, Cleaved intracellular plasminoen activator inhibitor 2 in human myeloleukaemia cells is a marker of apoptosis, Br. J. Cancer, 70, 834, 10.1038/bjc.1994.407 Jensen, 2000, Serpins in the human hair follicle, J. Invest. Dermatol., 114, 917, 10.1046/j.1523-1747.2000.00945.x Kawata, 1996, Expression of plasminogen activator inhibitor 2 in the adult and embryonic mouse tissues, Thromb. Haemost., 76, 569, 10.1055/s-0038-1650624 Krueger, 1997, Expression of neuroserpin, an inhibitor of tissue plasminogen activator, in the developing and adult nervous system of the mouse, J. Neurosci., 17, 8964, 10.1523/JNEUROSCI.17-23-08984.1997 Kruithof, 1995, Biological and clinical aspects of plasminogen activator inhibitor type 2, Blood, 86, 4007, 10.1182/blood.V86.11.4007.bloodjournal86114007 Kumar, 1991, Protection from tumor necrosis factor-mediated cytolysis by overexpression of plasminogen activator inhibitor type-2, J. Biol. Chem., 266, 20960, 10.1016/S0021-9258(18)54804-3 Lavker, 1998, Localization of plasminogen activator inhibitor type 2 (PAI-2) in hair and nail: implications for terminal differentiation, J. Invest. Dermatol., 110, 917, 10.1046/j.1523-1747.1998.00223.x Madani, 1999, Enhanced hippocampal long-term potentiation and learning by increased neuronal expression of tissue-type plasminogen activator in transgenic mice, EMBO J., 18, 3007, 10.1093/emboj/18.11.3007 Masos, 1996, Localization of urokinase-type plasminogen activator mRNA in the adult mouse brain, Mol. Brain Res., 35, 139, 10.1016/0169-328X(95)00199-3 Masos, 1997, mRNAs encoding urokinase-type plasminogen activator and plasminogen activator inhibitor-1 are elevated in the mouse brain following kainate-mediated excitation, Mol. Brain Res., 47, 157, 10.1016/S0169-328X(97)00040-5 Meiri, 1994, Overexpression of urokinase-type plasminogen activator in transgenic mice is correlated with impaired learning, Proc. Natl. Acad. Sci. USA, 91, 3196, 10.1073/pnas.91.8.3196 Osterwalder, 1998, The axonally secreted serine proteinase inhibitor, neuroserpin, inhibits plasminogen activators and plasmin but not thrombin, J. Biol. Chem., 273, 2312, 10.1074/jbc.273.4.2312 Qian, 1993, Tissue–plasminogen activator is induced as an immediate–early gene during seizure, kindling and long-term potentiation, Nature, 361, 453, 10.1038/361453a0 Reisine, 1996, Opioid analgesics and antagonists Ritchie, 1997, Regulation, location and activity of plasminogen activator inhibitor 2 (PAI-2) in peripheral blood monocytes, macrophages and foam cells, Thromb. Haemost., 77, 1168, 10.1055/s-0038-1656132 Risse, 1998, Differentiating cells of murine stratified squamous epithelia constitutively express plasminogen activator inhibitor type 2 (PAI-2), Histochem. Cell. Biol., 110, 559, 10.1007/s004180050318 Risse, 2000, Evidence for intracellular cleavage of plasminogen activator inhibitor type 2 (PAI-2) in normal epidermal keratinocytes, J. Cell. Physiol., 182, 281, 10.1002/(SICI)1097-4652(200002)182:2<281::AID-JCP17>3.0.CO;2-D Rivera, 1997, Tissue inhibitor of metalloproteinases-1 (TIMP-1) is differentially induced in neurons and astrocytes after seizures: Evidence for developmental, immediate early gene, and lesion response, J. Neurosci., 17, 4223, 10.1523/JNEUROSCI.17-11-04223.1997 Sappino, 1993, Extracellular proteolysis in the adult murine brain, J. Clin. Invest., 92, 679, 10.1172/JCI116637 Sheng, 1990, The regulation and function of c-fos and other immediate early genes in the nervous system, Neuron, 4, 477, 10.1016/0896-6273(90)90106-P Thewke, 1996, Expression of hepatocyte growth factor/scatter factor, its receptor, c-met, and tissue-type plasminogen activator during development of the murine olfactory system, J. Neurosci., 16, 6933, 10.1523/JNEUROSCI.16-21-06933.1996 Tsirka, 1995, Excitotoxin induced neuronal degeneration and seizure are mediated by tissue plasminogen activator, Nature, 377, 340, 10.1038/377340a0 Tsirka, 1997, An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus, J. Neurosci., 17, 543, 10.1523/JNEUROSCI.17-02-00543.1997 Vassalli, 1991, The plasminogen activator/plasmin system, J. Clin. Invest., 88, 1067, 10.1172/JCI115405 von Heijne, 1991, The efficiency of the uncleaved secretion signal in the plasminogen activator inhibitor type 2 protein can be enhanced by point mutaitons that increase its hydrophobicity, J. Biol. Chem., 266, 15240, 10.1016/S0021-9258(18)98608-4 Williams, 1999, Plasminogen activator inhibitor type 2 in human corneal epithelium, Invest. Ophthalmol. Vis. Sci., 40, 1669 Wohlwend, 1987, Plasminogen activator-specific inhibitors produced by human monocytes/macrophages, J. Exp. Med., 165, 320, 10.1084/jem.165.2.320 Wu, 2000, The tissue plasminogen activator (tPA)/plasmin extracellular proteolytic system regulates seizure-induced hippocampal mossy fiber outgrowth through a proteoglycan substrate, J. Cell Biol., 148, 1295, 10.1083/jcb.148.6.1295