PPARγ activation induces CD36 expression and stimulates foam cell like changes in rVSMCs

Prostaglandins & Other Lipid Mediators - Tập 80 - Trang 165-174 - 2006
Hyun-Joung Lim1, Seahyoung Lee2,3, Kuy-Sook Lee1, Jin-Hee Park1, Yangsoo Jang2,3, Eun Jig Lee4,5, Hyun-Young Park1
1Division of Cardiovascular Diseases, Center for Biomedical Sciences, NIH, Republic of Korea
2BK21 Project of Medical Science, Yonsei University, Republic of Korea
3Yonsei Cardiovascular Genome Center, Yonsei University College of Medicine, Republic of Korea
4Division of Endocrinology, Yonsei University College of Medicine, Republic of Korea
5Endocrinology, Northwestern University Feinberg School of Medicine, Chicago, USA

Tài liệu tham khảo

Ross, 1986, The pathogenesis of atherosclerosis—an update, N Engl J Med, 8, 488, 10.1056/NEJM198602203140806 Kruth, 2001, Macrophage foam cells and atherosclerosis, Front Biosci D, 429 Williams, 1995, The response-to-retention hypothesis of early atherogenesis, Arterioscler Thromb Vasc Biol, 5, 551, 10.1161/01.ATV.15.5.551 Tabas, 2002, Consequences of cellular cholesterol accumulation: basic concepts and physiological implications, J Clin Invest, 7, 905, 10.1172/JCI0216452 Faggiotto, 1984, Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation, Arteriosclerosis, 4, 323, 10.1161/01.ATV.4.4.323 Wolfbauer, 1986, Development of the smooth muscle foam cell: uptake of macrophage lipid inclusions, Proc Natl Acad Sci USA, 20, 7760, 10.1073/pnas.83.20.7760 Klouche, 2000, Enzymatically degraded, nonoxidized LDL induces human vascular smooth muscle cell activation, foam cell transformation, and proliferation, Circulation, 15, 1799, 10.1161/01.CIR.101.15.1799 Rong, 2003, Transdifferentiation of mouse aortic smooth muscle cells to a macrophage-like state after cholesterol loading, Proc Natl Acad Sci USA, 23, 13531, 10.1073/pnas.1735526100 Takano, 2004, Pleiotropic actions of PPAR gamma activators thiazolidinediones in cardiovascular diseases, Curr Pharm Des, 22, 2779, 10.2174/1381612043383719 Patel, 2003, Differential regulation of lipogenesis and leptin production by independent signaling pathways and rosiglitazone during human adipocyte differentiation, Diabetes, 1, 43, 10.2337/diabetes.52.1.43 Okada, 2002, Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation suppresses ischemic induction of Egr-1 and its inflammatory gene targets, FASEB J, 14, 1861, 10.1096/fj.02-0503com Bruemmer, 2003, Regulation of the growth arrest and DNA damage-inducible gene 45 (GADD45) by peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells, Circ Res, 4, e38, 10.1161/01.RES.0000088344.15288.E6 Marx, 1998, Macrophages in human atheroma contain PPARgamma: differentiation-dependent peroxisomal proliferator-activated receptor gamma (PPARgamma) expression and reduction of MMP-9 activity through PPARgamma activation in mononuclear phagocytes in vitro, Am J Pathol, 1, 17, 10.1016/S0002-9440(10)65540-X Ricote, 1998, Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein, Proc Natl Acad Sci USA, 13, 7614, 10.1073/pnas.95.13.7614 Ricote, 1998, The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation, Nature, 6662, 79, 10.1038/34178 Tontonoz, 1998, PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL, Cell, 2, 241, 10.1016/S0092-8674(00)81575-5 Yu, 2003, Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor gamma1 (PPARgamma1) overexpression, J Biol Chem, 1, 498, 10.1074/jbc.M210062200 Chawla, 2001, A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis, Mol Cell, 1, 161, 10.1016/S1097-2765(01)00164-2 Matsumoto, 2000, Arterioscler Thromb Vasc Biol, 4, 1027, 10.1161/01.ATV.20.4.1027 Bishop-Bailey, 2002, Intimal smooth muscle cells as a target for peroxisome proliferator-activated receptor-γ ligand therapy, Circ Res, 91, 210, 10.1161/01.RES.0000029080.15742.85 Inui, 1993, Transduction of mitogenic activity of platelet-derived growth factor (PDGF) AB by PDGF-beta receptor without participation of PDGF-alpha receptor in vascular smooth muscle cells, J Biol Chem, 23, 17045, 10.1016/S0021-9258(19)85299-7 Park, 2003, A dominant negative PPARgamma mutant shows altered cofactor recruitment and inhibits adipogenesis in 3T3-L1 cells, Diabetologia, 3, 365, 10.1007/s00125-003-1037-4 Lee, 2004, Simple flow cytometric method used to assess lipid accumulation in fat cells, J Lipid Res, 6, 1162, 10.1194/jlr.D300028-JLR200 Ross, 1993, The pathogenesis of atherosclerosis: a perspective for the 1990s, Nature, 6423, 801, 10.1038/362801a0 Yu, 1996, Mechanism of catecholamine-induced proliferation of vascular smooth muscle cells, Circulation, 3, 547, 10.1161/01.CIR.94.3.547 Gong, 1995, Synergistic effects of growth factors on the regulation of smooth muscle cell scavenger receptor activity, J Biol Chem, 37, 21672, 10.1074/jbc.270.37.21672 Fu, 2001, Platelet-derived growth factor promotes the expression of peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells by a phosphatidylinositol 3-kinase/Akt signaling pathway, Circ Res, 11, 1058, 10.1161/hh2301.099642 Law, 2000, Expression and function of PPARγ in rat and human vascular smooth muscle cells, Circulation, 101, 1311, 10.1161/01.CIR.101.11.1311 Owens, 1995, Regulation of differentiation of vascular smooth muscle cells, Physiol Rev, 3, 487, 10.1152/physrev.1995.75.3.487 Perry, 2003, What is the role of tropomyosin in the regulation of muscle contraction?, J Muscle Res Cell Motil, 8, 593 Desmouliere, 1992, The cytoskeleton of arterial smooth muscle cells during human and experimental atheromatosis, Kidney Int, S87 Kocher, 1986, Cytoskeletal features of normal and atheromatous human arterial smooth muscle cells, Hum Pathol, 9, 875, 10.1016/S0046-8177(86)80637-2 Chandran, 2003, Adiponectin: more than just another fat cell hormone?, Diab Care, 8, 2442, 10.2337/diacare.26.8.2442 Tontonoz, 1994, mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer, Genes Dev, 10, 1224, 10.1101/gad.8.10.1224 Maeda, 2001, PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein, Diabetes, 9, 2094, 10.2337/diabetes.50.9.2094 Pelton, 1999, PPARgamma activation induces the expression of the adipocyte fatty acid binding protein gene in human monocytes, Biochem Biophys Res Commun, 2, 456, 10.1006/bbrc.1999.1071 Yoshikawa, 2003, Mol Endocrinol, 7, 1240, 10.1210/me.2002-0190 Cabrero, 2003, Differential effects of peroxisome proliferator-activated receptor activators on the mRNA levels of genes involved in lipid metabolism in primary human monocyte-derived macrophages, Metabolism, 5, 652, 10.1053/meta.2003.50100 Ruan, 2003, PPAR agonists protect mesangial cells from interleukin 1beta-induced intracellular lipid accumulation by activating the ABCA1 cholesterol efflux pathway, J Am Soc Nephrol, 3, 593, 10.1097/01.ASN.0000050414.52908.DA Greenwalt, 1992, Membrane glycoprotein CD36: a review of its roles in adherence, signal transduction, and transfusion medicine, Blood, 5, 1105, 10.1182/blood.V80.5.1105.1105 Nozaki, 1995, Reduced uptake of oxidized low density lipoproteins in monocyte-derived macrophages from CD36-deficient subjects, J Clin Invest, 4, 1859, 10.1172/JCI118231 Davies, 2001, Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor gamma ligands and agonists, J Biol Chem, 19, 16015, 10.1074/jbc.M100878200