Neo/adjuvant chemotherapy does not improve outcome in resected primary synovial sarcoma: a study of the French Sarcoma Group

Singer, 1994, Prognostic factors predictive of survival and local recurrence for extremity soft tissue sarcoma, Ann Surg, 219, 165, 10.1097/00000658-199402000-00008 Pisters, 1996, Analysis of prognostic factors in 1,041 patients with localized soft tissue sarcomas of the extremities, J Clin Oncol, 14, 1679, 10.1200/JCO.1996.14.5.1679 Coindre, 2001, Predictive value of grade for metastasis development in the main histological types of adult soft tissue sarcomas. A study of 1240 patients from the French Federation of Cancer Centers Sarcoma Group, Cancer, 91, 1914, 10.1002/1097-0142(20010515)91:10<1914::AID-CNCR1214>3.0.CO;2-3 Singer, 1996, Synovial sarcoma: prognostic significance of tumor size, margin of resection and mitotic activity for survival, J Clin Oncol, 14, 1201, 10.1200/JCO.1996.14.4.1201 Lewis, 2000, Synovial sarcoma: a multivariate analysis of prognostic factor factors in 112 patients with primary localized tumours of the extremity, J Clin Oncol, 18, 2087, 10.1200/JCO.2000.18.10.2087 Spillane, 2000, Synovial sarcoma: a clinicopathologic, staging and prognostic assessment, J Clin Oncol, 18, 3794, 10.1200/JCO.2000.18.22.3794 Trassard, 2001, Prognostic factors in localized primary synovial sarcoma: a multicenter study of 128 patients, J Clin Oncol, 19, 525, 10.1200/JCO.2001.19.2.525 Casali, 2008, Soft tissue sarcomas: ESMO clinical recommendations for diagnosis, treatment and follow-up, Ann Oncol, 19, ii89, 10.1093/annonc/mdn101 Verweij, 1999, The reason for confining the use of adjuvant chemotherapy in soft tissue sarcoma to investigational setting, Semin Radiat Oncol, 9, 352, 10.1016/S1053-4296(99)80029-0 McCarter, 2002, Randomized clinical trials in soft tissue sarcoma, Surg Oncol Clin N Am, 11, 11, 10.1016/S1055-3207(03)00073-5 Woll, 2007, EORTC Soft Tissue & Bone Sarcoma Group. Adjuvant chemotherapy (CT) with doxorubicin and ifosfamide in resected soft tissue sarcoma (STS): interim analysis of a randomised phase III trial, J Clin Oncol, 25 Gortzak, 2001, A randomised phase II study on neo-adjuvant chemotherapy for ‘high-risk’ adult soft-tissue sarcoma, Eur J Cancer, 37, 1096, 10.1016/S0959-8049(01)00083-1 1997, Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: meta-analysis of individual data. Sarcoma Meta-analysis Collaboration, Lancet, 350, 1647, 10.1016/S0140-6736(97)08165-8 Rosen, 1994, Synovial sarcoma: uniform response of metastases to high dose ifosfamide, Cancer, 73, 2506, 10.1002/1097-0142(19940515)73:10<2506::AID-CNCR2820731009>3.0.CO;2-S Kampe, 1993, Synovial sarcoma: a study of intensive chemotherapy in 14 patients with localized disease, Cancer, 72, 2161, 10.1002/1097-0142(19931001)72:7<2161::AID-CNCR2820720716>3.0.CO;2-2 Nielsen, 2000, Effect of high-dose ifosfamide in advanced soft tissue sarcoma. A multicenter phase II study of the EORTC Soft Tissue and Bone Sarcoma Group, Eur J Cancer, 36, 61, 10.1016/S0959-8049(99)00240-3 Ferrari, 2004, Synovial sarcoma: a retrospective analysis of 271 patients of all ages treated at a single institution, Cancer, 101, 627, 10.1002/cncr.20386 Landenstein, 1993, Synovial sarcoma of childhood and adolescence: report of the German CWS-81 study, Cancer, 71, 3647, 10.1002/1097-0142(19930601)71:11<3647::AID-CNCR2820711129>3.0.CO;2-U Okcu, 2003, Synovial sarcoma of childhood and adolescence: a multicenter, multivariate analysis of outcome, J Clin Oncol, 21, 1602, 10.1200/JCO.2003.07.008 Eilber, 2007, Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma, Ann Surg, 246, 105, 10.1097/01.sla.0000262787.88639.2b Fletcher, 2002 Le Guillou, 2004, Histologic grade, but not SYT-SSX fusion type, is an important prognostic factor in patients with synovial sarcoma: a multicenter, retrospective analysis, J Clin Oncol, 22, 4040, 10.1200/JCO.2004.11.093 Hryniuk, 1988, The importance of dose intensity in the outcome of chemotherapy, 121 Gurney, 2002, How to calculate the dose of chemotherapy?, Br J Cancer, 86, 1297, 10.1038/sj.bjc.6600139 Leavey, 2007, Prognostic factors for patients with Ewing sarcoma (EWS) at first recurrence, J Clin Oncol, 25 Gelderblom, 2008, Survival after recurrent osteosarcoma: data from three European Osteosarcoma Intergroup (EOI) randomized controlled trials, J Clin Oncol, 26 van Geel, 1996, Surgical treatment of lung metastases: the European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group study of 255 patients, Cancer, 77, 675, 10.1002/(SICI)1097-0142(19960215)77:4<675::AID-CNCR13>3.0.CO;2-Y Spurrell, 2005, Prognostic factors in advanced synovial sarcoma: an analysis of 104 patients treated at the Royal Marsden Hospital, Ann Oncol, 16, 437, 10.1093/annonc/mdi082 Palmerini, 2008, Synovial sarcoma: a retrospective analysis of 250 patients treated in a single institution, J Clin Oncol, 26 Pisters, 1996, Analysis of prognostic factors in 1,041 patients with localized soft tissue sarcomas of the extremities, J Clin Oncol, 14, 1679, 10.1200/JCO.1996.14.5.1679 Ladanyi, 2005, Correlates of SYS-SSX fusion type in synovial sarcoma: getting more complex but also more interesting?, J Clin Oncol, 23, 3638, 10.1200/JCO.2005.05.379 Ladanyi, 2002, Impact of SYT-SSX fusion type on the clinical behaviour of synovial sarcoma: a multi-institutional retrospective study of 243 patients, Cancer Res, 62, 135 Frustaci, 2001, Adjuvant chemotherapy for adult soft tissue sarcomas of the extremities and girdles: results of the Italian randomized cooperative trial, J Clin Oncol, 19, 1238, 10.1200/JCO.2001.19.5.1238 Frustaci, 2003, Ifosfamide in the adjuvant therapy of soft tissue sarcomas, Oncology, 65, 80, 10.1159/000073366 Le Cesne, 2008, The end of adjuvant chemotherapy (adCT) era with doxorubicin-based regimen in resected high-grade soft tissue sarcoma (STS): pooled analysis of the two STBSG-EORTC phase III clinical trials, J Clin Oncol, 26