Neutrophil/lymphocyte ratio is associated with thromboembolic stroke in patients with non-valvular atrial fibrillation

Pieri, 2011, Stratification with CHA2DS2-VASc score is better than CHADS2 score in reducing ischemic stroke risk in patients with atrial fibrillation, Int J Stroke, 6, 466, 10.1111/j.1747-4949.2011.00650.x Mason, 2012, Impact of the CHA2DS2-VASc score on anticoagulation recommendations for atrial fibrillation, Am J Med, 125, 603, 10.1016/j.amjmed.2011.09.030 Ha, 2011, Stroke prediction using mean platelet volume in patients with atrial fibrillation, Platelets, 22, 408, 10.3109/09537104.2011.560306 Hijazi, 2012, Cardiac biomarkers are associated with an increased risk of stroke and death in patients with atrial fibrillation: a Randomized Evaluation of Long-term Anticoagulation Therapy (RE-LY) substudy, Circulation, 125, 1605, 10.1161/CIRCULATIONAHA.111.038729 Licata, 2009, Immuno-inflammatory activation in acute cardio-embolic strokes in comparison with other subtypes of ischaemic stroke, Thromb Haemost, 101, 929, 10.1160/TH08-06-0375 Rietbrock, 2008, Chronic atrial fibrillation: incidence, prevalence, and prediction of stroke using the Congestive heart failure, Hypertension, Age >75, Diabetes mellitus, and prior Stroke or transient ischemic attack (CHADS2) risk stratification scheme, Am Heart J, 156, 57, 10.1016/j.ahj.2008.03.010 Pisters, 2010, A novel user-friendly score (HAS-BLED) to assess 1year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey, Chest, 138, 1093, 10.1378/chest.10-0134 Schiller, 1989, Recommendations for quantitation of the left ventricle by two-dimensional echocardiography, J Am Soc Echocardiogr, 2, 358, 10.1016/S0894-7317(89)80014-8 Horne, 2005, Intermountain Heart Collaborative Study Group. Which white blood cell subtypes predict increased cardiovascular risk?, J Am Coll Cardiol, 45, 1638, 10.1016/j.jacc.2005.02.054 Zahorec, 2001, Ratio of neutrophil to lymphocyte counts—rapid and simple parameter of systemic inflammation and stress in critically ill, Bratisl Lek Listy, 1, 5 Onsrud, 1981, Influence of in vivo hydrocortisone on some human blood lymphocyte subpopulations. Effect on natural killer cell activity, Scand J Immunol, 13, 573, 10.1111/j.1365-3083.1981.tb00171.x Hotchkiss, 2003, The pathophysiology and treatment of sepsis, N Engl J Med, 348, 138, 10.1056/NEJMra021333 Pellizzon, 2003, Stent PAMI Investigators. Relation of admission white blood cell count to long-term outcomes after primary coronary angioplasty for acute myocardial infarction, Am J Cardiol, 91, 729, 10.1016/S0002-9149(02)03416-1 Núñez, 2008, Usefulness of the neutrophil to lymphocyte ratio in predicting long-term mortality in ST segment elevation myocardial infarction, Am J Cardiol, 101, 747, 10.1016/j.amjcard.2007.11.004 Uthamalingam, 2011, Utility of the neutrophil to lymphocyte ratio in predicting long-term outcomes in acute decompensated heart failure, Am J Cardiol, 107, 433, 10.1016/j.amjcard.2010.09.039 Aviles, 2003, Inflammation as a risk factor for atrial fibrillation, Circulation, 108, 3006, 10.1161/01.CIR.0000103131.70301.4F Aronson, 2007, Relation of C-reactive protein and new-onset atrial fibrillation in patients with acute myocardial infarction, Am J Cardiol, 100, 753, 10.1016/j.amjcard.2007.04.014 Chung, 2001, C-reactive protein elevation in patients with atrial arrhythmias. Inflammatory mechanisms and persistence of atrial fibrillation, Circulation, 104, 2886, 10.1161/hc4901.101760 Marin, 2004, Factor XIII Val34Leu polymorphism modulates the prothrombotic and inflammatory state associated with atrial fibrillation, J Mol Cell Cardiol, 37, 699, 10.1016/j.yjmcc.2004.06.001 Lip, 2007, High-sensitivity C-reactive protein and soluble CD40 ligand as indices of inflammation and platelet activation in 880 patients with nonvalvular atrial fibrillation relationship to stroke risk factors, stroke risk stratification schema, and prognosis, Stroke, 38, 1229, 10.1161/01.STR.0000260090.90508.3e Pinto, 2009, Immuno-inflammatory predictors of stroke at follow-up in patients with chronic non-valvular atrial fibrillation (NVAF), Clin Sci (Lond), 116, 781, 10.1042/CS20080372