Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells

Cell - Tập 143 - Trang 134-144 - 2010
Hugo J. Snippert1, Laurens G. van der Flier1, Toshiro Sato1, Johan H. van Es1, Maaike van den Born1, Carla Kroon-Veenboer1, Nick Barker1, Allon M. Klein2,3, Jacco van Rheenen1, Benjamin D. Simons3, Hans Clevers1
1Hubrecht Institute-KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands
2Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
3Department of Physics, Cavendish Laboratory, J.J. Thomson Avenue, Cambridge CB3 0HE, UK

Tài liệu tham khảo

Barker, 2007, Identification of stem cells in small intestine and colon by marker gene Lgr5, Nature, 449, 1003, 10.1038/nature06196 Barker, 2010, Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro, Cell Stem Cell, 6, 25, 10.1016/j.stem.2009.11.013 Ben-Naim, 1996, Coarsening and persistence in the voter model, Phys. Rev. E Stat. Phys. Plasmas Fluids Relat. Interdiscip. Topics, 53, 3078 Bramson, 1980, Asymptotics for interacting particle systems on Zd, Probab. Theory Relat. Fields, 53, 183 Cheng, 1974, Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. I. Columnar cell, Am. J. Anat., 141, 461, 10.1002/aja.1001410403 Cheng, 1974, Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types, Am. J. Anat., 141, 537, 10.1002/aja.1001410407 Clayton, 2007, A single type of progenitor cell maintains normal epidermis, Nature, 446, 185, 10.1038/nature05574 Cowan, 2004, Asymmetric cell division in C. elegans: cortical polarity and spindle positioning, Annu. Rev. Cell Dev. Biol., 20, 427, 10.1146/annurev.cellbio.19.111301.113823 Deng, 1997, Spectrosomes and fusomes anchor mitotic spindles during asymmetric germ cell divisions and facilitate the formation of a polarized microtubule array for oocyte specification in Drosophila, Dev. Biol., 189, 79, 10.1006/dbio.1997.8669 Fuller, 2007, Male and female Drosophila germline stem cells: two versions of immortality, Science, 316, 402, 10.1126/science.1140861 Griffiths, 1988, Demonstration of somatic mutation and colonic crypt clonality by X-linked enzyme histochemistry, Nature, 333, 461, 10.1038/333461a0 He, 2004, BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling, Nat. Genet., 36, 1117, 10.1038/ng1430 He, 2007, PTEN-deficient intestinal stem cells initiate intestinal polyposis, Nat. Genet., 39, 189, 10.1038/ng1928 Ireland, 2004, Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin, Gastroenterology, 126, 1236, 10.1053/j.gastro.2004.03.020 Ireland, 2005, Cellular inheritance of a Cre-activated reporter gene to determine Paneth cell longevity in the murine small intestine, Dev. Dyn., 233, 1332, 10.1002/dvdy.20446 Jaks, 2008, Lgr5 marks cycling, yet long-lived, hair follicle stem cells, Nat. Genet., 40, 1291, 10.1038/ng.239 Klein, 2010, Mouse germ line stem cells undergo stochastic turnover, Cell Stem Cell, 7, 214, 10.1016/j.stem.2010.05.017 Krapivsky, 1997, Domain statistics in coarsening systems, Phys. Rev. E Stat. Phys. Plasmas Fluids Relat. Interdiscip. Topics, 56, 3788 Li, 2010, Coexistence of quiescent and active adult stem cells in mammals, Science, 327, 542, 10.1126/science.1180794 Livet, 2007, Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system, Nature, 450, 56, 10.1038/nature06293 Lopez-Garcia, 2010, Intestinal stem cell replacement follows a neutral drift, Science, 10.1126/science.1196236 Marshman, 2002, The intestinal epithelial stem cell, Bioessays, 24, 91, 10.1002/bies.10028 Morrison, 2008, Stem cells and niches: mechanisms that promote stem cell maintenance throughout life, Cell, 132, 598, 10.1016/j.cell.2008.01.038 Neumuller, 2009, Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer, Genes Dev., 23, 2675, 10.1101/gad.1850809 Potten, 1990, Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt, Development, 110, 1001, 10.1242/dev.110.4.1001 Potten, 1974, Continuous labelling studies on mouse skin and intestine, Cell Tissue Kinet., 7, 271 Potten, 2003, Identification of a putative intestinal stem cell and early lineage marker; musashi-1, Differentiation, 71, 28, 10.1046/j.1432-0436.2003.700603.x Quyn, 2010, Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue, Cell Stem Cell, 6, 175, 10.1016/j.stem.2009.12.007 Sangiorgi, 2008, Bmi1 is expressed in vivo in intestinal stem cells, Nat. Genet., 40, 915, 10.1038/ng.165 Sato, 2009, Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche, Nature, 459, 262, 10.1038/nature07935 Snippert, 2009, Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine, Gastroenterology, 136, 2187, 10.1053/j.gastro.2009.03.002 Snippert, 2010, Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin, Science, 327, 1385, 10.1126/science.1184733 van der Flier, 2009, Stem cells, self-renewal, and differentiation in the intestinal epithelium, Annu. Rev. Physiol., 71, 241, 10.1146/annurev.physiol.010908.163145 van der Flier, 2009, Transcription factor achaete scute-like 2 controls intestinal stem cell fate, Cell, 136, 903, 10.1016/j.cell.2009.01.031 Watt, 2000, Out of Eden: stem cells and their niches, Science, 287, 1427, 10.1126/science.287.5457.1427 Winton, 1990, Stem-cell organization in mouse small intestine, Proc. Biol. Sci., 241, 13, 10.1098/rspb.1990.0059 Winton, 1988, A clonal marker induced by mutation in mouse intestinal epithelium, Nature, 333, 463, 10.1038/333463a0 Wu, 1982, The Potts model, Rev. Mod. Phys., 54, 235, 10.1103/RevModPhys.54.235 Yamashita, 2003, Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome, Science, 301, 1547, 10.1126/science.1087795 Zhu, 2009, Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation, Nature, 457, 603, 10.1038/nature07589 Bramson, M., and Griffeath, D. (1980). Asymptotics for interacting particle systems on Zd. Probab. Theory Relat. Fields 53, 183–196. Kimura, M. (1983). The Neutral Theory of Molecular Evolution (Cambridge: Cambridge University Press). Korolev, K.S., Avlund, M., Halletschek, O., and Nelson, D.R. (2010). Genetic demixing and evolution in linear stepping stone models. Rev. Mod. Phys. 82, 1691-1718. Krapivsky, P.L., and Ben-Naim, E. (1997). Domain statistics in coarsening systems. Phys. Rev. E Stat. Phys. Plasmas Fluids Relat. Interdiscip. Topics 56, 3788-3798. Liggett, T.M. (1985). Interacting Particle Systems (New York: Springer). Lopez-Garcia, C., Klein, A.M., Simons, B.D., and Winton, D.J. (2010). Intestinal stem cell replacement follows a neutral drift. Science, in press. Moran, P.A.P. (1962). The Statistical Processes of Evolutionary Theory (Oxford: Clarendon Press).