Usefulness and limitations of taste sensors in the evaluation of palatability and taste-masking in oral dosage forms

Pein, 2014, Taste-masking assessment of solid oral dosage forms – a critical review, Int J Pharm, 465, 239, 10.1016/j.ijpharm.2014.01.036 Gittings, 2014, Dissolution methodology for taste masked oral dosage forms, J Control Release, 173, 32, 10.1016/j.jconrel.2013.10.030 Slavkova, 2015, Orodispersible drug formulations for children and elderly, Eur J Pharm Sci, 75, 2, 10.1016/j.ejps.2015.02.015 Brniak, 2015, Orodispersible films and tablets with prednisolone microparticles, Eur J Pharm Sci, 75, 81, 10.1016/j.ejps.2015.04.006 Elwerfalli, 2015, New generation of orally disintegrating tablets for sustained release: a propitious outlook, Curr Drug Deliv, 12, 10.2174/1567201812666150310151238 Uchida, 2015, Trade-offs in development of various dosage form (Overview), Yakugaku Zasshi, 135, 221, 10.1248/yakushi.14-00228-1 Namiki, 2015, Clinical functionality required for orally disintegrating tablets selected as the next generation type, Yakugaku Zasshi, 135, 237, 10.1248/yakushi.14-00228-3 Seager, 1998, Drug-delivery products and the Zydis fast-dissolving dosage form, J Pharm Pharmacol, 50, 375, 10.1111/j.2042-7158.1998.tb06876.x Kobayashi, 2011, Formulation design of Vesicare OD, Pharm Tech Japan, 27, 1767 Namiki, 2013, Evaluation of Pletaal OD tablet (Hybr IDTAB) for clinical use, Pharm Tech Japan, 29, 1971 Sunada, 2014, The evolving orally disintegrating tablets – the donepezil hydrochloride orally disintegrating tablets, Pharm Tech Japan, 30, 59 Ohnishi, 2014, Development and formulation design of TS-1 combination OD tablet, Pharm Tech Japan, 30, 617 Enomoto, 2015, Evaluation of functionality of memantine hydrochloride OD tablet in patients with moderate to severe Alzheimer's disease and their caregivers, Rinsyo Iyaku, 31, 411 Bi, 1999, Rapidly disintegrating tablets prepared by the wet compression method: mechanism and optimization, J Pharm Sci, 88, 1004, 10.1021/js990061z Mizumoto, 2005, Formulation design of a novel fast-disintegrating tablet, Int J Pharm, 306, 83, 10.1016/j.ijpharm.2005.09.009 Okuda, 2009, A new formulation for orally disintegrating tablets using a suspension spray-coating method, Int J Pharm, 382, 80, 10.1016/j.ijpharm.2009.08.010 Yoshida, 2008, Optimization of salting-out taste-masking system for micro-beads containing drug with high solubility, Chem Pharm Bull, 56, 1579, 10.1248/cpb.56.1579 Yosida, 2008, Mechanism of controlled drug release form a salting-out taste-masking system, J Control Release, 131, 47, 10.1016/j.jconrel.2008.07.009 Yosida, 2009, Salting-out taste-masking system generates lag time with subsequent immediate release, Int J Pharm, 365, 81, 10.1016/j.ijpharm.2008.08.026 Niwa, 2013, Design of self-dispersible dry nanosuspension through wet milling and spray freeze-drying for poorly water-soluble drugs, Eur J Pharm Sci, 50, 272, 10.1016/j.ejps.2013.07.011 Okuda, 2014, Formulation design for orally disintegrating tablets containing enteric-coated particles, Chem Pharm Bull, 62, 407, 10.1248/cpb.c13-00752 Kluk, 2014, Application properties of oral gels as media for administration of minitablets and pellets to paediatric patients, Int J Pharm, 460, 228, 10.1016/j.ijpharm.2013.10.052 Preis, 2015, Orally disintegrating films and mini-tablets – innovative dosage forms of choice for pediatric use, AAPS PharmSciTech, 16, 234, 10.1208/s12249-015-0313-1 Terashita, 2014, Innovative pediatric formulation – micro-OD tablet technology, Pharm Tech Japan, 30, 1541 Terashita, 2015, Formulation design and evaluation of micro orally disintegrating tablet using chemical imaging by raman microspectroscopy, Pharm Tech Japan, 31, 865 Ishizaka, 2008, Suppression of bitterness and improvement of palatability of commercial predonisolone powder, Chem Pharm Bull, 56, 1395, 10.1248/cpb.56.1395 Yoshida, 2010, Bitterness suppression of the Kampo Medicine ‘Orengedokuto’ using flavoured jellies, Chem Pharm Bull, 58, 449, 10.1248/cpb.58.449 Fukui-Soubou, 2011, Efficacy, safety, and palatability of RACTAB® formulation amlodipine orally disintegrating tablets, Drugs, 11, 327 Kashiwa, 2014, Comparison of the bitterness in the orally disintegrating tablets of donepezil hydrochloride, J Jpn Soc Hosp Pharm, 50, 897 Kimura, 2015, Effect of granule properties on rough mouth feel and palatability of orally disintegrating tablets, Int J Pharm, 484, 156, 10.1016/j.ijpharm.2015.02.023 Uchida, 2001, A new method for evaluating the bitterness of medicines by semi-continuous measurement of adsorption using a taste sensor, Chem Pharm Bull, 49, 1336, 10.1248/cpb.49.1336 Miyanaga, 2002, Prediction of the bitterness of single, binary-and multiple-component amino acid solutions using a taste sensor, Int J Pharm, 248, 207, 10.1016/S0378-5173(02)00456-8 Nakamura, 2002, The effect of various substances on the suppression of the bitterness of quinine-human gustatory sensation, binding, and taste sensor studies, Chem Pharm Bull, 50, 1589, 10.1248/cpb.50.1589 Uchida, 2003, Evaluation of the bitterness of antibiotics using a taste sensor, J Pharm Pharmacol, 55, 1479, 10.1211/0022357022106 Miyanaga, 2003, Quantitative prediction of the bitterness suppression of elemental diets by various flavors using a taste sensor, Pharm Res, 20, 1932, 10.1023/B:PHAM.0000008039.59875.4f Miyanaga, 2004, Suppression of the bitterness of enteral nutrients using increased particle sizes of branched-chain amino acids (BCAAs) and various flavours: a taste sensor study, Chem Pharm Bull, 52, 490, 10.1248/cpb.52.490 Ogawa, 2004, The combination effect of L-arginine and NaCl on bitterness suppression of amino acid solutions, Chem Pharm Bull, 52, 172, 10.1248/cpb.52.172 Ishizaka, 2004, Bitterness evaluation of medicines for pediatric use by a taste sensor, Chem Pharm Bull, 52, 943, 10.1248/cpb.52.943 Kataoka, 2004, Evaluation of bottled nutritive drinks using a taste sensor, Int J Pharm, 279, 107, 10.1016/j.ijpharm.2004.04.006 Kataoka, 2005, Evaluation of the taste and smell of bottled nutritive drinks, Int J Pharm, 305, 13, 10.1016/j.ijpharm.2005.08.019 Tsuji, 2006, Evaluation of bitterness suppression of macrolide dry syrups by jellies, Chem Pharm Bull, 54, 310, 10.1248/cpb.54.310 Ishizaka, 2007, The suppression of enhanced bitterness intensity of macrolide dry syrup mixed with an acidic powder, Chem Pharm Bull, 55, 1452, 10.1248/cpb.55.1452 Tokuyama, 2006, Bitterness suppression of BCAA solutions by L-ornithine, Chem Pharm Bull, 54, 1288, 10.1248/cpb.54.1288 Hashimoto, 2007, The quantitative prediction of bitterness-suppressing effect of sweeteners on the bitterness of famotidine by sweetness-responsive sensor, Chem Pharm Bull, 55, 739, 10.1248/cpb.55.739 Harada, 2010, A new method for evaluating the bitterness of medicines in development using a taste sensor and a disintegration testing apparatus, Chem Pharm Bull, 58, 1009, 10.1248/cpb.58.1009 Ito, 2011, Bitterness evaluation of H1-receptor antagonists using a taste sensor, Sensors and Materials, 23, 483 Haraguchi, 2013, Bitterness evaluation of intact and crushed Vesicare orally disintegrating tablets using taste sensor, J Pharm Pharmacol, 65, 980, 10.1111/jphp.12078 Yoshida, 2014, Bitterness of acidic pharmaceutical substances (NSAIDs) using a taste sensor, Chem Pharm Bull, 62, 1252, 10.1248/cpb.c14-00577 Yoshida, 2015, Evaluation of the palatabilities in 10 different famotidine orally disintegrating tablets by combination of disintegration device and taste sensor, Drug Del Ind Pharm, 41, 1387, 10.3109/03639045.2014.954583 Tokuyama, 2009, Famotidine orally disintegrating tablets: bitterness comparison of original and generic products, Chem Pharm Bull, 57, 382, 10.1248/cpb.57.382 Ito, 2013, Bitterness prediction of H1-antihistamines and prediction of masking effects of artificial sweeteners using an electronic tongue, Int J Pharm, 441, 121, 10.1016/j.ijpharm.2012.11.047 Haraguchi, 2014, Evaluation of ebastine-loaded orally disintegrating tablets using new apparatus of detecting disintegration time and e-tongue system, J Drug Del Sci Tech, 24, 684, 10.1016/S1773-2247(14)50137-2 Toko, 1998, Electronic tongue, Biosens Bioelectron, 13, 701, 10.1016/S0956-5663(98)00025-6 Kobayashi, 2010, Advanced taste sensors based on artificial lipids with global selectivity to basic taste qualities and high correlation to sensory scores, Sensors, 10, 3411, 10.3390/s100403411 Uchida, 2012, Taste evaluation of medicine using taste sensor, Jpn J Taste Smell Res, 19, 133 Uchida, 2014, Recent topic of kansei biosensors on taste and odor sensing systems, Yakugaku Zassi, 134, 305, 10.1248/yakushi.13-00234-F Zheng, 2006, Taste masking analysis in pharmaceutical formulation development using an electronic tongue, Int J Pharm, 310, 118, 10.1016/j.ijpharm.2005.11.046 Maniruzzaman, 2012, Taste masking of paracetamol by hot-melt extrusion: an in vitro and in vivo evaluation, Eur J Pharm Biopharm, 80, 433, 10.1016/j.ejpb.2011.10.019 Maniruzzaman, 2014, An in-vivo and in-vitro taste masking evaluation of bitter melt-extruded drugs, J Pharm Pharmacol, 66, 323, 10.1111/jphp.12169 Maniruzzaman, 2015, An in-vitro-in-vivo taste assessment of bitter drug: comparative electronic tongues study, J Pharm Pharmacol, 67, 43, 10.1111/jphp.12319 Wei, 2015, Masking the bitter taste of injectable lidocaine HCl formulation for dental procedures, AAPS PharmSciTech, 16, 455, 10.1208/s12249-014-0239-z Nakamura, 2015, The prediction of the palatability of orally disintegrating tablets by an electronic gustatory system, Int J Pharm, 493, 305, 10.1016/j.ijpharm.2015.07.056 Narazaki, 2004, A new method for disintegration studies of rapid disintegrating tablet, Chem Pharm Bull, 52, 704, 10.1248/cpb.52.704 Harada, 2006, Evaluation of the disintegration properties of commercial famotidine 20 mg orally disintegrating tablets using a simple new test and human sensory test, Chem Pharm Bull, 54, 1072, 10.1248/cpb.54.1072 Harada, 2010, Effect of physical properties of orally disintegrating tablets on disintegration time as determined by a new apparatus, J Drug Del Sci Tech, 20, 377, 10.1016/S1773-2247(10)50062-5 Uchida, 2012, Factors affecting the bitterness intensities of ten commercial formulations of ambroxol, Chem Pharm Bull, 60, 949, 10.1248/cpb.c110458 Hoashi, 2013, Development of a novel and simple method to evaluate disintegration of rapidly disintegrating tablets, Chem Pharm Bull, 61, 962, 10.1248/cpb.c13-00441 Yoshita, 2013, Clinical disintegration time of orally disintegrating tablets clinically available in Japan in healthy volunteers, Biol Pharm Bull, 36, 1488, 10.1248/bpb.b13-00353 Matsui, 2015, Combination effect of physical and gustatory taste masking for propiverine hydrochloride orally disintegrating tablets on palatability, Biol Pharm Bull, 38, 17, 10.1248/bpb.b14-00467 Kakutani, 2010, Development of a new disintegration method for orally disintegrating tablets, Chem Pharm Bull, 58, 885, 10.1248/cpb.58.885 Uchida, 2013, Evaluation of palatability of 10 commercial amlodipine orally disintegrating tablets by gustatory sensation testing, OD-mate as a new apparatus and the artificial taste sensor, J Pharm Pharmacol, 65, 1312, 10.1111/jphp.12101 Hazekawa, 2013, Evaluation of disintegrating characteristics of commercial donepezil hydrochloride loaded orally disintegrating tablets using artificial saliva, Jpn J Med Pharm Sci, 69, 929 Hazekawa, 2014, Evaluation of disintegrating characteristics of nine commercial orally disintegrating tablets containing donepezil hydrochloride II, Jpn J Med Pharm Sci, 71, 437 Woertz, 2011, Taste sensing systems (electronic tongues) for pharmaceutical applications, Int J Pharm, 417, 256, 10.1016/j.ijpharm.2010.11.028