Intraoperative Molecular Positron Emission Tomography Imaging for Intraoperative Assessment of Radical Prostatectomy Specimens

Martini, 2021, Defining clinically meaningful positive surgical margins in patients undergoing radical prostatectomy for localised prostate cancer, Eur Urol Oncol, 4, 42, 10.1016/j.euo.2019.03.006 Schlomm, 2012, Neurovascular structure-adjacent frozen-section examination (NeuroSAFE) increases nerve-sparing frequency and reduces positive surgical margins in open and robot-assisted laparoscopic radical prostatectomy: experience after 11,069 consecutive patients, Eur Urol, 62, 333, 10.1016/j.eururo.2012.04.057 Petralia, 2015, Robot-assisted radical prostatectomy: Multiparametric MR imaging-directed intraoperative frozen-section analysis to reduce the rate of positive surgical margins, Radiology, 274, 434, 10.1148/radiol.14140044 EAU. EAU guidelines. Presented at the EAU Annual Congress Amsterdam; 2022. Muraglia, 2023, First live-experience session with PET/CT specimen imager: a pilot analysis in prostate cancer and neuroendocrine tumor, Biomedicines, 11, 645, 10.3390/biomedicines11020645 Darr, 2020, Intraoperative (68)Gallium-PSMA Cerenkov Luminescence Imaging for surgical margins in radical prostatectomy: a feasibility study, J Nucl Med, 61, 1500, 10.2967/jnumed.119.240424 Fragoso Costa, 2023, F18-PSMA Cerenkov luminescence and flexible autoradiography Imaging in a prostate cancer mouse model and first results of a radical prostatectomy feasibility study in men, J Nucl Med, 64, 598, 10.2967/jnumed.122.264670 Giesel, 2017, F-18 labelled PSMA-1007: biodistribution, radiation dosimetry and histopathological validation of tumor lesions in prostate cancer patients, Eur J Nucl Med Mol Imaging, 44, 678, 10.1007/s00259-016-3573-4 Moraitis, 2021, Imaging properties and quantification accuracy of Ga-68 and I-124 in a new generation preclinical PET/CT system: a phantom study, Eur J Nucl Med Mol Imaging Hofman, 2020, Prostate-specific membrane antigen PET-CT in patients with high-risk prostate cancer before curative-intent surgery or radiotherapy (proPSMA): a prospective, randomised, multicentre study, Lancet, 395, 1208, 10.1016/S0140-6736(20)30314-7 Murphy, 2019, Going nuclear: it is time to embed the nuclear medicine physician in the prostate cancer multidisciplinary team, BJU Int, 124, 551, 10.1111/bju.14814