Tenecteplase for thrombolysis in stroke patients: Systematic review with meta-analysis

Johnson, 2019, Global, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016, Lancet Neurol, 18, 439, 10.1016/S1474-4422(19)30034-1 Powers, 2019, Vol. 50, E344 Ahmed, 2019, Consensus statements and recommendations from the ESO-Karolinska Stroke Update Conference, Stockholm 11–13 November 2018, Eur Stroke J, 4, 307, 10.1177/2396987319863606 Tanswell, 2002, Pharmacokinetics and pharmacodynamics of tenecteplase in fibrinolytic therapy of acute myocardial infarction [Internet], Vol. 41, 1229 Campbell, 2018, Tenecteplase versus alteplase before thrombectomy for ischemic stroke, N Engl J Med, 378, 1573, 10.1056/NEJMoa1716405 Burgos, 2019, Evidence that tenecteplase is noninferior to alteplase for acute ischemic stroke: meta-analysis of 5 randomized trials, Stroke, 50, 2156, 10.1161/STROKEAHA.119.025080 Wardlaw, 2013, Thrombolysis (different doses, routes of administration and agents) for acute ischaemic stroke, Cochrane Database Syst Rev, 5 Moher, 2009, Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement, Ann Intern Med, 151, 264, 10.7326/0003-4819-151-4-200908180-00135 Parsons, 2009, Acute ischemic stroke: imaging-guided tenecteplase treatment in an extended time window, Neurology, 72, 915, 10.1212/01.wnl.0000344168.05315.9d Haley, 2010, Phase IIB/III trial of tenecteplase in acute ischemic stroke: results of a prematurely terminated randomized clinical trial, Stroke, 41, 707, 10.1161/STROKEAHA.109.572040 Parsons, 2012, A randomised trial of tenecteplase versus alteplase for acute ischemic stroke, N Engl J Med, 1099, 10.1056/NEJMoa1109842 Huang, 2015, Alteplase versus tenecteplase for thrombolysis after ischaemic stroke (ATTEST): a phase 2, randomised, open-label, blinded endpoint study, Lancet Neurol, 14, 368, 10.1016/S1474-4422(15)70017-7 Logallo, 2017, Tenecteplase versus alteplase for management of acute ischaemic stroke (NOR-TEST): a phase 3, randomised, open-label, blinded endpoint trial, Lancet Neurol, 16, 781, 10.1016/S1474-4422(17)30253-3 Rajappa, 2018, Safety and efficacy of tenecteplase compared to alteplase in acute ischaemic stroke, Int J Stroke Confer 11th World Stroke Congr WSC 2018 Canada, 13, 9 Seners, 2019, Recanalization before thrombectomy in tenecteplase vs. alteplase-treated drip-and-ship patients, J Stroke, 21, 105, 10.5853/jos.2018.01998 Rha, 2007, The impact of recanalization on ischemic stroke outcome: a meta-analysis, Stroke, 38, 967, 10.1161/01.STR.0000258112.14918.24 Kharitonova, 2011, Association of early National Institutes of Health Stroke Scale improvement with vessel recanalization and functional outcome after intravenous thrombolysis in ischemic stroke, Stroke, 42, 1638, 10.1161/STROKEAHA.110.606194 Coutts, 2015, Tenecteplase-tissue-type plasminogen activator evaluation for minor ischemic stroke with proven occlusion, Stroke, 46, 769, 10.1161/STROKEAHA.114.008504 Haley, 2005, A pilot dose-escalation safety study of tenecteplase in acute ischemic stroke, Stroke, 36, 607, 10.1161/01.STR.0000154872.73240.e9 Ramakrishnan, 2018, Efficacy and Safety of Intravenous Tenecteplase Bolus in Acute Ischemic Stroke: Results of Two Open-Label, Multicenter Trials., Am J Cardiovasc Drugs, 18, 387, 10.1007/s40256-018-0284-1 Campbell, 2020, Effect of intravenous tenecteplase dose on cerebral reperfusion before thrombectomy in patients with large vessel occlusion ischemic stroke: the EXTEND-IA TNK part 2 randomized clinical trial, JAMA, 323, 1257, 10.1001/jama.2020.1511 Zitek, 2020, Using tenecteplase for acute ischemic stroke: what is the hold up?, West J Emerg Med, 21, 199, 10.5811/westjem.2020.1.45279 Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis Tenecteplase versus Alteplase for Stroke Thrombolysis Evaluation (TASTE) Trial The Norwegian Tenecteplase Stroke Trial 2 (NOR-TEST 2) Tenecteplase in Wake-up Ischaemic Stroke Trial A Randomized Controlled Trial of TNK-tPA Versus Standard of Care for Minor Ischemic Stroke With Proven Occlusion Tenecteplase Versus Alteplase for Stroke Thrombolysis Evaluation Trial in the Ambulance