Gene therapy for rheumatoid arthritis

Springer Seminars in Immunopathology - Tập 20 - Trang 197-209 - 1998
Paul D. Robbins1, Christopher H. Evans1, Yuti Chernajovsky2
1University of Pittsburgh, Pittsburgh, USA
2Molecular Biology Laboratory, Kennedy Institute of Rheumatology, Hammersmith, UK

Tài liệu tham khảo

Bakker AC, Joosten LAB, Arntz OJ, Helsen MMA, Bendele AM, Loo FAJ van de, Berg WB van der (1997) Prevention of murine collagen-induced arthritis in the knee and ipsilateral paw by local expression of human IL-1Ra protein in the knee. Arthritis Rheum 40:893 Bakker NPM, Erck MGM van, Botman CAD, Jonker M, t'Hart BA (1991) Collagen-induced arthritis in an outbred group of rhesus monkeys comprising responder and non-responder animals. Arthritis Rheum 34:616 Bandara G, Mueller GM, Galea-Lauri J, Tindal MH, Georgescu HI, Suchanek MK, Hung GL, Glorioso JC, Robbins PD, Evans CH (1993) Intraarticular expression of biologically active IL-1 receptor antagonist protein by ex vivo gene transfer. Proc Natl Acad Sci USA 90:10 764 Bandara G, Robbins PD, Georgescu HI, Mueller GM, Glorioso JC, Evans CH (1992) Gene transfer to synoviocytes: prospects for gene treatment of arthritis. DNA Cell Biol 11:227 Bessis N, Boissier MC, Ferrara P, Blankenstein T, Fradelizi D, Fournier C (1996) Attenuation of collagen-induced arthritis in mice by treatment with vector cells engineered to secrete interleukin-13. Eur J Immunol 26:2399 Bohl D, Naffakh N, Heard J-M (1997) Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts. Nat Med 3:299 Chernajovsky Y (1998) Systemic gene therapy of arthritis. In: Robbins PD, Evans CH (eds) Innovative therapies for rheumatoid arthritis. Prous Science, Barcelona (in press) Chernajovsky Y, Adams G, Podhajcer O, Mueller G, Robbins P, Feldmann M (1995) Inhibition of transfer of collagen-induced arthritis into SCID mice by ex vivo infection of spleen cells with retroviruses expressing soluble human TNF receptor. Gene Ther 2:731 Chernajovsky Y, Adams G, Triantaphyllopoulos K, Ledda MF, Podhajcer OL (1997) Pathogenic lymphoid cells engineered to express TGF beta 1 ameliorate disease in a collagen-induced arthritis model. Gene Ther 4:553 Chernajovsky Y, Annenkov A, Herman C, Triantaphyllopoulos K, Gould D, Dreja H, Croxford JL, Mageed RA, Podhajcer OL, Baker D (1998) Gene therapy for rheumatoid arthritis: theoretical considerations. Drugs Aging 12:29 Evans C, Robbins PD (1994) Prospects for treating arthritis by gene-therapy. J Rheumatol 21:779 Evans CH, Robbins PD, Ghivizzani SC (1996) Clinical trial to assess safety, feasibility, and efficacy of transferring a potentially anti-arthritic cytokine gene to human joints with rheumatoid arthritis. Hum Gene Ther 7:1261 Feldmann M, Brennan FM, Maini RN (1996) Role of cytokines in rheumatoid arthritis. Annu Rev Immunol 14:397 Feldmann M, Elliott MJ, Woody JN, Maini RN (1997) Anti-TNFα therapy of rheumatoid arthritis. Adv Immunol 64:283 Ghivizzani SC, Lechman ER, Kang R, Tio C, Kolls J, Evans CH, Robbins PD (1998) Direct adenovirus-mediated gene transfer of IL-1 and TNF-α soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects. Proc Natl Acad Sci USA 95:4613 Ghivizzani SC, Lechman ER, Tio C, Mule KM, Chada S, McCormack JE, Evans CH, Robbins PD (1997) Direct retrovirus-mediated gene transfer to the synovium of the rabbit knee: implications for arthritis gene therapy. Gene Ther 4:977 Glorioso JC, Deluca NA, Fink DJ (1995) Development and application of herpes-simplex virus vectors for human gene-therapy. Annu Rev Microbiol 49:675 Glorioso JC, Krisky D, Marconi P, Oligino T, Ghivizzani SC, Robbins PD, Schmidt MC, Goins WF, Evans C (1997) Progress in development of herpes simplex virus gene vectors for treatment of rheumatoid arthritis. Adv Drug Delivery Rev 27:41 Holmdahl R, Jansson L, Larsson E, Rubin K, Klareskog L (1986) Homologous type II collagen induces chronic and progressive arthritis in mice. Arthritis Rheum 29:106 Jorgensen C, Apparailly F, Canovas F, Jacquet C, Verwaerde C, Sany J (1997) Chondroprotective effect of gene transfer of IL10 in type II collagen induced arthritis. Arthritis Rheum 40:1140 Joosten LAB, Liberts E, Durez P, Helsen MMA, Jacobs MJM, Goldman M, Berg WB van der (1997) Role of IL-4 and IL-10 in murine collagen-induced arthritis. Arthritis Rheum 40:249 Kang R, Marui T, Ghivizzani SC, Nita IM, Georgescu HI, Suh JK, Robbins PD, Evans CH (1997) Ex vivo gene transfer to chondrocytes in full-thickness articular cartilage defects: a feasibility study. Osteoarthritis Cartilage 5:139 Keffer J, Probert L, Cazlaris H, Georgopoulos S, Kaslaris E, Kioussis D, Kollias G (1991) Transgenic mice expressing human TNF: a predictive genetic model of arthritis. EMBO 110:4025 Kim VN, Mitrophanous K, Kingsman SM, Kingsman AJ (1998) Minimal requirement for a lentivirus vector based on human immunodeficiency virus type 1. J Virol 72:811 Kochanek S, Clemens PR, Mitani K, Chen HH, Chan S, Caskey CT (1996) A new adenoviral vector-replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase. Proc Natl Acad Sci USA 93:5731 Maini RN, Feldmann M (1993) Immunopathogenesis of rheumatoid arthritis. In: Maddison PS (ed) Oxford Textbook of Rheumatology. Oxford Medical Publications, Oxford, pp 621–638 Makarov SS, Baldwin AS (1996) Local suppression of NFkB inhibits experimental arthritis in rats. Arthritis Rheum 39:563 Makarov SS, Olsen JC, Johnston WN, Anderle SK, Brown RR, Baldwin AS, Haskill IS, Schwab JH (1996) Suppression of experimental arthritis by gene-transfer of interleukin-1 receptor antagonist cDNA. Proc Natl Acad Sci USA 93:402 Mauri C, Chu C-Q, Woodrow D, Mori L, Londei M (1997) Treatment of a newly established transgenic model of chronic arthritis with non-depleting anti-CD4 monoclonal antibody. J Immunol 159:5032 Miyata M, Sato Y, Sato H, Saito A, Irisawa A, Nishimaki T, Kasukawa R (1997) Suppression of murine collagen-induced arthritis (CIA) by inoculation of plasmid DNA encoding for interleukin (IL)-10. Arthritis Rheum 40:146 Muller-Ladner U, Franklin BN, Roberts CR, Robbins PD, Gay RE, Evans CH, Gay S (1996) Gene-transfer of interleukin-10 into human synovial fibroblasts and implantation into the scid mouse. Arthritis Rheum 39:797 Muller-Ladner U, Roberts CR, Franklin BN, Gay RE, Robbins PD, Evans CH, Gay S (1997) Human IL-1Ra gene transfer into human synovial fibroblasts is chondroprotective. J Immunol 158:3492 Muzyczka N (1992) Use of adeno-associated virus as a general transduction vector for mammalian cells. Curr Top Microbiol Immunol 158:97 Naldini L, Blömer U, Gallay P, Ory D, Mulligan R, Gage FH, Verma IM, Trono D (1996) In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272:263 Nita I, Ghivizzani SC, Galealauri J, Bandara G, Georgescu HI, Robbins PD, Evans CH (1996) Direct gene delivery to synovium — an evaluation of potential vectors in vitro and in vivo. Arthritis Rheum 39: 820 Oligino T, Poliani PL, Marconi P, Bender MA, Schmidt MC, Fink DJ, Glorioso JC (1996) In vivo transgene activation from an HSV-based gene-therapy vector by gal4-vp16. Gene Ther 3:892 Otani K, Nita I, Macaulay W, Georgescu HI, Robbins PD, Evans CH (1996) Suppression of antigen-induced arthritis in rabbits by ex vivo gene-therapy. J Immunol 156:3558 Robbins PD, Tahara H, Ghivizzani SC (1998) Viral vectors for gene therapy. Trends Biotechnol 16:35 Robbins PD, Tahara H, Mueller G, Hung G, Bahnson A, Zitvogel L, Galealauri J, Ohashi T, Patrene K, Boggs SS, Evans CH, Barranger JA, Lotze MT (1994) Retroviral vectors for use in human gene-therapy for cancer gaucher disease, and arthritis. Ann NY Acad Sci 716:72 Roessler BJ, Allen ED, Wilson JM, Hartman JW, Davidson BL (1993) Adenoviral-mediated gene transfer to rabbit synovium in vivo. J Clin Invest 92:1085 Seki N, Sudo Y, Yoshioka T, Sugihara S, Fujitsu T, Sakuma S, Ogawa T, Hamaoka T, Senoh H, Fujiwara H (1988) Type II-induced murine arthritis. I. Induction and preparation of arthritis require synergy between Immoral and cell mediated immunity. J Immunol 140:1477 Song XY, Gu M, Jin, Klinman M, Wahl SM (1998) Plasmid DNA encoding TGFβ1 suppresses chronic disease in a streptococcal cell wall-induced arthritis model. J Clin Invest 101:1 Wang Q, Finer MH (1996) 2nd-generation adenovirus vectors. Nat Med 2:714 Whalen JD, Carlos CA, Robbins PD, Evans CH (1997) Periarticular gene therapy with viral IL-10 can prevent collagen-induced arthritis in mice. Arthritis Rheum 40:766 Williams RO, Feldmann M, Maini RN (1992) Anti-TNF ameliorates joint disease in murine collagen-induced arthritis. Proc Natl Acad Sci USA 89:9784 Wilson JM (1996) Adenoviruses as gene delivery vehicles. N Engl J Med 334:1185 Wolff JA, Malone RW, Williams P, Wang C, Acsadi G, Jani A, Felgner PL (1990) Direct gene transfer into mouse muscle in vivo. Science 247:1465 Xiao X, Li J, McCown TJ, Samulski RJ (1997) Gene transfer by adeno-associated virus vectors into the central nervous system. Exp Neurol 144:113 Xiao XA, Li JA, Samulski RJ (1996) Efficient long-term gene-transfer into muscle-tissue of immunocompetent mice by adeno-associated virus vector. J Virol 70:8098 Yovandich J, Omalley B, Sikes M, Ledley FD (1995) Gene-transfer to synovial-cells by intraarticular administration of plasmid DNA. Hum Gene Ther 6:603 Zhang H, Yang Y, Horton JL, Samoilova EB, Judge TA, Turka IA, Wilson JM, Chen Y (1997) Amelioration of collagen-induced arthritis by CD95 (Apo-1/Fas)-ligand gene transfer. J Clin Invest 100:1951