Targeted cellular immunotherapy for leukemia patients

Greiner, 2008, Leukemia-associated antigens are critical for the proliferation of acute myeloid leukemia cells, Clin Cancer Res, 14, 7161, 10.1158/1078-0432.CCR-08-1102 Schmitt, 2009, Peptide vaccines for patients with acute myeloid leukemia, Expert Rev Vaccines, 8, 1, 10.1586/erv.09.90 Schmitt, 2008, RHAMM-R3 peptide vaccination in patients with acute myeloid leukemia, myelodysplastic syndrome, and multiple myeloma elicits immunologic and clinical responses, Blood, 111, 1357, 10.1182/blood-2007-07-099366 Oka, 2004, Induction of WT1 (Wilms′ tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression, Proc Natl Acad Sci, 101, 13885, 10.1073/pnas.0405884101 Rezvani, 2008, PR1 vaccination in myeloid malignancies, Expert Rev Vaccines, 7, 867, 10.1586/14760584.7.7.867 Miwa, 1992, Expression of the Wilms′ tumor gene (WT1) in human leukemias, Leukemia, 6, 405 Cilloni, 2008, Early prediction of treatment outcome in acute myeloid leukemia by measurement of WT1 transcript levels in peripheral blood samples collected after chemotherapy, Haematologica, 93, 921, 10.3324/haematol.12165 Kolb, 1999, Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients, Blood, 76, 2462, 10.1182/blood.V76.12.2462.2462 Kolb, 2008, Graft-versus-leukemia effects of transplantation and donor lymphocytes, Blood, 112, 4371, 10.1182/blood-2008-03-077974 Cobbold, 2005, Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA-peptide tetramers, J Exp Med, 202, 379, 10.1084/jem.20040613 Sun, 2009, Recombinant human granulocyte colony-stimulating factor significantly decreases the expression of CXCR3 and CCR6 on T cells and preferentially induces T helper cells to a T helper 17 phenotype in peripheral blood harvests, Biol Blood Marrow Transplant, 15, 835, 10.1016/j.bbmt.2009.03.016 Neudorfer, 2007, Reversible HLA multimers (Streptamers) for the isolation of human cytotoxic T lymphocytes functionally active against tumor- and virus-derived antigens, J Immunol Methods, 320, 119, 10.1016/j.jim.2007.01.001 Casalegno-Garduño, 2010, Multimer technologies for detection and adoptive transfer of antigen-specific T cells, Cancer Immunol Immunother, 59, 195, 10.1007/s00262-009-0778-4 Schmitt A, Tonn T, Busch D, et al. Adoptive transfer and consequential selective reconstitution of streptamer-selected cytomegalovirus-specific CD8+ T cells leads to enduring virus clearance in patients after allogeneic stem cell transplantation. In: 50th ASH Annual meeting blood, vol. 112; 2008. p. 1181. Chrisp, 1991, Foscarnet: a review of its antiviral activity, pharmacokinetic properties and therapeutic use in immunocompromised patients with cytomegalovirus retinitis, Drugs, 41, 104, 10.2165/00003495-199141010-00009 Faulds, 1990, Ganciclovir: a review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in cytomegalovirus infections, Drugs, 39, 597, 10.2165/00003495-199039040-00008 Wang, 2009, Generation of leukemia antigen-specific donor lymphocyte infusions powered by streptamer-based selection, Bone Marrow Transplant, 43, S73 Cilloni, 2002, Quantitative assessment of WT1 expression by real time quantitative PCR may be a useful tool for monitoring minimal residual disease in acute leukemia patients, Leukemia, 16, 2115, 10.1038/sj.leu.2402675 Nowakowska-Kopera, 2009, Wilms′ tumor gene 1 expression analysis by real-time quantitative polymerase chain reaction for monitoring of minimal residual disease in acute leukemia, Leukemia Lymphoma, 50, 1326, 10.1080/10428190903050021