Predicting pharmacokinetic behaviour of drug release from drug-eluting embolization beads using in vitro elution methods

Ahnfelt, 2016, In vitro release mechanisms of doxorubicin from a clinical bead drug-delivery system, J. Pharm. Sci., 105, 3387, 10.1016/j.xphs.2016.08.011 Ahnfelt, 2018, Single bead investigation of a clinical drug delivery system – a novel release mechanism, J. Control. Release, 292, 235, 10.1016/j.jconrel.2018.11.011 Amyot, 2002, A new experimental method for the evaluation of the release profiles of drug-loaded microbeads designed for embolisation, ITBM-RBM, 23, 285, 10.1016/S1297-9562(02)80054-7 Andhariya, 2017, Development of in vitro-in vivo correlation of parenteral naltrexone loaded polymeric microspheres, J. Control. Release, 255, 27, 10.1016/j.jconrel.2017.03.396 Ashrafi, 2017, Characterization of a novel intrinsically radiopaque drug-eluting bead for image-guided therapy: DC bead LUMI™, J. Control. Release, 250, 36, 10.1016/j.jconrel.2017.02.001 Biondi, 2013, Investigation of the mechanisms governing doxorubicin and irinotecan release from drug-eluting beads: mathematical modeling and experimental verification, J. Mater. Sci. Mater. Med., 24, 2359, 10.1007/s10856-013-4992-4 Boulin, 2014, Idarubicin-loaded beads for chemoembolisation of hepatocellular carcinoma: results of the IDASPHERE phase I trial, Aliment. Pharmacol. Ther., 39, 1301, 10.1111/apt.12746 Caine, 2017, Gel phantom for real-time in vitro spatiotemporal diffusion of doxorubicin from radiopaque and non-radiopaque drug eluting beads introduction, J. Vasc. Interv. Radiol., 28, e47 Caine, 2017, Review of the development of methods for characterization of microspheres for use in embolotherapy: translating Bench to Cathlab, Adv. Healthc. Mater., 6, 10.1002/adhm.201601291 Caine, 2017, Impact of yttrium-90 microsphere density, flow dynamics, and administration technique on spatial distribution: analysis using an in vitro model, J. Vasc. Interv. Radiol., 28, 260, 10.1016/j.jvir.2016.07.001 ClinicalTrials.gov de Baere, 2016, An in vitro evaluation of four types of drug-eluting microspheres loaded with doxorubicin, J. Vasc. Interv. Radiol., 27, 1425, 10.1016/j.jvir.2016.05.015 Denys, 2017, Vandetanib-eluting radiopaque beads: in vivo pharmacokinetics, safety and toxicity evaluation following swine liver embolization, Theranostics, 7, 2164, 10.7150/thno.19652 Drugbank Dubbelboer, 2014, The effects of lipiodol and cyclosporin A on the hepatobiliary disposition of doxorubicin in pigs, Mol. Pharm., 11, 1301, 10.1021/mp4007612 Duran, 2016, A novel inherently radiopaque bead for transarterial embolization to treat liver cancer - a pre-clinical study, Theranostics, 6, 28, 10.7150/thno.13137 Facciorusso, 2018, Drug-eluting beads transarterial chemoembolization for hepatocellular carcinoma: current state of the art, World J. Gastroenterol., 24, 161, 10.3748/wjg.v24.i2.161 FDA, 1997 Fuchs, 2014, Drug-eluting beads loaded with antiangiogenic agents for chemoembolization: in vitro sunitinib loading and release and in vivo pharmacokinetics in an animal model, J. Vasc. Interv. Radiol., 25, 379, 10.1016/j.jvir.2013.11.039 Fuchs, 2015, Sunitinib-eluting beads for chemoembolization: methods for in vitro evaluation of drug release, Int. J. Pharm., 482, 68, 10.1016/j.ijpharm.2014.11.041 Gonzalez, 2008, Doxorubicin eluting beads-2: methods for evaluating drug elution and in-vitro:in-vivo correlation, J. Mater. Sci. Mater. Med., 19, 767, 10.1007/s10856-006-0040-y Gustafson, 2002, Doxorubicin pharmacokinetics: macromolecule binding, metabolism, and excretion in the context of a physiologic model, J. Pharm. Sci., 91, 1488, 10.1002/jps.10161 Hagan, 2017, Preparation and characterisation of vandetanib-eluting radiopaque beads for locoregional treatment of hepatic malignancies, Eur. J. Pharm. Sci., 101, 22, 10.1016/j.ejps.2017.01.033 Jordan, 2010, Comparative study of chemoembolization loadable beads: in vitro drug release and physical properties of DC bead and hepasphere loaded with doxorubicin and irinotecan, J. Vasc. Interv. Radiol., 21, 1084, 10.1016/j.jvir.2010.02.042 Lahti, 2015, Sorafenib loaded drug-eluting beads: loading and eluting kinetics and in vitro viability study, J. Vasc. Interv. Radiol., 26, S80, 10.1016/j.jvir.2014.12.223 Lammer, 2010, Prospective randomized study of doxorubicin-eluting-bead embolization in the treatment of hepatocellular carcinoma: results of the PRECISION V study, Cardiovasc. Intervent. Radiol., 33, 41, 10.1007/s00270-009-9711-7 Lencioni, 2012, Chemoembolization for hepatocellular carcinoma, Semin. Oncol., 39, 503, 10.1053/j.seminoncol.2012.05.004 Lewis, 2009, DC Bead™: a major development in the toolbox for the interventional oncologist, Expert Rev. Med. Devices, 6, 389, 10.1586/erd.09.20 Martin, 2009, Transarterial chemoembolization of metastatic colorectal carcinoma with drug-eluting beads, irinotecan (DEBIRI): multi-institutional registry, J. Oncol., 2009, 10.1155/2009/539795 Martin, 2011, Hepatic intra-arterial injection of drug-eluting bead, irinotecan (DEBIRI) in unresectable colorectal liver metastases refractory to systemic chemotherapy: results of multi-institutional study, Ann. Surg. Oncol., 18, 192, 10.1245/s10434-010-1288-5 Martin, 2012, Optimal outcomes for liver-dominant metastatic breast cancer with transarterial chemoembolization with drug-eluting beads loaded with doxorubicin, Breast Cancer Res. Treat., 132, 753, 10.1007/s10549-011-1926-z Namur, 2010, Drug-eluting beads for liver embolization: concentration of doxorubicin in tissue and in beads in a pig model, J. Vasc. Interv. Radiol., 21, 259, 10.1016/j.jvir.2009.10.026 Nicolini, 2010, Transarterial chemoembolization with epirubicin-eluting beads versus transarterial embolization before liver transplantation for hepatocellular carcinoma, J. Vasc. Interv. Radiol., 21, 327, 10.1016/j.jvir.2009.10.038 Nicolini, 2011, Drug delivery embolization systems: a physician's perspective, Expert Opin. Drug Deliv., 8, 1071, 10.1517/17425247.2011.590472 Qureshi, 2010, In vitro-in vivo correlation (IVIVC) and determining drug concentrations in blood from dissolution testing - a simple and practical approach, Open Drug Delivery J., 4, 38, 10.2174/1874126601004020038 Reich, 1979, Mathematical model for adriamycin (doxorubicin) pharmacokinetics, Cancer Chemother. Pharmacol., 3, 125, 10.1007/BF00254984 Song, 2017, Conventional vs drug-eluting beads transarterial chemoembolization for hepatocellular carcinoma, World J. Hepatol., 9, 808, 10.4254/wjh.v9.i18.808 Swaine, 2016, Evaluation of ion exchange processes in drug-eluting embolization beads by use of an improved flow-through elution method, Eur. J. Pharm. Sci., 93, 351, 10.1016/j.ejps.2016.08.020 Taylor, 2007, Irinotecan drug eluting beads for use in chemoembolization: in vitro and in vivo evaluation of drug release properties, Eur. J. Pharm. Sci., 30, 7, 10.1016/j.ejps.2006.09.002