Inhibition of inositol monophosphatase (IMPase) at the calbindin-D28k binding site: Molecular and behavioral aspects

Airaksinen, 1997, Ataxia and altered dendritic calcium signaling in mice carrying a targeted null mutation of the calbindin D28k gene, Proc. Natl. Acad. Sci. USA, 94, 1488, 10.1073/pnas.94.4.1488 Atack, 1997, Inositol monophosphatase inhibitors—lithium mimetics?, Med. Res. Rev., 17, 215, 10.1002/(SICI)1098-1128(199703)17:2<215::AID-MED3>3.0.CO;2-2 Atack, 1995, Structure and mechanism of inositol monophosphatase, FEBS Lett., 361, 1, 10.1016/0014-5793(95)00063-F Atack, 1995, Inositol monophosphatase—a putative target for Li+ in the treatment of bipolar disorder, Trends Neurosci., 18, 343, 10.1016/0166-2236(95)93926-O Barski, 2003, Calbindin in cerebellar Purkinje cells is a critical determinant of the precision of motor coordination, J. Neurosci., 23, 3469, 10.1523/JNEUROSCI.23-08-03469.2003 Beasley, 2002, Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins, Biol. Psychiatry, 52, 708, 10.1016/S0006-3223(02)01360-4 Belmaker, 2007, Lithium-pilocarpine seizures as a model for lithium action in mania, Neurosci. Biobehav. Rev., 31, 843, 10.1016/j.neubiorev.2007.05.001 Berggard, 2002, Myo-inositol monophosphatase is an activated target of calbindin D28k, J. Biol. Chem., 277, 41954, 10.1074/jbc.M203492200 Berggard, 2002, Calbindin D28k exhibits properties characteristic of a Ca2+ sensor, J. Biol. Chem., 277, 16662, 10.1074/jbc.M200415200 Berridge, 1989, The Albert Lasker Medical Awards. Inositol trisphosphate, calcium, lithium, and cell signaling, J. Am. Med. Assoc., 262, 1834, 10.1001/jama.1989.03430130110043 Berridge, 1982, Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands, Biochem. J., 206, 587, 10.1042/bj2060587 Bersudsky, 2007, Lithium's effect in forced-swim test is blood level dependent but not dependent on weight loss, Behav. Pharmacol., 18, 77, 10.1097/FBP.0b013e32801416ed Blatow, 2003, Ca2± buffer saturation underlies paired pulse facilitation in calbindin-D28k-containing terminals, Neuron, 38, 79, 10.1016/S0896-6273(03)00196-X Celio, 1990, Calbindin D-28k and parvalbumin in the rat nervous system, Neuroscience, 35, 375, 10.1016/0306-4522(90)90091-H Cotter, 2002, The density and spatial distribution of GABAergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia, Biol. Psychiatry, 51, 377, 10.1016/S0006-3223(01)01243-4 Crawley, 1999, Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests, Brain Res., 835, 18, 10.1016/S0006-8993(98)01258-X Cryns, 2008, IMPA1 is essential for embryonic development and lithium-like pilocarpine sensitivity, Neuropsychopharmacology, 33, 674, 10.1038/sj.npp.1301431 DeLano, 2002 Fauroux, 1999, Inhibitors of inositol monophosphatase, J. Enzyme Inhib., 14, 97, 10.3109/14756369909036548 Feeney, 1981, Responses to cortical injury: I .Methodology and local effects of contusions in the rat, Brain Res., 211, 67, 10.1016/0006-8993(81)90067-6 Ganzhorn, 1998, Inhibition of myo-inositol monophosphatase isoforms by aromatic phosphonates, Bioorg. Med. Chem., 6, 1865, 10.1016/S0968-0896(98)00148-5 Gill, 2005, High-resolution structure of myo-inositol monophosphatase, the putative target of lithium therapy, Acta Crystallogr. D Biol. Crystallogr., 61, 545, 10.1107/S0907444905004038 Gilon, 1991, Backbone cyclization: a new method for conferring conformational constraint on peptides, Biopolymers, 31, 745, 10.1002/bip.360310619 Gonzalez-Albo, 2001, The human temporal cortex: characterization of neurons expressing nitric oxide synthase, neuropeptides and calcium-binding proteins, and their glutamate receptor subunit profiles, Cereb. Cortex, 11, 1170, 10.1093/cercor/11.12.1170 Gould, 2007, Animal models of bipolar disorder and mood stabilizer efficacy: a critical need for improvement, Neurosci. Biobehav. Rev., 31, 825, 10.1016/j.neubiorev.2007.05.007 Hallcher, 1980, The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain, J. Biol. Chem., 255, 10896, 10.1016/S0021-9258(19)70391-3 Harwood, 2003, Search for a common mechanism of mood stabilizers, Biochem. Pharmacol., 66, 179, 10.1016/S0006-2952(03)00187-4 Hess, 2007, Effect of structural and conformation modifications, including backbone cyclization, of hydrophilic hexapeptides on their intestinal permeability and enzymatic stability, J. Med. Chem., 50, 6201, 10.1021/jm070836d Hess, 2008, Backbone cyclic peptidomimetic melanocortin-4 receptor agonist as a novel orally administrated drug lead for treating obesity, J. Med. Chem., 51, 1026, 10.1021/jm701093y Iritani, 2001, Relationship of calbindin D28K-immunoreactive cells and neuropathological changes in the hippocampal formation of Alzheimer's disease, Neuropathology, 21, 162, 10.1046/j.1440-1789.2001.00393.x Kasher, 1999, Miniaturized proteins: the backbone cyclic proteinomimetic approach, J. Mol. Biol., 292, 421, 10.1006/jmbi.1999.3053 Katchalski-Katzir, 1992, Molecular surface recognition: determination of geometric fit between proteins and their ligands by correlation techniques, Proc. Natl. Acad. Sci. USA, 89, 2195, 10.1073/pnas.89.6.2195 Kessler, 2010, Improvement of drug-like properties of peptides: the somatostatin paradigm, Expert Opin. Drug Discovery, 5, 655, 10.1517/17460441.2010.493935 Klein, 1996, A molecular mechanism for the effect of lithium on development, Proc. Natl. Acad. Sci. USA, 93, 8455, 10.1073/pnas.93.16.8455 Kofman, 1993, Ziskind-Somerfeld Research Award 1993. Biochemical, behavioral, and clinical studies of the role of inositol in lithium treatment and depression, Biol. Psychiatry, 34, 839, 10.1016/0006-3223(93)90052-F Kojetin, 2006, Structure, binding interface and hydrophobic transitions of Ca2+-loaded calbindin-D(28K), Nat. Struct. Mol. Biol., 13, 641, 10.1038/nsmb1112 Lambers, 2006, Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport, Embo J., 25, 2978, 10.1038/sj.emboj.7601186 Leech, 1993, Chemical and kinetic mechanism of the inositol monophosphatase reaction and its inhibition by Li+, Eur. J. Biochem., 212, 693, 10.1111/j.1432-1033.1993.tb17707.x Mattson, 1991, Evidence for calcium-reducing and excito-protective roles for the calcium-binding protein calbindin-D28k in cultured hippocampal neurons, Neuron, 6, 41, 10.1016/0896-6273(91)90120-O Mikkonen, 1997, Distribution of parvalbumin-, calretinin-, and calbindin-D28k-immunoreactive neurons and fibers in the human entorhinal cortex, J. Comp. Neurol., 388, 64, 10.1002/(SICI)1096-9861(19971110)388:1<64::AID-CNE5>3.0.CO;2-M O'Brien, 2004, Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium, J. Neurosci., 24, 6791, 10.1523/JNEUROSCI.4753-03.2004 Ohnishi, 2007, Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1, J. Biol. Chem., 282, 637, 10.1074/jbc.M604474200 Okumu, 1997, Effect of restricted conformational flexibility on the permeation of model hexapeptides across Caco-2 cell monolayers, Pharm. Res., 14, 169, 10.1023/A:1012092409216 Ovadia, 2009, The effect of backbone cyclization on PK/PD properties of bioactive peptide-peptoid hybrids: the melanocortin agonist paradigm, Bioorg. Med. Chem., 18, 580, 10.1016/j.bmc.2009.12.010 Pauletti, 1997, Esterase-sensitive cyclic prodrugs of peptides: evaluation of a phenylpropionic acid promoiety in a model hexapeptide, Pharm. Res., 14, 11, 10.1023/A:1012091014242 Quiroz, 2010, Novel insights into lithium's mechanism of action: neurotrophic and neuroprotective effects, Neuropsychobiology, 62, 50, 10.1159/000314310 Reilly, 2009, Protein-protein interactions as therapeutic targets in neuropsychopharmacology, Neuropsychopharmacology, 34, 247, 10.1038/npp.2008.167 Ren, 2001, Amino acid sequence requirements of peptides that inhibit polyglutamine-protein aggregation and cell death, Biochem. Biophys. Res. Commun., 288, 703, 10.1006/bbrc.2001.5783 Schmidt, 2005, Calbindin D28k targets myo-inositol monophosphatase in spines and dendrites of cerebellar Purkinje neurons, Proc. Natl. Acad. Sci. USA, 102, 5850, 10.1073/pnas.0407855102 Shaltiel, 2001, Inositol monophosphatase activity in brain and lymphocyte-derived cell lines of bipolar, schizophrenic and unipolar patients, World J. Biol. Psychiatry, 2, 95, 10.3109/15622970109027499 Shamir, 2005, Interaction of calbindin D and inositol monophosphatase in human postmortem cortex: possible implications for bipolar disorder, Bipolar Disord., 7, 42, 10.1111/j.1399-5618.2004.00162.x Sharma, 2007, Design, synthesis, and evaluation of linear and cyclic peptide ligands for PDZ10 of the multi-PDZ domain protein MUPP1, Biochemistry, 46, 12709, 10.1021/bi7008135 Sooy, 1999, Calbindin-D(28k) controls [Ca2+]i and insulin release. Evidence obtained from calbindin-d(28k) knockout mice and beta cell lines, J. Biol. Chem., 274, 34343, 10.1074/jbc.274.48.34343 Thulin, 1999, Expression and purification of human calbindin D28k, Protein Expression Purif., 15, 265, 10.1006/prep.1999.1028 Wells, 2007, Reaching for high-hanging fruit in drug discovery at protein-protein interfaces, Nature, 450, 1001, 10.1038/nature06526 Williams, 2002, A common mechanism of action for three mood-stabilizing drugs, Nature, 417, 292, 10.1038/417292a