The relevance of tumour pH to the treatment of malignant disease

Radiotherapy and Oncology - Tập 2 - Trang 343-366 - 1984
J.L. Wike-Hooley1, J. Haveman2, H.S. Reinhold3
1Department of Hyperthermia, Rotterdamsch Radio-Therapeutisch Instituut, Groene Hilledijk 301, 3075 EA Rotterdam, The Netherlands
2Department of Radiotherapy, Academisch Medisch Centrum, Amsterdam, The Netherlands
3Department of Experimental Radiotherapy, Erasmus University, Rotterdam, The Netherlands

Tài liệu tham khảo

Adams, 1980, Toxicity of nitro compounds towards hypoxic mammalian cells in vitro. Dependence on reduction potential, J. Natl. Cancer Inst., 64, 555 Albers, 1981, Effect of CO2 and lactic acid on intracellular pH of ascites tumor cells, Respir. Physiol., 45, 273, 10.1016/0034-5687(81)90011-6 Algire, 1952, Vascular reactions of normal and malignant tissues in vivo. IV. The effect of peripheral hypotension on transplanted tumors, J. Natl. Cancer Inst., 12, 399 Anghileri, 1975, Tumor growth inhibition by ammonium chloride-induced acidosis, Int. J. Clin. Pharmacol., 12, 320 Ashby, 1966, pH studies in human malignant tumours, Lancet, ii, 312, 10.1016/S0140-6736(66)92598-0 Baba, 1978, 5 Fluorouracil O-β-d-Glucuronide as a newly synthesized chemically modified, non toxic anticancer drug, Gann, 69, 283 Bear, 1977, The effect of medium pH on rate of growth, neurite formation and acetylcholinesterase activity in mouse neuroblastoma cells in culture, J. Cell. Physiol., 91, 63, 10.1002/jcp.1040910107 Belli, 1963, Influence of temperature on the radiation response of mammalian cells in tissue culture, Radiat. Res., 18, 272, 10.2307/3571495 Bhat, 1980, Changes in tissue (tpH) and blood lactate during hypoxia and recovery in puppies, Pediat. Res., 14, 591 Bhuyan, 1977, Cell cycle-related cellular lethality, 373 Bichel, 1977, Hyperthermic effect on exponential and plateau ascites tumor cells in vitro dependent on environmental pH, Radiat. Res., 70, 449, 10.2307/3574602 Bicher, 1980, Effects of hyperthermia on normal and tumour microenvironment, Radiology, 137, 523, 10.1148/radiology.137.2.7433686 Bicker, 1974, Application of β-d-glucuronides and glucose together suggests a new direction for cancer chemotherapy, Nature, 252, 726, 10.1038/252726a0 Born, 1981, Effect of different physiological conditions on the action of Adriamycin on Chinese hamster cells in vitro, Br. J. Cancer, 44, 241, 10.1038/bjc.1981.175 Brodie, 1957, Some physico-chemical factors in drug action, J. Pharm. London, 9, 345, 10.1111/j.2042-7158.1957.tb12289.x Buelke-Sam, 1978, Comparative stability of physiological parameters during sustained anaesthesia in rats, Lab. Anim. Sci., 28, 157 Busse, 1981, Intratumour pH distribution—a function of tumor growth stage?, Pflugers Arch., 389, R55 Ceccarini, 1975, Effect of pH on plating efficiency, serum requirement and incorporation of radioactive precursors into human cells, In Vitro, 11, 78, 10.1007/BF02624079 Connors, 1964, The effect of glucose pre-treatment on the carcinostatic and toxic activities of some alkylating agents, Biochem. Pharmacol., 13, 395, 10.1016/0006-2952(64)90158-3 Couch, 1971, Muscle surface pH as an index of peripheral perfusion in man, Ann. Surg., 173, 173, 10.1097/00000658-197102000-00001 Dewey, 1980, Rationale for use of hyperthermia in cancer therapy, Ann. N.Y. Acad. Sci., 335, 372, 10.1111/j.1749-6632.1980.tb50762.x Dickson, 1976, The sensitivity of a malignant cell line to hyperthermia (42°C) at low intracellular pH, Br. J. Cancer, 34, 262, 10.1038/bjc.1976.161 Dickson, 1979, Effects of hyperglycemia and hyperthermia on the pH, glycolysis and respiration of the Yoshida sarcoma in vivo, J. Natl. Canc. Inst., 63, 1371 Dickson, J. A. and Calderwood, S. K. Thermosensitivityof neoplastic tissue in vivo. In: Hyperthermia in Cancer Therapy, pp. 63–140. Editor: F. K. Storm. G. K. Hall, Boston, MA, 1983. Dunn, 1978, The relationship between tissue and arterial pH in hypercarbic rabbits, Arch. Gynecol., 226, 31, 10.1007/BF02116724 Eagle, 1973, The effect of environmental pH on the growth of normal and malignant cells, J. Cell. Physiol., 82, 1, 10.1002/jcp.1040820102 Eden, 1955, The pH of rat tumours measured in vivo, J. Natl. Cancer Inst., 16, 541 Euler, 1974, Wirkung von Temperatur, pH und Thio-Tepa auf Angehraten und Thymidineinbau van aszitestumorcellen, Wien. Klin. Wochenschr., 86, 211 Evanochko, 1983, In vivo 31P NMR study of the metabolism of murine mammary 16/C adenocarcinoma and its response to chemotherapy, X-radiation and hyperthermia, Proc. Natl. Acad. Sci. U.S.A., 80, 334, 10.1073/pnas.80.2.334 Filler, 1971, Muscle surface pH as a monitor of tissue perfusion and acid-base status, J. Pediat. Surg., 6, 535, 10.1016/0022-3468(71)90375-7 Freeman, 1977, Effect of pH on hyperthermic cell survival, J. Natl. Cancer Inst., 58, 1837, 10.1093/jnci/58.6.1837 Freeman, 1980, The effect of pH on cell lethality induced by hyperthermic treatment, Cancer, 45, 2291, 10.1002/1097-0142(19800501)45:9<2291::AID-CNCR2820450912>3.0.CO;2-X Freeman, 1981, The effect of pH on hyperthermic and X-ray induced cell killing, Int. J. Radiat. Oncol. Biol. Phys., 7, 211, 10.1016/0360-3016(81)90439-9 Freeman, 1981, The influence of environmental pH on the interaction and repair of heat and radiation damage, Int. J. Radiat. Oncol. Biol. Phys., 7, 761, 10.1016/0360-3016(81)90470-3 Freeman, 1984, An acidic extracellular environment reduces the fixation of radiation damage, Radiat. Res., 97, 154, 10.2307/3576196 Gebert, 1973, An implantable glass electrode used for pH measurement in working skeletal muscle, J. Appl. Physiol., 34, 122, 10.1152/jappl.1973.34.1.122 Gerweck, 1974, Killing of Chinese Hamster cells in-vitro by heating under hypoxic or aerobic conditions, Eur. J. Cancer, 10, 691, 10.1016/0014-2964(74)90009-7 Gerweck, 1977, Modification of cell lethality at elevated temperatures. The pH effect, Radiat. Res., 70, 224, 10.2307/3574745 Gerweck, 1979, Response of cells to hyperthermia under acute and chronic hypoxic conditions, Cancer Res., 39, 966 Gerweck, 1980, Influence of pH on the response of cells to single and split doses of hyperthermia, Cancer Res., 40, 4019 Gerweck, 1981, Influence of pH on the thermal sensitivity of cultured human glioblastoma cells, Cancer Res., 41, 845 Gerweck, 1983, Effects of pH on single or fractionated heat treatments at 42–45°, Cancer Res., 43, 1163 Gillies, 1982, 31P Nuclear magnetic resonance evidence for the regulation of intracellular pH by Ehrlich ascites tumour cells, J. Cell. Biol., 95, 24, 10.1083/jcb.95.1.24 Goldin, 1981, The effect of reduced pH on the induction of thermotolerance, Radiology, 141, 505, 10.1148/radiology.141.2.7291581 Gonzalez-Mendez, 1982, Continuous flow NMR culture system for mammalian cells, Biochim. Biophys. Acta, 720, 274, 10.1016/0167-4889(82)90051-9 Gullino, 1964, The interstitial fluid of solid tumours, Cancer Res., 24, 780 Gullino, 1965, Modifications of the acid-base status of the internal milieu of tumours, J. Natl. Cancer Inst., 34, 857 Hahn, 1982, Mechanisms of heat action, 87 Harguindey, 1979, Effects of systemic acidification of mice with sarcoma 180, Cancer Res., 39, 4364 Harrison, 1979, Micro-electrode measurement of skin pH in humans during ischaemia, hypoxia and local hyperthermia, J. Physiol., 291, 339, 10.1113/jphysiol.1979.sp012817 Haveman, 1979, The pH of the cytoplasm as an important factor in the survival of in vitro cultured malignant cells after hyperthermia. Effects of carbonylcyanide 3-chlorophenylhydrazone, Eur. J. Cancer, 15, 1281, 10.1016/0014-2964(79)90255-X Haveman, 1980, The influence of pH on the survival after X-irradiation of cultured malignant cells. Effects of carbonylcyanide 3-chlorophenylhydrazone, Int. J. Radiat. Biol., 37, 201, 10.1080/09553008014550241 Haveman, 1980, The capacity of lysosomes of cultured mammalian cells to accumulate acridine orange is destroyed by hyperthermia, Cell Tiss. Res., 213, 343, 10.1007/BF00234792 Haveman, 1983, Influence of pH and thermotolerance on the enhancement of X-ray induced inactivation of cultured mammalian cells by hyperthermia, Int. J. Radiat. Biol., 43, 281, 10.1080/09553008314550321 Hofer, 1980, Tumour cell sensitivity to hyperthermia as a function of extracellular and intracellular pH, J. Natl. Cancer Inst., 65, 621 Holahan, 1982, Enhancement of survival of CHO cells by acidic pH after X irradiation, Radiat. Res., 89, 433, 10.2307/3575789 Hult, 1976, Dissociation of 5-Fluorouracil uptake from intracellular pH in Walker 256 carcinosarcoma, Cancer Treat. Rep., 60, 867 Jähde, 1982, Tumor-selective modification of cellular microenvironment in vivo: effect of glucose infusion on the pH in normal and malignant rat tissues, Cancer Res., 42, 1505 Jähde, 1982, pH distributions in transplanted neural tumors and normal tissues of BDIX rats as measured with pH micro electrodes, Cancer Res., 42, 1498 Jennische, 1978, Correlation between tissue pH, cellular transmembrane potentials and cellular energy metabolism during shock and during ischemia, Circ. Shock, 5, 251 Kahler, 1943, Hydrogen ion concentration of normal liver and hepatic tumours, J. Natl. Cancer Inst., 3, 495 Kahler, 1962, pH of rat tumours and some comparisons with the Lissamine-green circulation test, J. Natl. Cancer Inst., 28, 561 Keech, 1979, The effect of hyperthermia on activation of lysosomal enzymes in Hela cells, Eur. J. Cancer, 5, 1025, 10.1016/0014-2964(79)90290-1 Kost, 1978, Medial gastrocnemius and soleus muscle surface pH responses to hemorrhagic shock, Fed. Proc., 37, 774 Kung, 1963, Potentiation of 5-Fluorouracil inhibition of Flexner-Jobling carcinoma by glucose, Science, 141, 627, 10.1126/science.141.3581.627 Lemieux, 1969, Surface pH and redox potential of skeletal muscle in graded hemorrhage, Surgery, 65, 457 Li, 1980, A proposed operational model of thermotolerance based on effects of nutrients and the initial treatment temperature, Cancer Res., 40, 4501 Li, 1980, Recovery of cells from heat-induced potentially lethal damage: effects of pH and nutrient environment, Int. J. Radiat. Oncol. Biol. Phys., 6, 577, 10.1016/0360-3016(80)90385-5 Lunec, 1980, The influence of pH on the enhancement of radiation damage by hyperthermia, Int. J. Radiat. Biol., 38, 567, 10.1080/09553008014551381 Madoc-Jones, 1974, Site of action of cytotoxic agents in the cell cycle, 205 Mendonca, 1983, Extracellular pH and the cell-cycle: possible links to radioresistance, B7 Meyer, 1948, pH Studies of malignant tissues in human beings, Cancer Res., 8, 513 Meyer, 1979, The thermal response of mouse adenocarcinoma cells at low pH, Eur. J. Cancer, 15, 1219, 10.1016/0014-2964(79)90247-0 Mikkelsen, 1982, Transmembrane ion gradients and thermochemotherapy, 103 Mivechi, 1981, Influence of hypoxia and acidity on thermal radiosensitization and direct heat-induced death of BP-8 sarcoma cells, Radiology, 138, 465, 10.1148/radiology.138.2.7455132 Müller-Klieser, 1981, Tissue pH-distribution within malignant tumors as measured with antimony microelectrodes, Adv. Physiol. Sci., 25, 253 Naeslund, 1953, Investigations on the pH of malignant tumours in mice and humans after the administration of glucose, Acta Obstet. Gynecol. Scand., 32, 359, 10.3109/00016345309157588 Ng, 1982, 31P NMR Spectroscopy of in vivo tumours, J. Magn. Reson., 49, 271 Nielsen, 1979, Effect of extracellular pH on thermotolerance and recovery of hyperthermic damage in vitro, Cancer Res., 39, 2772 Nissen, 1981, Influence of pH and serum on the effectivity of antineoplastic agents in vitro, Arch. Geschwulstforsch., 51, 152 O Donnell, 1975, Measurement of percutaneous muscle surface pH, Lancet, ii, 533, 10.1016/S0140-6736(75)90899-5 Overgaard, 1975, Effect of pH on response to hyperthermia, 43 Overgaard, 1976, Influence of extracellular pH on the viability and morphology of tumour cells exposed to hyperthermia, J. Natl. Cancer Inst., 56, 1243, 10.1093/jnci/56.6.1243 Overgaard, 1977, The influence of hypoxia and acidity on the hyperthermic response of malignant cells in vitro, Radiology, 123, 511, 10.1148/123.2.511 Overgaard, 1977, Effect of hyperthermia and environmental acidity on the proteolytic activity in murine ascites tumour cells, J. Natl. Cancer Inst., 58, 1159, 10.1093/jnci/58.4.1159 Pampus, 1963, Die Wasserstofionenkonzentration des Hirngewebes bei raumfordernden intracraniellen Prozessen, Acta Neurochir., 11, 305, 10.1007/BF01402010 Pappova, 1982, Oxygen tension and prediction of the radiation response. Polygraphic study in human breast cancer, Neoplasma, 29, 669 Poole, 1967, Intracellular pH of the Ehrlich Ascites Tumor cells as it is affected by sugars and sugar derivatives, J. Biol. Chem., 242, 3731, 10.1016/S0021-9258(18)95870-9 Rajaratnam, 1982, Enhancement of the cytotoxicity of radiosensitizers by modest hyperthermia: the electron affinity relationship, Br. J. Cancer, 46, 912, 10.1038/bjc.1982.301 Rauen, 1964, Die Bildungsgeschwindigkeiten von N-β-Halogenäthylaziridinen aus Bis (β-halogenäthyl)-aminen unter physiologischen Bedingungen, Arzneim. Forsch., 14, 855 Rauen, 1968, Messungen zur Manipulation der Glucose—abhängigen Tumorsäuerung in vivo, Z. Naturforsch., 236, 1461, 10.1515/znb-1968-1109 Ross, 1961, Increased sensitivity of Walker tumours towards aromatic nitrogen mustards carrying basic side chains following glucose pre-treatment, Biochem. Pharmacol., 8, 235, 10.1016/0006-2952(61)90006-5 Ross, 1962, 29 Ross, 1962, 143 Ross, 1962, 195 Röttinger, 1980, Modification of pH induced cellular inactivation by irradiation-glial cells, Int. J. Radiat. Oncol. Biol. Phys., 6, 1659, 10.1016/0360-3016(80)90248-5 Röttinger, 1982, Radioresistance secondary to low pH in human glial cells and Chinese hamster ovary cells, Int. J. Radiat. Oncol. Biol. Phys., 8, 1309, 10.1016/0360-3016(82)90580-6 Rubin, 1974, Interrelationships of glycolysis, sugar transport and the initiation of DNA synthesis in chick embryo cells, Vol I, 801 Sahler, 1969, Glucose-induced pH changes in Ehrlich ascites tumor cells, Gann, 60, 657 Schloerb, 1965, Intracellular pH and buffering capacity of the Walker-256 carcinoma, Surgery, 58, 5 Schmid-Schönbein, 1975, Effect of O-(β-hydroxyethyl)-rutosides on the microrheology of human blood under defined flow conditions, Vasa, 4, 263 Shackney, 1978, Growth rate patterns of solid tumours and their relation to responsiveness to therapy: An analytical review, Ann. Intern. Med., 89, 107, 10.7326/0003-4819-89-1-107 Song, 1980, The effect of hyperthermia on vascular function, pH and cell survival, Radiology, 137, 795, 10.1148/radiology.137.3.7444064 Song, 1982, Physiological factors in hyperthermia, Natl. Cancer Inst. Monogr., 61, 169 Spencer, 1976, l-lactate transport in Ehrlich ascites-tumour cells, Biochem. J., 154, 405, 10.1042/bj1540405 Stamm, 1976, Development of a special electrode for continuous subcutaneous pH measurement in the infant scalp, Am. J. Obstet. Gynecol., 124, 193, 10.1016/S0002-9378(16)33297-5 Steinhagen, 1976, The interstitial pH of the working gastrocnemius muscle of the dog, Pflügers Arch., 367, 151, 10.1007/BF00585151 Stevens, 1950, Sulfapyrazine precipitated in cancer tissue upon repeated glucose injections, Science, 112, 561, 10.1126/science.112.2915.561 Stevens, 1969, Enhancement by glucose of the inhibition of an Ehrlich ascites tumour by tetraazatricyclododecane, Cancer Res., 29, 1132 Stratford, 1977, Effect of hyperthermia on differential cytotoxicity of a hypoxic cell radiosensitizer RO-07-0582 on mammalian cells in vitro, Br. J. Cancer, 35, 307, 10.1038/bjc.1977.44 Sutherland, 1974, Selective chemotherapy of non-cycling cells in an in vitro tumour model, Cancer Res., 34, 3501 Tagashira, 1953, Continual pH measuring by means of inserted microglass electrode in living normal and tumour tissues (1st report), Gann, 44, 63 Tagashira, 1954, Continuous pH measuring by means of microglass electrode inserted in living normal and tumour tissues (IInd report), with an additional report oninteraction of SH-group of animal protein with carcinogenic agent in the carcinogenetic mechanism, Gann, 45, 99 Taylor, 1962, Responses of cells to pH changes in the medium, J. Cell Biol., 15, 201, 10.1083/jcb.15.2.201 Tritton, 1982, The anticancer agent Adriamycin can be actively cytotoxic without entering cells, Science, 217, 248, 10.1126/science.7089561 Trowell, 1953, The effect of environmental factors on the radiosensitivity of lymph nodes cultured in vitro, Br. J. Radiol., 306, 302, 10.1259/0007-1285-26-306-302 Turner, 1979, Increased release of tumour cells by collagenase at acid pH: A possible mechanism for metastasis, Experientia, 35, 1657, 10.1007/BF01953252 Urano, 1980, Response of a spontaneous murine tumour to hyperthermia: factors which modify the thermal response in vivo, Radiat. Res., 83, 312, 10.2307/3575282 Urano, 1983, Effect of hyperglycemia on thermochemotherapy of a spontaneous murine fibrosarcoma, Cancer Res., 43, 3041 Valeriote, 1975, Proliferation-dependent cytotoxicity of anticancer agents: a review, Cancer Res., 35, 2619 Van den Berg, 1982, Tumour pH in Human Mammary Carcinoma, Eur. J. Cancer Clin. Oncol., 18, 457, 10.1016/0277-5379(82)90114-6 Vaupel, 1981, Heterogeneous oxygen partial pressure and pH distribution in CH3 mouse mammary adenocarcinoma, Cancer Res., 41, 2008 Vaupel, 1982, Einfluss einer lokalisierten Mikrowellen-Hyperthermie auf die pH-Verteilung in bosartigen Tumoren, Strahlentherapie, 158, 168 Vaupel, 1983, Blood flow, tissue oxygenation, and pH distribution in malignant tumours upon localized hyperthermia, Strahlentherapie, 159, 73 Vidyasagar, 1979, Continuous tissue pH (tph) monitoring in sick neonates, Pediat. Res., 13, 509 Voegtlin, 1934, The hydrogen-ion concentration of mammalian voluntary muscle under various conditions, Am. J. Physiol., 107, 539, 10.1152/ajplegacy.1934.107.3.539 Voegtlin, 1935, Experimental studies in cancer. I. The influence of the parenteral administration of certain, sugars on the pH of malignant tumours, Natl. Inst. Health Bull., 164, 1 Von Ardenne, 1972, Selective multiphase cancer therapy: conceptual aspects and experimental basis, Adv. Pharmacol., 10, 339, 10.1016/S1054-3589(08)60527-X Von Ardenne, 1975, Verstärkung der mit Glukose infusion erzielbaren Tumorübersaüerung in vivo durch Amygdalin und β-Glukosidase, Arch. Geschwulstforsch., 45, 135 Von Ardenne, 1976, Verstärkung der mit Glukoseinfusion erzielbaren Tumorübersaüerung in vivo durch NAD, Arch. Geschwulstforsch, 46, 197 Von Ardenne, 1977, Berechnung des pH-Profils im Interkapillarraum der Krebsgewebe für die Falle mit und ohne, Langzeit-Glukose-Infusion, Res. Exp. Med., 171, 177, 10.1007/BF01851365 Von Ardenne, 1978, Prinzipien und Konzept 1977 der Krebs-Mehrschritt-Therapie, Arch. Geschwulstforsch., 48, 504 Von Ardenne, 1978, Amplification of the selective tumour acidification by local hyperthermia, Naturwissenschaften, 65, 159, 10.1007/BF00440354 Von Ardenne, 1979, Verstärkung der mit Glucoseinfusion erzielbaren Tumorübersäuerung durch lokale Hyperthermie, Res. Exp. Med. (Berlin), 175, 7, 10.1007/BF01851229 Von Ardenne, 1979, Verstärkung der mit Glukoseinfusion erzielbaren Tumorübersauerung in vivo durch Natriumnitroprussid, Pharmazie, 34, 447 Warburg, 1924, Uber den Stoffwechsel der Carcinomzelle, Biochem. Z., 152, 309 Westra, 1971, Variation in sensitivity to heat shock during the cell cycle of Chinese hamster cells in vitro, Int. J. Radiat. Biol., 19, 467, 10.1080/09553007114550601 Wike-Hooley, 1984, Human tumour pH changes following hyperthermia and radiation therapy, Eur. J. Cancer Clin. Oncol., 20, 619, 10.1016/0277-5379(84)90006-3 Wolpert, 1970, Tissue pH: a new clinical tool, Arch. Surg., 101, 308, 10.1001/archsurg.1970.01340260212031 Woods, 1960, Glucose enhancement of inhibition by fluorinated and normal pyrimidines of tumour glycolysis and transplantability, Proc. Am. Assoc. Cancer Res., 3, 163 Yatvin, 1980, pH sensitive liposomes: possible clinical implications, Science, 210, 1253, 10.1126/science.7434025 Zander, 1972, Influence of intracellular convection on the oxygen release by human erythrocytes, Pflügers Arch., 335, 58, 10.1007/BF00586935