Efficacy and safety of Wuling capsule, a single herbal formula, in Chinese subjects with insomnia: A multicenter, randomized, double-blind, placebo-controlled trial

Bent, 2006, Valerian for sleep: a systematic review and meta-analysis, American Journal of Medicine, 119, 1005, 10.1016/j.amjmed.2006.02.026 Chen, 2007, Clinical observation on Wuling capsule in treating 60 cases insomnia, Zhejiang Journal of Integrated Traditional Chinese and Western Medicine, 17, 442 Chen, 2012, Determination of multiple constituents in Wuling capsules by HPLC simultaneously, China Journal of Chinese Materials Medica, 37, 218 Charles, 2009, Insomnia, Australian Family Physician, 38, 283 Chow, 2003 De, 2004, International committee of medical journal editors. Clinical trial registration: a statement from the international committee of medical journal editors, Lancet, 364, 911, 10.1016/S0140-6736(04)17034-7 Doghramji, 2006, The epidemiology and diagnosis of insomnia, American Journal of Managed Care, 12, S214 Edinger, 2004, American Academy of Sleep Medicine Work Group. Derivation of research diagnostic criteria for insomnia: report of an American Academy of Sleep Medicine Work Group, Sleep, 27, 1567, 10.1093/sleep/27.8.1567 Fernández-San-Martín, 2010, Effectiveness of Valerian on insomnia: a meta-analysis of randomized placebo-controlled trials, Sleep Medicine, 11, 505, 10.1016/j.sleep.2009.12.009 Gyllenhaal, 2000, Efficacy and safety of herbal stimulants and sedatives in sleep disorders, Sleep Medicine Reviews, 4, 229, 10.1053/smrv.1999.0093 Han, 2007, Clinical applications and adverse reactions of Wuling capsule (review), China Pharmacy, 18, 1184 He, 2010, Determination of 14 kinds of amino acids in Wuling capsule by HPLC-FLD, Chinese Traditional Patent Medicine, 32, 1358 Kessler, 2005, Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication, Archives of General Psychiatry, 62, 617, 10.1001/archpsyc.62.6.617 Lader, 2011, Benzodiazepines revisited-will we ever learn?, Addiction, 106, 2086, 10.1111/j.1360-0443.2011.03563.x Li, 2011, Effects of Wuling capsule on hippocampal dependent cognitive changes in post-stroke depression rats, International Journal of Pharmacology, 7, 50, 10.3923/ijp.2011.50.57 Li, 2006, Wuling capsule in treatment of insomnia of aged patients, Chinese Journal of New Drugs and Clinical Remedies, 25, 289 Lu, 2011, HPLC specific chromatogram of chemical constituents of Wuling capsules, Chinese Journal of Pharmaceutical Analysis, 31, 764 Ma, 2003, Wuling capsule in treatment of 42 cases insomnia due to disharmony between the heart and kidney, Chinese Journal of Traditional Medical Science and Technology, 10, 304 Ma, 1999, Studies on the sedative and sleeping effects of Wuling mycelia and its pharmacological mechanism, Chinese Pharmaceutical Journal, 34, 374 Morgan, 2011, Insomnia: evidence-based approaches to assessment and management, Clinical Medicine, 11, 278, 10.7861/clinmedicine.11-3-278 No authors listed, 2005. National Institutes of Health State of the Science Conference Statement on Manifestations and Management of Chronic Insomnia in Adults, June 13–15, 2005. Sleep 28, 1049–1057. Ohayon, 1995, Insomnia and psychotropic drug consumption., Progress in Neuro-psychopharmacology & Biological Psychiatry, 19, 421, 10.1016/0278-5846(94)00023-B Pearson, 2006, Insomnia, trouble sleeping, and complementary and alternative medicine: analysis of the 2002 national health interview survey data, Archives of Internal Medicine, 166, 1775, 10.1001/archinte.166.16.1775 Sarris, 2011, A systematic review of insomnia and complementary medicine, Sleep Medicine Reviews, 15, 99, 10.1016/j.smrv.2010.04.001 Sarris, 2011, Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence, European Neuropsychopharmacology, 21, 841, 10.1016/j.euroneuro.2011.04.002 Taibi, 2007, A systematic review of valerian as a sleep aid: safe but not effective, Sleep Medicine Reviews, 11, 209, 10.1016/j.smrv.2007.03.002 Wang, 2010, Review on pharmacological effects and clinical application of Wuling shen, Global Traditional Chinese Medicine, 13, 150 Wang, 2009, Wuling capsule for climacteric patients with depression and anxiety state: a randomized, positive parallel controlled trial, Chinese Journal of Integrative Medicine, 7, 1042, 10.3736/jcim20091104 Yeh, 2011, Suan zao ren tang as an original treatment for sleep difficulty in climacteric women: a prospective clinical observation, Evidence Based Complementary and Alternative Medicine, 2011, 673813, 10.1155/2011/673813 Yin, 2011, Advance in clinical application of Wuling capsule, Chinese Journal of New Drugs, 20, 1530