The 2013 International Society for Heart and Lung Transplantation Guidelines for mechanical circulatory support: Executive summary

Kirklin, 2011, Third INTERMACS Annual Report: the evolution of destination therapy in the United States, J Heart Lung Transplant, 30, 115, 10.1016/j.healun.2010.12.001 Park, 2012, Outcomes in advanced heart failure patients with left ventricular assist devices for destination therapy, Circ Heart Fail, 5, 241, 10.1161/CIRCHEARTFAILURE.111.963991 Slaughter, 2009, Advanced heart failure treated with continuous-flow left ventricular assist device, N Engl J Med, 361, 2241, 10.1056/NEJMoa0909938 Kirklin, 2010, Second INTERMACS annual report: more than 1,000 primary left ventricular assist device implants, J Heart Lung Transplant, 29, 1, 10.1016/j.healun.2009.10.009 Stewart, 2011, Keeping left ventricular assist device acceleration on track, Circulation, 123, 1559, 10.1161/CIRCULATIONAHA.110.982512 Teuteberg, 2010, Strategies for LVAD therapy in INTERMACS: intent rate versus event rate [abstract], J Heart Lung Transplant, 29, S26, 10.1016/j.healun.2009.11.070 Stevenson, 2009, INTERMACS profiles of advanced heart failure: the current picture, J Heart Lung Transplant, 28, 535, 10.1016/j.healun.2009.02.015 Levy, 2006, The Seattle Heart Failure Model: prediction of survival in heart failure, Circulation, 113, 1424, 10.1161/CIRCULATIONAHA.105.584102 Goda, 2011, Selecting patients for heart transplantation: comparison of the Heart Failure Survival Score (HFSS) and the Seattle heart failure model (SHFM), J Heart Lung Transplant, 30, 1236, 10.1016/j.healun.2011.05.012 Levy, 2009, Can the Seattle heart failure model be used to risk-stratify heart failure patients for potential left ventricular assist device therapy?, J Heart Lung Transplant, 28, 231, 10.1016/j.healun.2008.12.015 Kalogeropoulos, 2009, Utility of the Seattle Heart Failure Model in patients with advanced heart failure, J Am Coll Cardiol, 53, 334, 10.1016/j.jacc.2008.10.023 Gorodeski, 2010, Application of the Seattle Heart Failure Model in ambulatory patients presented to an advanced heart failure therapeutics committee, Circ Heart Fail, 3, 706, 10.1161/CIRCHEARTFAILURE.110.944280 Pamboukian, 2012, Comparison of observed survival with assist device versus predicted survival without device using the Seattle heart failure model, ASAIO J, 58, 93, 10.1097/MAT.0b013e31824450f9 Aaronson, 1997, Development and prospective validation of a clinical index to predict survival in ambulatory patients referred for cardiac transplant evaluation, Circulation, 95, 2660, 10.1161/01.CIR.95.12.2660 Parikh, 2009, Usefulness of peak exercise oxygen consumption and the heart failure survival score to predict survival in patients>65 years of age with heart failure, Am J Cardiol, 103, 998, 10.1016/j.amjcard.2008.12.010 Goda, 2010, Comparison across races of peak oxygen consumption and heart failure survival score for selection for cardiac transplantation, Am J Cardiol, 105, 1439, 10.1016/j.amjcard.2009.12.067 Green, 2007, Comparison of peak exercise oxygen consumption and the Heart Failure Survival Score for predicting prognosis in women versus men, Am J Cardiol, 99, 399, 10.1016/j.amjcard.2006.08.046 Lund, 2005, Validation of peak exercise oxygen consumption and the Heart Failure Survival Score for serial risk stratification in advanced heart failure, Am J Cardiol, 95, 734, 10.1016/j.amjcard.2004.11.024 Mancini, 1991, Value of peak exercise oxygen consumption for optimal timing of cardiac transplantation in ambulatory patients with heart failure, Circulation, 83, 778, 10.1161/01.CIR.83.3.778 Mehra, 2006, Listing criteria for heart transplantation: International Society for Heart and Lung Transplantation guidelines for the care of cardiac transplant candidates—2006, J Heart Lung Transplant, 25, 1024, 10.1016/j.healun.2006.06.008 Stevenson, 2004, Left ventricular assist device as destination for patients undergoing intravenous inotropic therapy: a subset analysis from REMATCH (Randomized Evaluation of Mechanical Assistance in Treatment of Chronic Heart Failure), Circulation, 110, 975, 10.1161/01.CIR.0000139862.48167.23 Hershberger, 2003, Care processes and clinical outcomes of continuous outpatient support with inotropes (COSI) in patients with refractory endstage heart failure, J Card Fail, 9, 180, 10.1054/jcaf.2003.24 Krell, 1986, Intermittent, ambulatory dobutamine infusions in patients with severe congestive heart failure, Am Heart J, 112, 787, 10.1016/0002-8703(86)90475-8 Rao, 2003, Revised screening scale to predict survival after insertion of a left ventricular assist device, J Thorac Cardiovasc Surg, 125, 855, 10.1067/mtc.2003.111 Lietz, 2007, Outcomes of left ventricular assist device implantation as destination therapy in the post-REMATCH era: implications for patient selection, Circulation, 116, 497, 10.1161/CIRCULATIONAHA.107.691972 Knaus, 1985, APACHE II: a severity of disease classification system, Crit Care Med, 13, 818, 10.1097/00003246-198510000-00009 Schaffer, 2009, Evaluation of risk indices in continuous-flow left ventricular assist device patients, Ann Thorac Surg, 88, 1889, 10.1016/j.athoracsur.2009.08.011 Teuteberg, 2011, Application of the destination therapy risk score to HeartMate II clinical trial data [abstract] [manuscript in press, JACC], J Heart Lung Transplant, 30, S31, 10.1016/j.healun.2011.01.078 Boyle, 2011, Clinical outcomes for continuous-flow left ventricular assist device patients stratified by pre-operative INTERMACS classification, J Heart Lung Transplant, 30, 402, 10.1016/j.healun.2010.10.016 Cowger, 2011, The HeartMate II risk score: Predicting survival in candidates for left ventricular assist device support [abstract], J Heart Lung Transplant, 30, S31, 10.1016/j.healun.2011.01.077 Pagani, 2009, Extended mechanical circulatory support with a continuous-flow rotary left ventricular assist device, J Am Coll Cardiol, 54, 312, 10.1016/j.jacc.2009.03.055 Strueber, 2011, Multicenter evaluation of an intrapericardial left ventricular assist system, J Am Coll Cardiol, 57, 1375, 10.1016/j.jacc.2010.10.040 Johnsson, 1991, Cardiopulmonary perfusion and cerebral blood flow in bilateral carotid artery disease, Ann Thorac Surg, 51, 579, 10.1016/0003-4975(91)90315-H Selim, 2008, Angioplasty and stenting of asymptomatic carotid stenosis before cardiac surgery: more study is needed, Arch Neurol, 65, 1672, 10.1001/archneurol.2008.501 Lazar, 1998, Coronary artery bypass grafting in patients with cerebrovascular disease, Ann Thorac Surg, 66, 968, 10.1016/S0003-4975(98)00687-0 Mikus, 2011, Reversibility of fixed pulmonary hypertension in left ventricular assist device support recipients, Eur J Cardiothorac Surg, 40, 971 Uriel, 2011, Fixed pulmonary hypertension and mechanical support: an unclear opportunity, J Heart Lung Transplant, 30, 600, 10.1016/j.healun.2010.12.006 Mikus, 2011, Left ventricular assist device or heart transplantation: impact of transpulmonary gradient and pulmonary vascular resistance on decision making, Eur J Cardiothorac Surg, 39, 310, 10.1016/j.ejcts.2010.05.031 Kato, 2012, Pre-operative and post-operative risk factors associated with neurologic complications in patients with advanced heart failure supported by a left ventricular assist device, J Heart Lung Transplant, 31, 1, 10.1016/j.healun.2011.08.014 Wadia, 2005, Pathophysiology of hepatic dysfunction and intrahepatic cholestasis in heart failure and after left ventricular assist device support, J Heart Lung Transplant, 24, 361, 10.1016/j.healun.2004.09.012 Levy, 2010, Heparin-induced thrombocytopenia and cardiac surgery, Curr Opin Anaesthesiol, 23, 74, 10.1097/ACO.0b013e328334dd2f Morel-Kopp, 2010, Whole blood impedance aggregometry detects heparin-induced thrombocytopenia antibodies, Thromb Res, 125, e234, 10.1016/j.thromres.2009.12.001 Warkentin, 2009, Heparin-induced thrombocytopenia in patients with ventricular assist devices: are new prevention strategies required?, Ann Thorac Surg, 87, 1633, 10.1016/j.athoracsur.2008.10.060 Zucker, 2010, Cardiac transplantation and/or mechanical circulatory support device placement using heparin anti-coagulation in the presence of acute heparin-induced thrombocytopenia, J Heart Lung Transplant, 29, 53, 10.1016/j.healun.2009.08.016 Butler, 2005, Diabetes and outcomes after left ventricular assist device placement, J Card Fail, 11, 510, 10.1016/j.cardfail.2005.05.003 Topkara, 2005, Effect of diabetes on short- and long-term outcomes after left ventricular assist device implantation, J Heart Lung Transplant, 24, 2048, 10.1016/j.healun.2005.06.021 Uriel, 2011, Improved diabetic control in advanced heart failure patients treated with left ventricular assist devices, Eur J Heart Fail, 13, 195, 10.1093/eurjhf/hfq204 Kolesar, 2010, Use of left ventricle assist device in a pregnant woman with acute aortic and coronary dissections, Interact Cardiovasc Thorac Surg, 11, 194, 10.1510/icvts.2010.238501 LaRue, 2011, Left ventricular assist device in pregnancy, Obstet Gynecol, 118, 426, 10.1097/AOG.0b013e31820fcdaf Oles, 2001, Emergency redo mitral valve replacement in a 27-year-old pregnant female with a clotted prosthetic mitral valve, preoperative fetal demise and postoperative ventricular assist device: a case report, Perfusion, 16, 159, 10.1177/026765910101600211 Sims, 2011, A successful pregnancy during mechanical circulatory device support, J Heart Lung Transplant, 30, 1065, 10.1016/j.healun.2011.06.001 Holman, 2009, Predictors of death and transplant in patients with a mechanical circulatory support device: a multi-institutional study, J Heart Lung Transplant, 28, 44, 10.1016/j.healun.2008.10.011 Adamson, 2011, Clinical strategies and outcomes in advanced heart failure patients older than 70 years of age receiving the HeartMate II left ventricular assist device: a community hospital experience, J Am Coll Cardiol, 57, 2487, 10.1016/j.jacc.2011.01.043 Cupples, 2006, J Heart Lung Transplant, 25, 716, 10.1016/j.healun.2006.02.005 Eshelman, 2009, LVAD destination therapy: applying what we know about psychiatric evaluation and management from cardiac failure and transplant, Heart Fail Rev, 14, 21, 10.1007/s10741-007-9075-5 Levenson, 1993, Psychosocial evaluation of organ transplant candidates. A comparative survey of process, criteria, and outcomes in heart, liver, and kidney transplantation, Psychosomatics, 34, 314, 10.1016/S0033-3182(93)71865-4 Olbrisch, 2002, Psychological assessment and care of organ transplant patients, J Consult Clin Psychol, 70, 771, 10.1037/0022-006X.70.3.771 Olbrisch, 1995, Psychosocial assessment of organ transplant candidates. Current status of methodological and philosophical issues, Psychosomatics, 36, 236, 10.1016/S0033-3182(95)71662-0 De Geest, 1998, Late acute rejection and subclinical noncompliance with cyclosporine therapy in heart transplant recipients, J Heart Lung Transplant, 17, 854 De Geest, 2000, Clinical risk associated with appointment noncompliance in heart transplant recipients, Prog Transplant, 10, 162, 10.7182/prtr.10.3.mtx734810867w680 De Geest, 2005, Adherence to the therapeutic regimen in heart, lung, and heart-lung transplant recipients, J Cardiovasc Nurs, 20, S88, 10.1097/00005082-200509001-00010 Dew, 1996, Medical compliance and its predictors in the first year after heart transplantation, J Heart Lung Transplant, 15, 631 Nagele, 1997, Smoking after heart transplantation: an underestimated hazard?, Eur J Cardiothorac Surg, 12, 70, 10.1016/S1010-7940(97)00156-5 Dew, 2008, Meta-analysis of risk for relapse to substance use after transplantation of the liver or other solid organs, Liver Transpl, 14, 159, 10.1002/lt.21278 Kaan, 2010, Emotional experiences of caregivers of patients with a ventricular assist device, Prog Transplant, 20, 142, 10.7182/prtr.20.2.h26u0x93puu386w6 Marcuccilli, 2011, From insiders’ perspectives: adjusting to caregiving for patients with left ventricular assist devices, Prog Transplant, 21, 137, 10.7182/prtr.21.2.dq53164u1464u683 Bunzel, 2005, Posttraumatic stress disorder after implantation of a mechanical assist device followed by heart transplantation: evaluation of patients and partners, Transplant Proc, 37, 1365, 10.1016/j.transproceed.2004.12.248 Bunzel, 2007, Mechanical circulatory support as a bridge to heart transplantation: what remains? Long-term emotional sequelae in patients and spouses, J Heart Lung Transplant, 26, 384, 10.1016/j.healun.2007.01.025 Raymond, 2010, Obesity and left ventricular assist device driveline exit site infection, ASAIO J, 56, 57, 10.1097/MAT.0b013e3181c879b1 Zahr, 2011, Obese patients and mechanical circulatory support: weight loss, adverse events, and outcomes, Ann Thorac Surg, 92, 1420, 10.1016/j.athoracsur.2011.05.085 Brewer, 2012, Extremes of body mass index do not impact mid-term survival after continuous-flow left ventricular assist device implantation, J Heart Lung Transplant, 31, 167, 10.1016/j.healun.2011.11.006 Dhesi, 2011, Left ventricular assist device as ‘bridge to weight loss’ prior to transplantation in obese patients with advanced heart failure, Ann Transplant, 16, 5 Thompson, 2011, Evaluation of the HeartMate II left ventricular assist device in obese heart failure patients: effects on weight loss, Ann Transplant, 16, 63, 10.12659/AOT.881867 Butler, 2012, Mechanical circulatory support for elderly heart failure patients, Heart Fail Rev, 17, 663, 10.1007/s10741-012-9298-y Rizzieri, 2008, Ethical challenges with the left ventricular assist device as a destination therapy, Philos Ethics Humanit Med, 3, 20, 10.1186/1747-5341-3-20 Hunt, 2009, J Am Coll Cardiol, 53, e1, 10.1016/j.jacc.2008.11.013 Brush, 2010, End-of-life decision making and implementation in recipients of a destination left ventricular assist device, J Heart Lung Transplant, 29, 1337, 10.1016/j.healun.2010.07.001 Sandner, 2009, Renal function and outcome after continuous flow left ventricular assist device implantation, Ann Thorac Surg, 87, 1072, 10.1016/j.athoracsur.2009.01.022 Butler, 2006, Relationship between renal function and left ventricular assist device use, Ann Thorac Surg, 81, 1745, 10.1016/j.athoracsur.2005.11.061 Topkara, 2006, Predictors and outcomes of continuous veno-venous hemodialysis use after implantation of a left ventricular assist device, J Heart Lung Transplant, 25, 404, 10.1016/j.healun.2005.11.457 Ootaki, 2008, Reduced pulsatility induces periarteritis in kidney: role of the local renin-angiotensin system, J Thorac Cardiovasc Surg, 136, 150, 10.1016/j.jtcvs.2007.12.023 Sandner, 2008, Renal function after implantation of continuous versus pulsatile flow left ventricular assist devices, J Heart Lung Transplant, 27, 469, 10.1016/j.healun.2007.12.012 Radovancevic, 2007, End-organ function in patients on long-term circulatory support with continuous- or pulsatile-flow assist devices, J Heart Lung Transplant, 26, 815, 10.1016/j.healun.2007.05.012 Letsou, 2003, Continuous axial-flow left ventricular assist device (Jarvik 2000) maintains kidney and liver perfusion for up to 6 months, Ann Thorac Surg, 76, 1167, 10.1016/S0003-4975(03)00724-0 Russell, 2009, Renal and hepatic function improve in advanced heart failure patients during continuous-flow support with the HeartMate II left ventricular assist device, Circulation, 120, 2352, 10.1161/CIRCULATIONAHA.108.814863 Miller, 2007, Use of a continuous-flow device in patients awaiting heart transplantation, N Engl J Med, 357, 885, 10.1056/NEJMoa067758 Slaughter, 2010, Clinical management of continuous-flow left ventricular assist devices in advanced heart failure, J Heart Lung Transplant, 29, S1, 10.1016/j.healun.2010.01.011 Singh, 2011, Impact of renal function before mechanical circulatory support on posttransplant renal outcomes, Ann Thorac Surg, 91, 1348, 10.1016/j.athoracsur.2010.10.036 Holdy, 2005, Nutrition assessment and management of left ventricular assist device patients, J Heart Lung Transplant, 24, 1690, 10.1016/j.healun.2004.11.047 Liszkowski, 2010, INTERMACS profiles of nutrition and organ function in relation to outcomes [abstract], J Heart Lung Transplant, 29, S27, 10.1016/j.healun.2009.11.071 Nunez, 2011, Low lymphocyte count and cardiovascular diseases, Curr Med Chem, 18, 3226, 10.2174/092986711796391633 Vardeny, 2010, Decreased T-cell responses to influenza vaccination in patients with heart failure, Pharmacotherapy, 30, 10, 10.1592/phco.30.1.10 Betjes, 2011, Premature aging of circulating T cells in patients with end-stage renal disease, Kidney Int, 80, 208, 10.1038/ki.2011.110 Stofkova, 2009, Leptin and adiponectin: from energy and metabolic dysbalance to inflammation and autoimmunity, Endocr Regul, 43, 157 Acharya, 2012, What is the optimum antibiotic prophylaxis in patients undergoing implantation of a left ventricular assist device?, Interact Cardiovasc Thorac Surg, 14, 209, 10.1093/icvts/ivr054 Holman, 1999, Infection during circulatory support with ventricular assist devices, Ann Thorac Surg, 68, 711, 10.1016/S0003-4975(99)00529-9 Saito, 2009, Long-term medical control of inflow cuff infection in a patient with a left ventricular assist system, J Artif Organs, 12, 58, 10.1007/s10047-008-0444-1 Gelow, 2010, Clinical predictors of hepatic fibrosis in chronic advanced heart failure, Circ Heart Fail, 3, 59, 10.1161/CIRCHEARTFAILURE.109.872556 Matthews, 2010, Model for end-stage liver disease score predicts left ventricular assist device operative transfusion requirements, morbidity, and mortality, Circulation, 121, 214, 10.1161/CIRCULATIONAHA.108.838656 Concha, 2010, [Perioperative risk among patients with cirrhosis], Rev Med Chil, 138, 1165 Modi, 2010, Do patients with liver cirrhosis undergoing cardiac surgery have acceptable outcomes?, Interact Cardiovasc Thorac Surg, 11, 630, 10.1510/icvts.2010.241190 Frazier, 2001, Multicenter clinical evaluation of the HeartMate vented electric left ventricular assist system in patients awaiting heart transplantation, J Thorac Cardiovasc Surg, 122, 1186, 10.1067/mtc.2001.118274 Khan, 2005, Pre-operative pulmonary evaluation, J Ayub Med Coll Abbottabad, 17, 82 Wright, 2001, Assessment of a low-intensity cardiac rehabilitation programme using the six-minute walk test, Clin Rehabil, 15, 119, 10.1191/026921501671364449 Smetana, 1999, Preoperative pulmonary evaluation, N Engl J Med, 340, 937, 10.1056/NEJM199903253401207 Smetana, 2006, Preoperative pulmonary risk stratification for noncardiothoracic surgery: systematic review for the American College of Physicians, Ann Intern Med, 144, 581, 10.7326/0003-4819-144-8-200604180-00009 Miller, 2006, Candidate selection for long-term left ventricular assist device therapy for refractory heart failure, J Heart Lung Transplant, 25, 756, 10.1016/j.healun.2006.03.007 Miller, 2005, General considerations for lung function testing, Eur Respir J, 26, 153, 10.1183/09031936.05.00034505 Pellegrino, 2005, Interpretative strategies for lung function tests, Eur Respir J, 26, 948, 10.1183/09031936.05.00035205 Rady, 1999, Perioperative predictors of extubation failure and the effect on clinical outcome after cardiac surgery, Crit Care Med, 27, 340, 10.1097/00003246-199902000-00041 Samuels, 1998, Coronary artery bypass grafting in patients with COPD, Chest, 113, 878, 10.1378/chest.113.4.878 Dimick, 2004, Hospital costs associated with surgical complications: a report from the private-sector National Surgical Quality Improvement Program, J Am Coll Surg, 199, 531, 10.1016/j.jamcollsurg.2004.05.276 Bapoje, 2007, Preoperative evaluation of the patient with pulmonary disease, Chest, 132, 1637, 10.1378/chest.07-0347 Arozullah, 2000, Multifactorial risk index for predicting postoperative respiratory failure in men after major noncardiac surgery. The National Veterans Administration Surgical Quality Improvement Program, Ann Surg, 232, 242, 10.1097/00000658-200008000-00015 Canet, 2010, Prediction of postoperative pulmonary complications in a population-based surgical cohort, Anesthesiology, 113, 1338, 10.1097/ALN.0b013e3181fc6e0a Kroenke, 1993, Postoperative complications after thoracic and major abdominal surgery in patients with and without obstructive lung disease, Chest, 104, 1445, 10.1378/chest.104.5.1445 Culver, 2012, How should the lower limit of the normal range be defined?, Respir Care, 57, 136, 10.4187/respcare.01427 Feldman, 2008, Mechanisms of disease: detrimental adrenergic signaling in acute decompensated heart failure, Nat Clin Pract Cardiovasc Med, 5, 208, 10.1038/ncpcardio1127 Pagani, 1999, Extracorporeal life support to left ventricular assist device bridge to heart transplant: A strategy to optimize survival and resource utilization, Circulation, 100, II206, 10.1161/01.CIR.100.suppl_2.II-206 Copeland, 2004, Cardiac replacement with a total artificial heart as a bridge to transplantation, N Engl J Med, 351, 859, 10.1056/NEJMoa040186 Aziz, 2010, Initial experience with CentriMag extracorporal membrane oxygenation for support of critically ill patients with refractory cardiogenic shock, J Heart Lung Transplant, 29, 66, 10.1016/j.healun.2009.08.025 Bagai, 2011, Efficacy and safety of percutaneous life support during high-risk percutaneous coronary intervention, refractory cardiogenic shock and in-laboratory cardiopulmonary arrest, J Invasive Cardiol, 23, 141 Cleveland, 2011, Survival after biventricular assist device implantation: an analysis of the Interagency Registry for Mechanically Assisted Circulatory Support database, J Heart Lung Transplant, 30, 862 Krabatsch, 2011, Mechanical circulatory support-results, developments and trends, J Cardiovasc Transl Res, 4, 332, 10.1007/s12265-011-9268-0 Thiele, 2005, Randomized comparison of intra-aortic balloon support with a percutaneous left ventricular assist device in patients with revascularized acute myocardial infarction complicated by cardiogenic shock, Eur Heart J, 26, 1276, 10.1093/eurheartj/ehi161 Engstrom, 2011, The Impella 2.5 and 5.0 devices for ST-elevation myocardial infarction patients presenting with severe and profound cardiogenic shock: the Academic Medical Center intensive care unit experience, Crit Care Med, 39, 2072, 10.1097/CCM.0b013e31821e89b5 Koeckert, 2011, 2.5 for left ventricular unloading during venoarterial extracorporeal membrane oxygenation support, J Card Surg, 26, 666, 10.1111/j.1540-8191.2011.01338.x Meyns, 2003, Initial experiences with the Impella device in patients with cardiogenic shock—Impella support for cardiogenic shock, Thorac Cardiovasc Surg, 51, 312, 10.1055/s-2003-45422 Siegenthaler, 2004, The Impella Recover microaxial left ventricular assist device reduces mortality for postcardiotomy failure: a three-center experience, J Thorac Cardiovasc Surg, 127, 812, 10.1016/j.jtcvs.2003.09.055 Feldman, 2008, Management strategies for stage-D patients with acute heart failure, Clin Cardiol, 31, 297, 10.1002/clc.20251 Farrar, 1994, Ventricular interactions during mechanical circulatory support, Semin Thorac Cardiovasc Surg, 6, 163 Farrar, 1985, Right heart interaction with the mechanically assisted left heart, World J Surg, 9, 89, 10.1007/BF01656260 Dang, 2006, Right heart failure after left ventricular assist device implantation in patients with chronic congestive heart failure, J Heart Lung Transplant, 25, 1, 10.1016/j.healun.2005.07.008 Kavarana, 2002, Right ventricular dysfunction and organ failure in left ventricular assist device recipients: a continuing problem, Ann Thorac Surg, 73, 745, 10.1016/S0003-4975(01)03406-3 Ochiai, 2002, Predictors of severe right ventricular failure after implantable left ventricular assist device insertion: analysis of 245 patients, Circulation, 106, I198, 10.1161/01.cir.0000032906.33237.1c Fitzpatrick, 2009, Early planned institution of biventricular mechanical circulatory support results in improved outcomes compared with delayed conversion of a left ventricular assist device to a biventricular assist device, J Thorac Cardiovasc Surg, 137, 971, 10.1016/j.jtcvs.2008.09.021 Tsukui, 2005, Biventricular assist device utilization for patients with morbid congestive heart failure: a justifiable strategy, Circulation, 112, I65, 10.1161/CIRCULATIONAHA.104.524934 Kukucka, 2011, Right-to-left ventricular end-diastolic diameter ratio and prediction of right ventricular failure with continuous-flow left ventricular assist devices, J Heart Lung Transplant, 30, 64, 10.1016/j.healun.2010.09.006 Matthews, 2008, The right ventricular failure risk score a pre-operative tool for assessing the risk of right ventricular failure in left ventricular assist device candidates, J Am Coll Cardiol, 51, 2163, 10.1016/j.jacc.2008.03.009 Furukawa, 2005, Right ventricular failure after left ventricular assist device implantation: the need for an implantable right ventricular assist device, Artif Organs, 29, 369, 10.1111/j.1525-1594.2005.29063.x Fitzpatrick, 2008, Risk score derived from pre-operative data analysis predicts the need for biventricular mechanical circulatory support, J Heart Lung Transplant, 27, 1286, 10.1016/j.healun.2008.09.006 Kormos, 2010, Right ventricular failure in patients with the HeartMate II continuous-flow left ventricular assist device: incidence, risk factors, and effect on outcomes, J Thorac Cardiovasc Surg, 139, 1316, 10.1016/j.jtcvs.2009.11.020 Chumnanvej, 2007, Perioperative echocardiographic examination for ventricular assist device implantation, Anesth Analg, 105, 583, 10.1213/01.ane.0000278088.22952.82 Osculati, 2010, Left-to-right systolic ventricular interaction in patients undergoing biventricular stimulation for dilated cardiomyopathy, J Appl Physiol, 109, 418, 10.1152/japplphysiol.00770.2009 Mau, 2009, Chronic septal infarction confers right ventricular protection during mechanical left ventricular unloading, J Thorac Cardiovasc Surg, 138, 172, 10.1016/j.jtcvs.2009.03.012 Smith, 2006, The role of vasopressin in cardiorespiratory arrest and pulmonary hypertension, QJM, 99, 127, 10.1093/qjmed/hcl009 Ootaki, 2005, Phasic coronary blood flow pattern during a continuous flow left ventricular assist support, Eur J Cardiothorac Surg, 28, 711, 10.1016/j.ejcts.2005.08.008 Tuzun, 2004, Myocardial hemodynamics, physiology, and perfusion with an axial flow left ventricular assist device in the calf, ASAIO J, 50, 47, 10.1097/01.MAT.0000104819.23235.2F Voitl, 2009, Coronary hemodynamics and myocardial oxygen consumption during support with rotary blood pumps, Artif Organs, 33, 77, 10.1111/j.1525-1594.2008.00677.x Letsou, 2006, Myocardial perfusion as assessed by positron emission tomography during long-term mechanical circulatory support, Congest Heart Fail, 12, 69, 10.1111/j.1527-5299.2006.04686.x Xydas, 2005, Reduced myocardial blood flow during left ventricular assist device support: a possible cause of premature bypass graft closure, J Heart Lung Transplant, 24, 1976, 10.1016/j.healun.2005.03.003 Forrester, 2006, Saphenous vein graft flow during left ventricular assistance with an axial-flow pump, Tex Heart Inst J, 33, 222 Sommer, 2010, Heartmate II implantation with right coronary bypass grafting in ischemic cardiomyopathy with “fixed” pulmonary hypertension: treatment strategy to protect right ventricular function, J Card Surg, 25, 116, 10.1111/j.1540-8191.2009.00821.x Potapov, 2001, Revascularization of the occluded right coronary artery during left ventricular assist device implantation, J Heart Lung Transplant, 20, 918, 10.1016/S1053-2498(01)00266-2 Schroeder, 2000, Intraoperative use of inhaled PGI(2) for acute pulmonary hypertension and right ventricular failure, Anesth Analg, 91, 291 Fattouch, 2006, Treatment of pulmonary hypertension in patients undergoing cardiac surgery with cardiopulmonary bypass: a randomized, prospective, double-blind study, J Cardiovasc Med (Hagerstown ), 7, 119, 10.2459/01.JCM.0000203850.97890.fe Riker, 2009, Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial, JAM, 301, 489, 10.1001/jama.2009.56 Andre, 2005, Hemodynamic management of patients in the first 24 hours after cardiac surgery, Crit Care Med, 33, 2082, 10.1097/01.CCM.0000178355.96817.81 El-Banayosy, 2001, Device and patient management in a bridge-to-transplant setting, Ann Thorac Surg, 71, S98, 10.1016/S0003-4975(00)02618-7 Boyle, 2009, Low thromboembolism and pump thrombosis with the HeartMate II left ventricular assist device: analysis of outpatient anti-coagulation, J Heart Lung Transplant, 28, 881, 10.1016/j.healun.2009.05.018 John, 2008, Low thromboembolic risk for patients with the Heartmate II left ventricular assist device, J Thorac Cardiovasc Surg, 136, 1318, 10.1016/j.jtcvs.2007.12.077 Morshuis, 2009, European experience of DuraHeart magnetically levitated centrifugal left ventricular assist system, Eur J Cardiothorac Surg, 35, 1020, 10.1016/j.ejcts.2008.12.033 Slaughter, 2010, Post-operative heparin may not be required for transitioning patients with a HeartMate II left ventricular assist system to long-term warfarin therapy, J Heart Lung Transplant, 29, 616, 10.1016/j.healun.2010.02.003 Hetzer, 2010, Long-term biventricular support with the heartware implantable continuous flow pump, J Heart Lung Transplant, 29, 822, 10.1016/j.healun.2010.02.012 Samuels, 2008, Argatroban as a primary or secondary postoperative anticoagulant in patients implanted with ventricular assist devices, Ann Thorac Surg, 85, 1651, 10.1016/j.athoracsur.2008.01.100 Schenk, 2006, Triple bridge-to-transplant in a case of giant cell myocarditis complicated by human leukocyte antigen sensitization and heparin-induced thrombocytopenia type II, Ann Thorac Surg, 81, 1107, 10.1016/j.athoracsur.2004.12.045 Schenk, 2006, Heparin-induced thrombocytopenia in patients receiving mechanical circulatory support, J Thorac Cardiovasc Surg, 131, 1373, 10.1016/j.jtcvs.2006.01.048 Brismar, 1985, Pulmonary densities during anesthesia with muscular relaxation—a proposal of atelectasis, Anesthesiology, 62, 422, 10.1097/00000542-198504000-00009 van Belle, 1992, Postoperative pulmonary function abnormalities after coronary artery bypass surgery, Respir Med, 86, 195, 10.1016/S0954-6111(06)80054-5 Pinsky, 2005, Cardiovascular issues in respiratory care, Chest, 128, 592S, 10.1378/chest.128.5_suppl_2.592S Raikhelkar, 2007, Mechanical ventilation for cardiac support, Crit Care Clin, 23, 291, 10.1016/j.ccc.2006.12.004 Tedford, 2008, PDE5A inhibitor treatment of persistent pulmonary hypertension after mechanical circulatory support, Circ Heart Fail, 1, 213, 10.1161/CIRCHEARTFAILURE.108.796789 Matamis, 2012, Inhaled NO and sildenafil combination in cardiac surgery patients with out-of-proportion pulmonary hypertension: acute effects on postoperative gas exchange and hemodynamics, Circ Heart Fail, 5, 47, 10.1161/CIRCHEARTFAILURE.111.963314 Hatano, 2011, Less frequent opening of the aortic valve and a continuous flow pump are risk factors for postoperative onset of aortic insufficiency in patients with a left ventricular assist device, Circ J, 75, 1147, 10.1253/circj.CJ-10-1106 Toda, 2011, Late aortic insufficiency related to poor prognosis during left ventricular assist device support, Ann Thorac Surg, 92, 929, 10.1016/j.athoracsur.2011.04.115 Mudd, 2008, Fusion of aortic valve commissures in patients supported by a continuous axial flow left ventricular assist device, J Heart Lung Transplant, 27, 1269, 10.1016/j.healun.2008.05.029 International Society for Heart and Lung Transplantation. A 2010 working formulation for the standardization of definitions of infections in patients using ventricular assist devices (VADs). http://www.ishlt.org/contentdocument/VAD.pdf. 2010. Gordon, 2006, Ventricular assist device-related infections, Lancet Infect Dis, 6, 426, 10.1016/S1473-3099(06)70522-9 Kimball, 2008, Cellular immunity impaired among patients on left ventricular assist device for 6 months, Ann Thorac Surg, 85, 1656, 10.1016/j.athoracsur.2008.01.050 Shoham, 2009, Cardiac assist device infections, Curr Infect Dis Rep, 11, 268, 10.1007/s11908-009-0040-4 Gristina, 1988, Biomaterial-centered sepsis and the total artificial heart. Microbial adhesion vs tissue integration, JAM, 259, 870, 10.1001/jama.1988.03720060038027 Padera, 2006, Infection in ventricular assist devices: the role of biofilm, Cardiovasc Pathol, 15, 264, 10.1016/j.carpath.2006.04.008 Gordon, 2001, Nosocomial bloodstream infections in patients with implantable left ventricular assist devices, Ann Thorac Surg, 72, 725, 10.1016/S0003-4975(01)02888-0 Hanna, 2003, Antibiotic-impregnated catheters associated with significant decrease in nosocomial and multidrug-resistant bacteremias in critically ill patients, Chest, 124, 1030, 10.1378/chest.124.3.1030 Mermel, 2009, Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America, Clin Infect Dis, 49, 1, 10.1086/599376 O’Grady, 2002, Guidelines for the prevention of intravascular catheter-related infections, Infect Control Hosp Epidemiol, 23, 759, 10.1086/502007 Mangram, 1999, Guideline for prevention of surgical site infection, 1999. Hospital Infection Control Practices Advisory Committee, Infect Control Hosp Epidemiol, 20, 250, 10.1086/501620 Holman, 2003, Infection in ventricular assist devices: prevention and treatment, Ann Thorac Surg, 75, S48, 10.1016/S0003-4975(03)00479-X Darouiche, 2010, Chlorhexidine-alcohol versus povidone-iodine for surgical-site antisepsis, N Engl J Med, 362, 18, 10.1056/NEJMoa0810988 Edwards, 2006, The Society of Thoracic Surgeons Practice Guideline Series: antibiotic prophylaxis in cardiac surgery, part I: duration, Ann Thorac Surg, 81, 397, 10.1016/j.athoracsur.2005.06.034 Harbarth, 2000, Prolonged antibiotic prophylaxis after cardiovascular surgery and its effect on surgical site infections and antimicrobial resistance, Circulation, 101, 2916, 10.1161/01.CIR.101.25.2916 Eyler, 2009, Vancomycin use during left ventricular assist device support, Infect Control Hosp Epidemiol, 30, 484, 10.1086/597231 Engelman, 2007, The Society of Thoracic Surgeons practice guideline series: antibiotic prophylaxis in cardiac surgery, part II: antibiotic choice, Ann Thorac Surg, 83, 1569, 10.1016/j.athoracsur.2006.09.046 Perl, 2003, Prevention of Staphylococcus aureus infections among surgical patients: beyond traditional perioperative prophylaxis, Surgery, 134, S10, 10.1016/S0039-6060(03)00391-X Rose, 2001, Long-term use of a left ventricular assist device for end-stage heart failure, N Engl J Med, 345, 1435, 10.1056/NEJMoa012175 Holman, 2004, Infection in permanent circulatory support: experience from the REMATCH trial, J Heart Lung Transplant, 23, 1359, 10.1016/j.healun.2003.09.025 Wilson, 2007, Circulation, 116, 1736, 10.1161/CIRCULATIONAHA.106.183095 Myers, 2000, Infectious complications associated with ventricular assist systems, ASAIO J, 46, S28, 10.1097/00002480-200011000-00034 Pasque, 2002, Surgical management of Novacor drive-line exit site infections, Ann Thorac Surg, 74, 1267, 10.1016/S0003-4975(02)03752-9 Zierer, 2007, Late-onset driveline infections: the Achilles’ heel of prolonged left ventricular assist device support, Ann Thorac Surg, 84, 515, 10.1016/j.athoracsur.2007.03.085 Chinn, 2005, Multicenter experience: prevention and management of left ventricular assist device infections, ASAIO J, 51, 461, 10.1097/01.mat.0000170620.65279.aa Garatti, 2007, Drive-line exit-site infection in a patient with axial-flow pump support: successful management using vacuum-assisted therapy, J Heart Lung Transplant, 26, 956, 10.1016/j.healun.2007.06.007 Hravnak, 1993, Management of chronic left ventricular assist device percutaneous lead insertion sites, J Heart Lung Transplant, 12, 856 Baudouin, 2003, Nutritional support in critical care, Clin Chest Med, 24, 633, 10.1016/S0272-5231(03)00101-1 Scurlock, 2009, Impact of new technologies on metabolic care in the intensive care unit, Curr Opin Clin Nutr Metab Care, 12, 196, 10.1097/MCO.0b013e328321cd8f Scurlock, 2008, Intensive metabolic support: evolution and revolution, Endocr Pract, 14, 1047, 10.4158/EP.14.8.1047 Khalid, 2010, Early enteral nutrition and outcomes of critically ill patients treated with vasopressors and mechanical ventilation, Am J Crit Care, 19, 261, 10.4037/ajcc2010197 Aslam, 2010, Risk factors and outcomes of fungal ventricular-assist device infections, Clin Infect Dis, 50, 664, 10.1086/650454 Bond, 2004, Nursing education and implications for left ventricular assist device destination therapy, Prog Cardiovasc Nurs, 19, 95, 10.1111/j.0889-7204.2004.02461.x Stahl, 2002, Ventricular assist devices: developing and maintaining a training and competency program, J Cardiovasc Nurs, 16, 34, 10.1097/00005082-200204000-00005 Millhaem, 2007, Identifying the educational needs of nursing staff: the role of the clinical nurse specialist in perinatal nursing, J Nurses Staff Dev, 23, 277, 10.1097/01.NND.0000300834.92277.9e Savage, 2010, Developing and maintaining competency with circulatory assist devices: how to meet the challenge, Prog Transplant, 20, 125, 10.7182/prtr.20.2.78683565805w7288 Andrus, 2003, Teaching documentation tool: building a successful discharge, Crit Care Nurse, 23, 39, 10.4037/ccn2003.23.2.39 Holmes, 2003, Outpatient management of long-term assist devices, Cardiol Clin, 21, 93, 10.1016/S0733-8651(02)00138-8 Murray, 2009, Multidisciplinary approach decreases length of stay and reduces cost for ventricular assist device therapy, Interact Cardiovasc Thorac Surg, 8, 84, 10.1510/icvts.2008.187377 Stahovich, 2007, The next treatment option: using ventricular assist devices for heart failure, Crit Care Nurs Q, 30, 337, 10.1097/01.CNQ.0000290367.54998.29 Moroney, 1997, Outpatient use of left ventricular assist devices: nursing, technical, and educational considerations, Am J Crit Care, 6, 355, 10.4037/ajcc1997.6.5.355 Slaughter, 2007, Home discharge experience with the Thoratec TLC-II portable driver, ASAIO J, 53, 132, 10.1097/MAT.0b013e31802c189e Dew, 1999, Quality of life outcomes in left ventricular assist system inpatients and outpatients, ASAIO J, 45, 218, 10.1097/00002480-199905000-00022 Grady, 2001, Improvement in quality of life outcomes 2 weeks after left ventricular assist device implantation, J Heart Lung Transplant, 20, 657, 10.1016/S1053-2498(01)00253-4 Grady, 2002, Predictors of quality of life at 1 month after implantation of a left ventricular assist device, Am J Crit Care, 11, 345, 10.4037/ajcc2002.11.4.345 National Association of Social Workers. Standards for Social Work Practice in Health Care Settings. http://www.naswdc.org/practice/standards/naswhealthcarestandards.pdf. 2012. Adams, 2012, Association of depression and survival in patients with chronic heart failure over 12 years, Psychosomatics, 53, 339, 10.1016/j.psym.2011.12.002 Jiang, 2008, Safety and efficacy of sertraline for depression in patients with CHF (SADHART-CHF): a randomized, double-blind, placebo-controlled trial of sertraline for major depression with congestive heart failure, Am Heart J, 156, 437, 10.1016/j.ahj.2008.05.003 O’Connor, 2010, Safety and efficacy of sertraline for depression in patients with heart failure: results of the SADHART-CHF (Sertraline Against Depression and Heart Disease in Chronic Heart Failure) trial, J Am Coll Cardiol, 56, 692, 10.1016/j.jacc.2010.03.068 McGrady, 2009, Effects of depression and anxiety on adherence to cardiac rehabilitation, J Cardiopulm Rehabil Prev, 29, 358, 10.1097/HCR.0b013e3181be7a8f Humphrey, 1997, Exercise physiology in patients with left ventricular assist devices, J Cardiopulm Rehabil, 17, 73, 10.1097/00008483-199703000-00001 Goodlin, 2004, Consensus statement: palliative and supportive care in advanced heart failure, J Card Fail, 10, 200, 10.1016/j.cardfail.2003.09.006 Bramstedt, 2001, When withdrawal of life-sustaining care does more than allow death to take its course: the dilemma of left ventricular assist devices, J Heart Lung Transplant, 20, 544, 10.1016/S1053-2498(01)00235-2 Bramstedt, 2005, When death is the outcome of informed refusal: dilemma of rejecting ventricular assist device therapy, J Heart Lung Transplant, 24, 229, 10.1016/j.healun.2003.10.022 Wiegand, 2007, Withdrawal of cardiac medications and devices, AACN Adv Crit Care, 18, 415, 10.1097/01.AACN.0000298634.45653.81 Grady, 2003, Change in quality of life from before to after discharge following left ventricular assist device implantation, J Heart Lung Transplant, 22, 322, 10.1016/S1053-2498(02)00668-X Wilson, 2009, Ventricular assist devices: the challenges of outpatient management, J Am Coll Cardiol, 54, 1647, 10.1016/j.jacc.2009.06.035 Genovese, 2010, Early adverse events as predictors of 1-year mortality during mechanical circulatory support, J Heart Lung Transplant, 29, 981, 10.1016/j.healun.2010.04.014 Mehra, 2003, Allosensitization in heart transplantation: implications and management strategies, Curr Opin Cardiol, 18, 153, 10.1097/00001573-200303000-00015 Meyer, 2010, Acquired von Willebrand syndrome in patients with an axial flow left ventricular assist device, Circ Heart Fail, 3, 675, 10.1161/CIRCHEARTFAILURE.109.877597 Klovaite, 2009, Severely impaired von Willebrand factor-dependent platelet aggregation in patients with a continuous-flow left ventricular assist device (HeartMate II), J Am Coll Cardiol, 53, 2162, 10.1016/j.jacc.2009.02.048 Crow, 2009, Gastrointestinal bleeding rates in recipients of nonpulsatile and pulsatile left ventricular assist devices, J Thorac Cardiovasc Surg, 137, 208, 10.1016/j.jtcvs.2008.07.032 Crow, 2010, Acquired von Willebrand syndrome in continuous-flow ventricular assist device recipients, Ann Thorac Surg, 90, 1263, 10.1016/j.athoracsur.2010.04.099 Demirozu, 2011, Arteriovenous malformation and gastrointestinal bleeding in patients with the HeartMate II left ventricular assist device, J Heart Lung Transplant, 30, 849 Genovese, 2009, Incidence and patterns of adverse event onset during the first 60 days after ventricular assist device implantation, Ann Thorac Surg, 88, 1162, 10.1016/j.athoracsur.2009.06.028 Nakajima, 2011, Pre- and post-operative risk factors associated with cerebrovascular accidents in patients supported by left ventricular assist device. -Single center’s experience in Japan-, Circ J, 75, 1138, 10.1253/circj.CJ-10-0986 Tsukui, 2007, Cerebrovascular accidents in patients with a ventricular assist device, J Thorac Cardiovasc Surg, 134, 114, 10.1016/j.jtcvs.2007.02.044 Motallebzadeh, 2007, Neurocognitive function and cerebral emboli: randomized study of on-pump versus off-pump coronary artery bypass surgery, Ann Thorac Surg, 83, 475, 10.1016/j.athoracsur.2006.09.024 van Dijk, 2000, Neurocognitive dysfunction after coronary artery bypass surgery: a systematic review, J Thorac Cardiovasc Surg, 120, 632, 10.1067/mtc.2000.108901 Petrucci, 2012, Neurocognitive function in destination therapy patients receiving continuous-flow vs pulsatile-flow left ventricular assist device support, J Heart Lung Transplant, 31, 27, 10.1016/j.healun.2011.10.012 Hannan, 2011, Working formulation for the standardization of definitions of infections in patients using ventricular assist devices, J Heart Lung Transplant, 30, 375, 10.1016/j.healun.2011.01.717 Bedi, 2007, Ventricular arrhythmias during left ventricular assist device support, Am J Cardiol, 99, 1151, 10.1016/j.amjcard.2006.11.051 Cesario, 2011, Ventricular tachycardia in the era of ventricular assist devices, J Cardiovasc Electrophysiol, 22, 359, 10.1111/j.1540-8167.2010.01911.x Refaat, 2008, Ventricular arrhythmias after left ventricular assist device implantation, Pacing Clin Electrophysiol, 31, 1246, 10.1111/j.1540-8159.2008.01173.x Ziv, 2005, Effects of left ventricular assist device therapy on ventricular arrhythmias, J Am Coll Cardiol, 45, 1428, 10.1016/j.jacc.2005.01.035 Andersen, 2009, Incidence of ventricular arrhythmias in patients on long-term support with a continuous-flow assist device (HeartMate II), J Heart Lung Transplant, 28, 733, 10.1016/j.healun.2009.03.011 Martin, 2006, Improved durability of the HeartMate XVE left ventricular assist device provides safe mechanical support up to 1 year but is associated with high risk of device failure in the second year, J Heart Lung Transplant, 25, 384, 10.1016/j.healun.2005.11.437 Starling, 2011, J Am Coll Cardiol, 57, 1890, 10.1016/j.jacc.2010.10.062 John, 2011, Lessons learned from experience with over 100 consecutive HeartMate II left ventricular assist devices, Ann Thorac Surg, 92, 1593, 10.1016/j.athoracsur.2011.06.081 Cadeiras, 2011, Use of a vascular plug to percutaneously occlude the outflow conduit of a dysfunctional left ventricular assist device, J Heart Lung Transplant, 30, 733, 10.1016/j.healun.2011.01.723 Chrysant, 2010, Successful percutaneous management of acute left ventricular assist device stoppage, ASAIO J, 56, 483, 10.1097/MAT.0b013e3181ed937f Eckhauser, 2006, Management of general surgical problems in patients with left ventricular assist devices, Am Surg, 72, 158, 10.1177/000313480607200213 Garatti, 2009, Noncardiac surgical procedures in patient supported with long-term implantable left ventricular assist device, Am J Surg, 197, 710, 10.1016/j.amjsurg.2008.05.009 Schmid, 2001, Noncardiac surgery in patients with left ventricular assist devices, Surgery, 129, 440, 10.1016/S0039-6060(01)87310-4 Stehlik, 2009, Outcome of noncardiac surgery in patients with ventricular assist devices, Am J Cardiol, 103, 709, 10.1016/j.amjcard.2008.11.021 Votapka, 1994, Noncardiac operations in patients supported with mechanical circulatory support devices, J Am Coll Surg, 179, 318 Goldstein, 1995, Noncardiac surgery in long-term implantable left ventricular assist-device recipients, Ann Surg, 222, 203, 10.1097/00000658-199508000-00013 Stone, 2002, The anesthetic considerations in patients with ventricular assist devices presenting for noncardiac surgery: a review of eight cases, Anesth Analg, 95, 42, 10.1097/00000539-200207000-00007 Chestovich, 2011, Surgical procedures for patients receiving mechanical cardiac support, Am Surg, 77, 1314, 10.1177/000313481107701008 Mountis, 2009, Management of left ventricular assist devices after surgery: bridge, destination, and recovery, Curr Opin Cardiol, 24, 252, 10.1097/HCO.0b013e32832c7c09 Thoratec Corporation, 2011 Van de Bussche, 2010, Regionalized approach to emergency medical services training for the care of patients with mechanical assist devices, Prog Transplant, 20, 129, 10.7182/prtr.20.2.y546mq78836402v9 Disease specific care certification workbook. Oakbrook Terrace, IL: Joint Commission Resources, Inc., 2012. Pamboukian, 2011, Improvement in 2-year survival for ventricular assist device patients after implementation of an intensive surveillance protocol, J Heart Lung Transplant, 30, 879 Simon, 2010, Left ventricular remodeling and myocardial recovery on mechanical circulatory support, J Card Fail, 16, 99, 10.1016/j.cardfail.2009.10.018 Dandel, 2008, Prediction of cardiac stability after weaning from left ventricular assist devices in patients with idiopathic dilated cardiomyopathy, Circulation, 118, S94, 10.1161/CIRCULATIONAHA.107.755983 Hetzer, 2001, Bridging-to-recovery, Ann Thorac Surg, 71, S109, 10.1016/S0003-4975(00)02638-2 Mancini, 1998, Low incidence of myocardial recovery after left ventricular assist device implantation in patients with chronic heart failure, Circulation, 98, 2383, 10.1161/01.CIR.98.22.2383 Khan, 2003, Dobutamine stress echocardiography predicts myocardial improvement in patients supported by left ventricular assist devices (LVADs): hemodynamic and histologic evidence of improvement before LVAD explantation, J Heart Lung Transplant, 22, 137, 10.1016/S1053-2498(02)00485-0 Kirkpatrick, 2010, Left ventricular assist devices and other devices for end-stage heart failure: utility of echocardiography, Curr Cardiol Rep, 12, 257, 10.1007/s11886-010-0102-0 Catena, 2005, Left ventricular support by axial flow pump: the echocardiographic approach to device malfunction, J Am Soc Echocardiogr, 18, 1422, 10.1016/j.echo.2005.04.011 Scalia, 2000, Clinical utility of echocardiography in the management of implantable ventricular assist devices, J Am Soc Echocardiogr, 13, 754, 10.1067/mje.2000.105009 Baddour, 2003, Nonvalvular cardiovascular device-related infections, Circulation, 108, 2015, 10.1161/01.CIR.0000093201.57771.47 Pak, 2010, Prevalence of de novo aortic insufficiency during long-term support with left ventricular assist devices, J Heart Lung Transplant, 29, 1172, 10.1016/j.healun.2010.05.018 Cowger, 2010, The development of aortic insufficiency in left ventricular assist device-supported patients, Circ Heart Fail, 3, 668, 10.1161/CIRCHEARTFAILURE.109.917765 Connelly, 2003, Acquired commissural fusion of aortic valves in patients with left ventricular assist devices, J Heart Lung Transplant, 22, 1291, 10.1016/S1053-2498(03)00028-7 Carr, 2010, CT of left ventricular assist devices, Radiographics, 30, 429, 10.1148/rg.302095734 Raman, 2010, Noninvasive assessment of left ventricular assist devices with cardiovascular computed tomography and impact on management, J Heart Lung Transplant, 29, 79, 10.1016/j.healun.2009.06.023 Acharya, 2011, Use of gated cardiac computed tomography angiography in the assessment of left ventricular assist device dysfunction, ASAIO J, 57, 32, 10.1097/MAT.0b013e3181fd3405 Mancini, 2000, Peak VO (2): a simple yet enduring standard, Circulation, 101, 1080, 10.1161/01.CIR.101.10.1080 de, 2001, Exercise performance in patients with end-stage heart failure after implantation of a left ventricular assist device and after heart transplantation: an outlook for permanent assisting?, J Am Coll Cardiol, 37, 1794, 10.1016/S0735-1097(01)01268-2 Haft, 2007, Hemodynamic and exercise performance with pulsatile and continuous-flow left ventricular assist devices, Circulation, 116, I8, 10.1161/CIRCULATIONAHA.106.677898 Jaski, 1999, Comparison of functional capacity in patients with end-stage heart failure following implantation of a left ventricular assist device versus heart transplantation: results of the experience with left ventricular assist device with exercise trial, J Heart Lung Transplant, 18, 1031, 10.1016/S1053-2498(99)00071-6 Matthews, 2005, Maximal oxygen uptake improvements with long term LVAD support [abstract], J Heart Lung Transplant, 24, S107, 10.1016/j.healun.2004.11.222 Maybaum, 2007, Cardiac improvement during mechanical circulatory support: a prospective multicenter study of the LVAD Working Group, Circulation, 115, 2497, 10.1161/CIRCULATIONAHA.106.633180 Pulz, 2008, Incremental shuttle and six-minute walking tests in the assessment of functional capacity in chronic heart failure, Can J Cardiol, 24, 131, 10.1016/S0828-282X(08)70569-5 Morales, 1999, A shuttle walk test for assessment of functional capacity in chronic heart failure, Am Heart J, 138, 291, 10.1016/S0002-8703(99)70114-6 Pollentier, 2010, Examination of the six minute walk test to determine functional capacity in people with chronic heart failure: a systematic review, Cardiopulm Phys Ther J, 21, 13, 10.1097/01823246-201021010-00003 Spilker, 1996 O’Connor, 1989, An overview of randomized trials of rehabilitation with exercise after myocardial infarction, Circulation, 80, 234, 10.1161/01.CIR.80.2.234 Oldridge, 1988, Cardiac rehabilitation after myocardial infarction. Combined experience of randomized clinical trials, JAMA, 260, 945, 10.1001/jama.1988.03410070073031 Humphrey, 2001, Exercise, cardiovascular disease, and chronic heart failure, Arch Phys Med Rehabil, 82, S76, 10.1016/S0003-9993(01)80045-9 O’Connor, 2009, Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial, JAMA, 301, 1439, 10.1001/jama.2009.454 Jaski, 1997, Effects of exercise during long-term support with a left ventricular assist device. Results of the experience with left ventricular assist device with exercise (EVADE) pilot trial, Circulation, 95, 2401, 10.1161/01.CIR.95.10.2401 Nishimura, 1996, Exercise capacity recovers slowly but fully in patients with a left ventricular assist device, ASAIO J, 42, M568, 10.1097/00002480-199609000-00050 Salzberg, 2003, Left ventricular assist device as bridge to heart transplantation—lessons learned with the MicroMed DeBakey axial blood flow pump, Eur J Cardiothorac Surg, 24, 113, 10.1016/S1010-7940(03)00179-9 Morrone, 1996, Early progressive mobilization of patients with left ventricular assist devices is safe and optimizes recovery before heart transplantation, J Heart Lung Transplant, 15, 423 Perme, 2006, Early mobilization of LVAD recipients who require prolonged mechanical ventilation, Tex Heart Inst J, 33, 130 Mettauer, 2001, Exercise training with a heart device: a hemodynamic, metabolic, and hormonal study, Med Sci Sports Exerc, 33, 2, 10.1097/00005768-200101000-00002 Ueno, 2009, Cardiac rehabilitation and artificial heart devices, J Artif Organs, 12, 90, 10.1007/s10047-009-0461-8 Leon, 2005, Circulation, 111, 369, 10.1161/01.CIR.0000151788.08740.5C Cardiac rehabilitation programs, 1994, A statement for healthcare professionals from the American Heart Association, Circulation, 90, 1602, 10.1161/01.CIR.90.3.1602 Holman, 2009, INTERMACS: interval analysis of registry data, J Am Coll Surg, 208, 755, 10.1016/j.jamcollsurg.2008.11.016 Gasparyan, 2008, The role of aspirin in cardiovascular prevention: implications of aspirin resistance, J Am Coll Cardiol, 51, 1829, 10.1016/j.jacc.2007.11.080 Mason, 2005, Aspirin resistance and atherothrombotic disease, J Am Coll Cardiol, 46, 986, 10.1016/j.jacc.2004.08.070 Houel, 2004, Platelet activation and aggregation profile in prolonged external ventricular support, J Thorac Cardiovasc Surg, 128, 197, 10.1016/j.jtcvs.2003.11.059 Dewald, 2005, Platelet activation markers in patients with heart assist device, Artif Organs, 29, 292, 10.1111/j.1525-1594.2005.29050.x Radovancevic, 2009, Increased leukocyte-platelet interactions during circulatory support with left ventricular assist devices, ASAIO J, 55, 459, 10.1097/MAT.0b013e3181b235af Steinlechner, 2009, Platelet dysfunction in outpatients with left ventricular assist devices, Ann Thorac Surg, 87, 131, 10.1016/j.athoracsur.2008.10.027 Geisen, 2008, Non-surgical bleeding in patients with ventricular assist devices could be explained by acquired von Willebrand disease, Eur J Cardiothorac Surg, 33, 679, 10.1016/j.ejcts.2007.12.047 Warkentin, 1992, Aortic stenosis and bleeding gastrointestinal angiodysplasia: is acquired von Willebrand’s disease the link?, Lancet, 340, 35, 10.1016/0140-6736(92)92434-H Warkentin, 2003, Gastrointestinal bleeding, angiodysplasia, cardiovascular disease, and acquired von Willebrand syndrome, Transfus Med Rev, 17, 272, 10.1016/S0887-7963(03)00037-3 Letsou GV, Shah N, Gregoric ID, Myers TJ, Delgado R, Frazier OH. Gastrointestinal bleeding from arteriovenous malformations in patients supported by the Jarvik 2000 axial-flow left ventricular assist device. J Heart Lung Transplant 2005;24:105–9. Veyradier, 2001, Abnormal von Willebrand factor in bleeding angiodysplasias of the digestive tract, Gastroenterology, 120, 346, 10.1053/gast.2001.21204 Birks, 2006, Left ventricular assist device and drug therapy for the reversal of heart failure, N Engl J Med, 355, 1873, 10.1056/NEJMoa053063 Birks, 2011, Reversal of severe heart failure with a continuous-flow left ventricular assist device and pharmacological therapy: a prospective study, Circulation, 123, 381, 10.1161/CIRCULATIONAHA.109.933960 Kamdar, 2009, Effects of centrifugal, axial, and pulsatile left ventricular assist device support on end-organ function in heart failure patients, J Heart Lung Transplant, 28, 352, 10.1016/j.healun.2009.01.005 Thomas, 2008, Successful treatment of rotary pump thrombus with the glycoprotein IIb/IIIa inhibitor tirofiban, J Heart Lung Transplant, 27, 925, 10.1016/j.healun.2008.05.015 Kiernan, 2011, Management of HeartWare left ventricular assist device thrombosis using intracavitary thrombolytics, J Thorac Cardiovasc Surg, 142, 712, 10.1016/j.jtcvs.2010.11.022 Delgado, 2005, Direct thrombolytic therapy for intraventricular thrombosis in patients with the Jarvik 2000 left ventricular assist device, J Heart Lung Transplant, 24, 231, 10.1016/j.healun.2003.10.023 Rothenburger, 2002, Treatment of thrombus formation associated with the MicroMed DeBakey VAD using recombinant tissue plasminogen activator, Circulation, 106, I189, 10.1161/01.cir.0000032913.33237.f5 Lockard, 2009, Lack of improvement in prealbumin at two weeks predicts a poor outcome after mechanical circulatory support [abstract], J Heart Lung Transplant, 28, S66, 10.1016/j.healun.2008.11.011 Butler, 2005, Body mass index and outcomes after left ventricular assist device placement, Ann Thorac Surg, 79, 66, 10.1016/j.athoracsur.2004.06.047 Refaat, 2012, Survival benefit of implantable cardioverter-defibrillators in left ventricular assist device-supported heart failure patients, J Card Fail, 18, 140, 10.1016/j.cardfail.2011.10.020 Fuster, 2006, Europace, 8, 651, 10.1093/europace/eul097 Fuster, 2011, J Am Coll Cardiol, 57, e101, 10.1016/j.jacc.2010.09.013 Zipes, 2006, Circulation, 114, e385, 10.1161/CIRCULATIONAHA.106.178233 Jaarsma, 2009, Palliative care in heart failure: a position statement from the palliative care workshop of the Heart Failure Association of the European Society of Cardiology, Eur J Heart Fail, 11, 433, 10.1093/eurjhf/hfp041 Levenson, 1993, Psychiatric aspects of heart transplantation, Psychosomatics, 34, 114, 10.1016/S0033-3182(93)71901-5 Petrucci, 1999, Cardiac ventricular support. Considerations for psychiatry, Psychosomatics, 40, 298, 10.1016/S0033-3182(99)71222-3 Bunzel, 1994, Heart transplantation: are there psychosocial predictors for clinical success of surgery?, Thorac Cardiovasc Surg, 42, 103, 10.1055/s-2007-1016466 Kugler, 2011, Health-related quality of life and exercise tolerance in recipients of heart transplants and left ventricular assist devices: a prospective, comparative study, J Heart Lung Transplant, 30, 204, 10.1016/j.healun.2010.08.030 Kucukaksu, 2003, First Turkish experience with the MicroMed DeBakey VAD, Tex Heart Inst J, 30, 114 Laederach-Hofmann, 2000, Noncompliance in organ transplant recipients: a literature review, Gen Hosp Psychiatry, 22, 412, 10.1016/S0163-8343(00)00098-0 Bunzel, 2000, Solid organ transplantation: are there predictors for posttransplant noncompliance? A literature overview, Transplantation, 70, 711, 10.1097/00007890-200009150-00001 Baba, 2006, Psychiatric problems of heart transplant candidates with left ventricular assist devices, J Artif Organs, 9, 203, 10.1007/s10047-006-0353-0 Tigges-Limmer, 2010, Suicide after ventricular assist device implantation, J Heart Lung Transplant, 29, 692, 10.1016/j.healun.2009.12.005 Dew, 2001, Quality of life outcomes after heart transplantation in individuals bridged to transplant with ventricular assist devices, J Heart Lung Transplant, 20 Petrucci, 2009, Neurocognitive assessments in advanced heart failure patients receiving continuous-flow left ventricular assist devices, J Heart Lung Transplant, 28, 542, 10.1016/j.healun.2009.02.007 Marcus, 2009, Left ventricular assist devices: psychosocial challenges in the elderly, Ann Thorac Surg, 88, e48, 10.1016/j.athoracsur.2009.07.029 Dudzinski, 2006, Ethics guidelines for destination therapy, Ann Thorac Surg, 81, 1185, 10.1016/j.athoracsur.2005.11.002 Olbrisch, 1991, Psychosocial evaluation of heart transplant candidates: an international survey of process, criteria, and outcomes, J Heart Lung Transplant, 10, 948 Temel, 2010, Early palliative care for patients with metastatic non-small-cell lung cancer, N Engl J Med, 363, 733, 10.1056/NEJMoa1000678 Swetz, 2011, Palliative medicine consultation for preparedness planning in patients receiving left ventricular assist devices as destination therapy, Mayo Clin Proc, 86, 493, 10.4065/mcp.2010.0747