Epigenetic signatures of childhood abuse and neglect: Implications for psychiatric vulnerability

Baker-Andresen, 2013, Dynamic DNA methylation: a prime candidate for genomic metaplasticity and behavioral adaptation, Trends Neurosci., 36, 3, 10.1016/j.tins.2012.09.003

Belousov, 2013, Neuronal gap junctions: making and breaking connections during development and injury, Trends Neurosci., 36, 227, 10.1016/j.tins.2012.11.001

Bergman, 2013, DNA methylation dynamics in health and disease, Nat. Struct. Mol. Biol., 20, 274, 10.1038/nsmb.2518

Bernstein, 1998

Bigos, 2010, Genetic variation in CACNA1C affects brain circuitries related to mental illness, Arch. Gen. Psychiatry, 67, 939, 10.1001/archgenpsychiatry.2010.96

Carpenter, 2011, Effect of childhood physical abuse on cortisol stress response, Psychopharmacology, 214, 367, 10.1007/s00213-010-2007-4

Cecil, 2014, Double disadvantage: the influence of childhood maltreatment and community violence exposure on adolescent mental health, J. Child. Psychol. Psychiatry, 55, 839, 10.1111/jcpp.12213

Chen, 2013, Discovery of cross-reactive probes and polymorphic CpGs in the Illumina infinium HumanMethylation450 microarray, Epigenetics, 8, 203, 10.4161/epi.23470

Chiu, 1999, Cloning and characterization of T-cell lymphoma invasion and metastasis 2 TIAM2, a novel guanine nucleotide exchange factor related to TIAM1, Genomics, 61, 66, 10.1006/geno.1999.5936

Cicchetti, 2005, Child maltreatment, Annu. Rev. Clin. Psychol., 1, 409, 10.1146/annurev.clinpsy.1.102803.144029

Cross-Disorder Group of the Psychiatric Genomics Consortium, 2013, Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis, Lancet, 381, 1371, 10.1016/S0140-6736(12)62129-1

Danese, 2011, Biological embedding of stress through inflammation processes in childhood, Mol. Psychiatry, 16, 244, 10.1038/mp.2010.5

Danese, 2009, Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers, Arch. Pediatr. Adolesc. Med., 163, 1135, 10.1001/archpediatrics.2009.214

Day, 2013, DNA methylation regulates associative reward learning, Nat. Neurosci., 16, 1445, 10.1038/nn.3504

Deardorff, 2007, Mutations in cohesin complex members SMC3 and SMC1A cause a mild variant of cornelia de Lange syndrome with predominant mental retardation, Am. J. Hum. Genet., 80, 485, 10.1086/511888

Edwards, 2014

Epa, 2004, The p75 neurotrophin receptor enhances TrkA signalling by binding to Shc and augmenting its phosphorylation, J. Neurochem., 89, 344, 10.1111/j.1471-4159.2004.02344.x

Fenech, 2011, The effect of age, gender, diet and lifestyle on DNA damage measured using micronucleus frequency in human peripheral blood lymphocytes, Mutagenesis, 26, 43, 10.1093/mutage/geq050

Freeman, 2003, DNA from buccal swabs recruited by mail: evaluation of storage effects on long-term stability and suitability for multiplex polymerase chain reaction genotyping, Behav. Genet., 33, 67, 10.1023/A:1021055617738

Fuller-Thomson, 2010, The association between childhood physical abuse and heart disease in adulthood: findings from a representative community sample, Child. Abuse Negl., 34, 689, 10.1016/j.chiabu.2010.02.005

Gao, 2015, DNA methylation changes of whole blood cells in response to active smoking exposure in adults: a systematic review of DNA methylation studies, Clin. Epigenetics, 7, 1, 10.1186/s13148-015-0148-3

Hart, 2012, Neuroimaging of child abuse: a critical review, Front. Hum. Neurosci., 6, 52, 10.3389/fnhum.2012.00052

Jaenisch, 2003, Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals, Nat. Genet., 33, 245, 10.1038/ng1089

Kim, 2002, Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage, Genes Dev., 16, 560, 10.1101/gad.970602

Klengel, 2014, The role of DNA methylation in stress-related psychiatric disorders, Neuropharmacology, 80, 115, 10.1016/j.neuropharm.2014.01.013

Kumar, 2013, Therapeutic potential of GABAB receptor ligands in drug addiction, anxiety, depression and other CNS disorders, Pharmacol. Biochem. Behav., 110, 174, 10.1016/j.pbb.2013.07.003

Labonte, 2012, Genome-wide epigenetic regulation by early-life trauma, Arch. Gen. Psychiatry, 69, 722, 10.1001/archgenpsychiatry.2011.2287

Leek, 2012, The sva package for removing batch effects and other unwanted variation in high-throughput experiments, Bioinformatics, 28, 882, 10.1093/bioinformatics/bts034

Leslie, 2005, The physical, developmental, and mental health needs of young children in child welfare by initial placement type, J. Dev. Behav. Pediatr. JDBP, 26, 177, 10.1097/00004703-200506000-00003

Liang, 2014, Grasping nettles: cellular heterogeneity and other confounders in epigenome-wide association studies, Hum. Mol. Genet., 23, R83, 10.1093/hmg/ddu284

Lutz, 2014, DNA methylation and childhood maltreatment: from animal models to human studies, Neuroscience, 264, 142, 10.1016/j.neuroscience.2013.07.069

Mansson, 2014, DNAJB6 is a peptide-binding chaperone which can suppress amyloid fibrillation of polyglutamine peptides at substoichiometric molar ratios, Cell Stress Chaperones, 19, 227, 10.1007/s12192-013-0448-5

McCrory, 2012, The link between child abuse and psychopathology: a review of neurobiological and genetic research, J. R. Soc. Med., 105, 151, 10.1258/jrsm.2011.110222

McCrory, 2011, Heightened neural reactivity to threat in child victims of family violence, Curr. Biol., 21, R947, 10.1016/j.cub.2011.10.015

McCrory, 2015, The theory of latent vulnerability: reconceptualizing the link between childhood maltreatment and psychiatric disorder, Dev. Psychopathol., 27, 493, 10.1017/S0954579415000115

Mizushima, 2004, In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker, Mol. Biol. Cell, 15, 1101, 10.1091/mbc.E03-09-0704

Montesinos, 2005, Recycling and EH domain proteins at the synapse, Brain Res. Brain Res. Rev., 49, 416, 10.1016/j.brainresrev.2005.06.002

Muthen, 2011

Nakamura, 2005, Cloning and expression of a brain-specific putative UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase gene, Biol. Pharm. Bull., 28, 429, 10.1248/bpb.28.429

O'Brien, 2011, Amyloid precursor protein processing and Alzheimer's disease, Annu. Rev. Neurosci., 34, 185, 10.1146/annurev-neuro-061010-113613

Olivan, 2003, Catch-up growth assessment in long-term physically neglected and emotionally abused preschool age male children, Child. Abuse Negl., 27, 103, 10.1016/S0145-2134(02)00513-6

Pechtel, 2011, Effects of early life stress on cognitive and affective function: an integrated review of human literature, Psychopharmacol. Berl., 214, 55, 10.1007/s00213-010-2009-2

Pidsley, 2013, A data-driven approach to preprocessing Illumina 450K methylation array data, BMC Genomics, 14, 293, 10.1186/1471-2164-14-293

Prados, 2015, Borderline personality disorder and childhood maltreatment: a genome-wide methylation analysis, Genes Brain Behav., 14, 177, 10.1111/gbb.12197

Price, 2013, Additional annotation enhances potential for biologically-relevant analysis of the Illumina Infinium HumanMethylation450 BeadChip array, Epigenetics Chromatin, 6, 1, 10.1186/1756-8935-6-4

Radford, 2011

Rees, 2010, Understanding emotional abuse, Archives Dis. Child., 95, 59, 10.1136/adc.2008.143156

Roffe, 2013, IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2alpha kinase GCN2 in the modulation of neurite outgrowth, J. Biol. Chem., 288, 10860, 10.1074/jbc.M113.461970

Shalev, 2013, Exposure to violence during childhood is associated with telomere erosion from 5 to 10 years of age: a longitudinal study, Mol. Psychiatry, 18, 576, 10.1038/mp.2012.32

Sheridan, 2014, Dimensions of early experience and neural development: deprivation and threat, Trends Cogn. Sci., 18, 580, 10.1016/j.tics.2014.09.001

Sheskin, 2003

Smith, 2015, DNA extracted from saliva for methylation studies of psychiatric traits: evidence tissue specificity and relatedness to brain, Am. J. Med. Genet. B Neuropsychiatr. Genet., 168B, 36, 10.1002/ajmg.b.32278

Springer, 2007, Long-term physical and mental health consequences of childhood physical abuse: results from a large population-based sample of men and women, Child. Abuse Negl., 31, 517, 10.1016/j.chiabu.2007.01.003

Suderman, 2014, Childhood abuse is associated with methylation of multiple loci in adult DNA, BMC Med. Genomics, 7, 13, 10.1186/1755-8794-7-13

Sun, 2010, Allele-specific down-regulation of RPTOR expression induced by retinoids contributes to climate adaptations, PLoS Genet., 6, e1001178, 10.1371/journal.pgen.1001178

Timmons, 2015, Multiple sources of bias confound functional enrichment analysis of global -omics data, Genome Biol., 16, 186, 10.1186/s13059-015-0761-7

Traynelis, 2010, Glutamate receptor ion channels: structure, regulation, and function, Pharmacol. Rev., 62, 405, 10.1124/pr.109.002451

Tsai, 2015, Power and sample size estimation for epigenome-wide association scans to detect differential DNA methylation, Int. J. Epidemiol., 44, 1429, 10.1093/ije/dyv041

Turecki, 2016, Effects of the social environment and stress on glucocorticoid receptor gene methylation: a systematic review, Biol. Psychiatry, 79, 87, 10.1016/j.biopsych.2014.11.022

Vaillant, 2014, Antecedents of intact cognition and dementia at age 90 years: a prospective study, Int. J. Geriatr. Psychiatry, 29, 1278, 10.1002/gps.4108

Vandewalle, 2013, Ubiquitin ligase HUWE1 regulates axon branching through the Wnt/β-catenin pathway in a Drosophila model for intellectual disability, PLoS One, 8, e81791, 10.1371/journal.pone.0081791

World Health Organization, 2014

Yamamoto, 2015, Specific roles of NMDA receptor subunits in mental disorders, Curr. Mol. Med., 15, 193, 10.2174/1566524015666150330142807

Yang, 2013, Child abuse and epigenetic mechanisms of disease risk, Am. J. Prev. Med., 44, 101, 10.1016/j.amepre.2012.10.012