Gender-affirming hormonal treatment changes neural processing of emotions in trans men: An fMRI study

Psychoneuroendocrinology - Tập 146 - Trang 105928 - 2022
Meltem Kiyar1, Mary-Ann Kubre1, Sarah Collet2, Tibbert Van Den Eynde2, Guy T’Sjoen2, Antonio Guillamon3, Sven C. Mueller1
1Department of Experimental – Clinical and Health Psychology, Ghent University, Belgium
2Department of Endocrinology, Ghent University Hospital, Belgium
3Department of Psychobiology, National Distance Education University, Madrid, Spain

Tài liệu tham khảo

Adolphs, 2001, The neurobiology of social cognition, Curr. Opin. Neurobiol., 11, 231, 10.1016/S0959-4388(00)00202-6 Akitsuki, 2009, Social context and perceived agency affects empathy for pain: an event-related fMRI investigation, Neuroimage, 47, 722, 10.1016/j.neuroimage.2009.04.091 Balderston, 2011, The human amygdala plays a stimulus specific role in the detection of novelty, Neuroimage, 55, 1889, 10.1016/j.neuroimage.2011.01.034 Beck, 1996 Beking, 2020, Testosterone effects on functional amygdala lateralization: a study in adolescent transgender boys and cisgender boys and girls, Psychoneuroendocrinology, 111, 10.1016/j.psyneuen.2019.104461 Benjamini Y., Hochberg Y. (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society, Series B 57 (1): 289–300. Berboth, 2021, Amygdala-prefrontal connectivity during emotion regulation: A meta-analysis of psychophysiological interactions, Neuropsychologia, 153, 10.1016/j.neuropsychologia.2021.107767 Bos, 2012, Acute effects of steroid hormones and neuropeptides on human social-emotional behavior: a review of single administration studies, Front. Neuroendocrinol., 33, 17, 10.1016/j.yfrne.2011.01.002 Brett M., Anton J.L., Poline J.P. (2002) Region of interest analysis using an SPM tool-box. In 8th International Conference on Functional Mapping of the Human Brain. Browning, 2012, Expectancy and surprise predict neural and behavioral measures of attention to threatening stimuli, Neuroimage, 59, 1942, 10.1016/j.neuroimage.2011.09.007 Burke, 2016, Male-typical visuospatial functioning in gynephilic girls with gender dysphoria - organizational and activational effects of testosterone, J. Psychiatry Neurosci. JPN, 41, 395, 10.1503/jpn.150147 Burke, 2018, Testosterone effects on the brain in transgender men, Cereb. Cortex, 28, 1582, 10.1093/cercor/bhx054 Cohen, 2021, Allostatic stress and inflammatory biomarkers in transgender and gender expansive youth: protocol for a pilot cohort study, JMIR Res. Protoc., 10, 10.2196/24100 Cohen, 2008, Amygdala tractography predicts functional connectivity and learning during feedback-guided decision-making, Neuroimage, 39, 1396, 10.1016/j.neuroimage.2007.10.004 Cohen, 1983, A global measure of perceived stress, J. Health Soc. Behav., 24, 385, 10.2307/2136404 Comte, 2016, Dissociating bottom-up and top-down mechanisms in the cortico-limbic system during emotion processing, Cereb. Cortex, 26, 144, 10.1093/cercor/bhu185 Cromwell, 2020, Mapping the interconnected neural systems underlying motivation and emotion: a key step toward understanding the human affectome, Neurosci. Biobehav. Rev., 113, 204, 10.1016/j.neubiorev.2020.02.032 Davis, 2016, Interpreting ambiguous social cues in unpredictable contexts, Soc. Cogn. Affect Neurosci., 11, 775, 10.1093/scan/nsw003 Di, 2017, Task modulated brain connectivity of the amygdala: a meta-analysis of psychophysiological interactions, Brain Struct. Funct., 222, 619, 10.1007/s00429-016-1239-4 Donges, 2012, Women’s greater ability to perceive happy facial emotion automatically: Gender differences in affective priming, PLoS One, 7, 10.1371/journal.pone.0041745 Erk, 2010, Acute and sustained effects of cognitive emotion regulation in major depression, J. Neurosci., 30, 15726, 10.1523/JNEUROSCI.1856-10.2010 Fine, 2009, Gender differences in BOLD activation to face photographs and video vignettes, Behav. Brain Res., 201, 137, 10.1016/j.bbr.2009.02.009 Fusar-Poli, 2009, Distinct effects of {delta}9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing, Arch. Gen. Psychiatry, 66, 95, 10.1001/archgenpsychiatry.2008.519 Grannis, 2021, Testosterone treatment, internalizing symptoms, and body image dissatisfaction in transgender boys, Psychoneuroendocrinology, 132, 10.1016/j.psyneuen.2021.105358 Haberkamp, 2015, Interpretative bias in spider phobia: perception and information processing of ambiguous schematic stimuli, Acta Psychol., 160, 184, 10.1016/j.actpsy.2015.07.011 Hoffmann, 2010, Expression intensity, gender and facial emotion recognition: women recognize only subtle facial emotions better than men, Acta Psychol., 135, 278, 10.1016/j.actpsy.2010.07.012 Hulshoff Pol, 2006, Changing your sex changes your brain: influences of testosterone and estrogen on adult human brain structure, Eur. J. Endocrinol., 107 Kinsey, 1948, Kinsey Scale [Database record], APA PsycTests Kinsey, 1953 Kiyar, 2022, Minority stress and the effects on emotion processing in transgender men and cisgender people: a study combining fMRI and 1H-MRS, Int. J. Neuropsychopharmacol., 25, 350, 10.1093/ijnp/pyab090 Kranz, 2020, Gender-affirming hormone treatment - A Unique approach to study the effects of sex hormones on brain structure and function, Cortex J. Devoted Study Nerv. Syst. Behav., 129, 68, 10.1016/j.cortex.2020.04.005 Martin, 2009, The neurobiology of anxiety disorders: brain imaging, genetics, and psychoneuroendocrinology, Psychiatr. Clin. North Am., 32, 549, 10.1016/j.psc.2009.05.004 Mende-Siedlecki, 2013, The social evaluation of faces: a meta-analysis of functional neuroimaging studies, Soc. Cogn. Affect. Neurosci., 8, 285, 10.1093/scan/nsr090 Meyer, 2003, Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence, Psychol. Bull., 129, 674, 10.1037/0033-2909.129.5.674 Mueller, 2009, Early hyperandrogenism affects the development of hippocampal function: preliminary evidence from a functional magnetic resonance imaging study of boys with familial male precocious puberty, J. Child Adolesc. Psychopharmacol., 19, 41, 10.1089/cap.2008.031 Neufang, 2009, Sex differences and the impact of steroid hormones on the developing human brain, Cereb. Cortex, 19, 464, 10.1093/cercor/bhn100 Peper, 2011, Sex steroids and brain structure in pubertal boys and girls: a mini-review of neuroimaging studies, Neuroscience, 191, 28, 10.1016/j.neuroscience.2011.02.014 Perez-Laso, 2018, Effects of adult female rat androgenization on brain morphology and metabolomic profile, Cerebral cortex (New York, N.Y. : 1991), 28, 2846, 10.1093/cercor/bhx163 Plichta, 2014, Amygdala habituation: a reliable fMRI phenotype, Neuroimage, 103, 383, 10.1016/j.neuroimage.2014.09.059 Roberts, 2000, Sex differences on a mental rotation task: variations in electroencephalogram hemispheric activation between children and college students, Dev. Neuropsychol., 17, 199, 10.1207/S15326942DN1702_04 Seiger, 2016, Subcortical gray matter changes in transgender subjects after long-term cross-sex hormone administration, Psychoneuroendocrinology, 74, 371, 10.1016/j.psyneuen.2016.09.028 Sheehan, 1998, The Mini-international Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10, J Clin Psychiatry, 59, 22 Soleman, 2016, Oestrogens are not related to emotional processing: a study of regional brain activity in female-to-male transsexuals under gonadal suppression, Cereb. Cortex, 26, 510 Sommer, 2008, Effects of cross-sex hormones on cerebral activation during language and mental rotation: An fMRI study in transsexuals, Eur. Neuropsychopharmacol., 215, 10.1016/j.euroneuro.2007.10.002 Spielberger, 1983 Stevens, 2012, Sex differences in brain activation to emotional stimuli: a meta-analysis of neuroimaging studies, Neuropsychologia, 50, 1578, 10.1016/j.neuropsychologia.2012.03.011 Stoet, 2013, Sex differences in mathematics and reading achievement are inversely related: within- and across-nation assessment of 10 years of PISA data, PLoS One, 8, 10.1371/journal.pone.0057988 Toffoletto, 2014, Emotional and cognitive functional imaging of estrogen and progesterone effects in the female human brain: a systematic review, Psychoneuroendocrinology, 50, 28, 10.1016/j.psyneuen.2014.07.025 Tordoff, 2022, Mental health outcomes in transgender and nonbinary youths receiving gender-affirming care, JAMA Netw. Open, 5, 10.1001/jamanetworkopen.2022.0978 Tottenham, 2009, The NimStim set of facial expressions: judgments from untrained research participants, Psychiatry Res., 168, 242, 10.1016/j.psychres.2008.05.006 van Honk, 2005, Testosterone reduces unconscious fear but not consciously experienced anxiety: implications for the disorders of fear and anxiety, Biol. Psychiatry, 58, 218, 10.1016/j.biopsych.2005.04.003 van Wingen, 2010, Testosterone reduces amygdala-orbitofrontal cortex coupling, Psychoneuroendocrinology, 35, 105, 10.1016/j.psyneuen.2009.09.007 Voyer, 1995, Magnitude of sex differences in spatial abilities: a meta-analysis and consideration of critical variables, Psychol. Bull., 117, 250, 10.1037/0033-2909.117.2.250 Vrticka, 2014, Human amygdala response to dynamic facial expressions of positive and negative surprise, Emotion, 14, 161, 10.1037/a0034619 Xu, 2013, Neural basis of emotional decision making in trait anxiety, J. Neurosci., 33, 18641, 10.1523/JNEUROSCI.1253-13.2013 Zubiaurre-Elorza, 2014, Effects of cross sex hormone treatment on cortical thickness in transsexual individuals, J. Sex. Med., 1248, 10.1111/jsm.12491