AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

Nature - Tập 428 Số 6982 - Trang 569-574 - 2004
Yasuhiko Minokoshi1, Thierry Alquier1, Noboru Furukawa1, Young‐Bum Kim1, Anna Lee1, Bingzhong Xue1, James Mu2, Fabienne Foufelle3, Pascal Ferré3, Morris J. Birnbaum2, Bettina J. Stuck1, Barbara B. Kahn1
1Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, USA
2Howard Hughes Medical Institute, The Cox Institute, University of Pennsylvania Medical School, Philadelphia, USA
3Unit 465 INSERM, Centre de Recherches Biomedicales des Cordeliers, Paris, France

Tóm tắt

Từ khóa


Tài liệu tham khảo

Hardie, D. G., Scott, J. W., Pan, D. A. & Hudson, E. R. Management of cellular energy by the AMP-activated protein kinase system. FEBS Lett. 546, 113–120 (2003)

Schwartz, M. W. et al. Central nervous system control of food intake. Nature 404, 661–671 (2000)

Friedman, J. M. & Halaas, J. L. Leptin and the regulation of body weight in mammals. Nature 395, 763–770 (1998)

Brüning, J. C. et al. Role of brain insulin receptor in control of body weight and reproduction. Science 289, 2122–2125 (2000)

Levin, B. E. Glucosensing neurons do more than just sense glucose. Int. J. Obes. Relat. Metab. Disord. Suppl. 5, S68–S72 (2001)

Obici, S. et al. Central administration of oleic acid inhibits glucose production and food intake. Diabetes 5, 271–275 (2002)

Hawley, S. A. et al. Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade. J. Biol. 2(28), 1–16 (2003)

Turnley, A. M. et al. Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J. Neurochem. 72, 1707–1716 (1999)

Culmsee, C., Monnig, J., Kemp, B. E. & Mattson, M. P. AMP-activated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivation. J. Mol. Neurosci. 17, 45–58 (2001)

Elmquist, J. K., Elias, C. F. & Saper, C. B. From lesions to leptin: hypothalamic control of food intake and body weight. Neuron 22, 221–232 (1999)

Obici, S., Zhang, B. B., Karkanias, G. & Rossetti, L. Hypothalamic insulin signaling is required for inhibition of glucose production. Nature Med. 8, 1376–1382 (2002)

Ollmann, M. M. et al. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278, 135–138 (1977)

Woods, A. et al. Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase. Mol. Cell. Biol. 20, 6704–6711 (2000)

Viollet, B. et al. The AMP-activated protein kinase α2 catalytic subunit controls whole-body insulin sensitivity. J. Clin. Invest. 111, 91–98 (2003)

Andersson, U. et al. AMP-activated protein kinase plays a role in the control of food intake. J. Biol. Chem. published online 23 January 2004 (doi:10.1074/jbc.C300557200)

Bates, S. H. et al. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 421, 856–859 (2003)

Niswender, K. D. et al. Intracellular signalling. Key enzyme in leptin-induced anorexia. Nature 413, 794–795 (2001)

Zhao, A.-Z. et al. A phosphatidylinositol 3-kinase-phosphodiesterase 3B-cyclic AMP in hypothalamic action of leptin on feeding. Nature Neurosci. 5, 727–728 (2002)

Obici, S. et al. Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production. Nature Med. 9, 756–761 (2003)

Cowley, M. A. et al. Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat. Neuron 24, 155–163 (1999)

Light, P. E., Wallace, C. H. R. & Dyck, J. R. B. Constitutively active adenosine monophosphate-activated protein kinase regulates voltage-gated sodium channels. Circulation 107, 1962–1965 (2003)

Hallows, K. R. et al. Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase. J. Clin. Invest. 12, 1711–1721 (2000)

da Silva Xavier, G. et al. Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression. Biochem. J. 371, 761–774 (2003)

Spanswick, D. et al. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 390, 521–525 (1997)

Spanswick, D. et al. Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats. Nature Neurosci. 3, 757–758 (2000)

Loftus, T. M. et al. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288, 2379–2381 (2000)

Hu, Z., Cha, S. H., Chohnan, S. & Lane, D. Hypothalamic malonyl-CoA as a mediator of feeding behavior. Proc. Natl Acad. Sci. USA 100, 12624–12629 (2003)

Ruderman, N. B., Saha, A. K., Vavvas, E. & Witters, L. A. Malonyl-CoA, fuel sensing, and insulin resistance. Am. J. Physiol. 276, E1–E18 (1999)

Minokoshi, Y. et al. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415, 339–343 (2002)

Woods, S. et al. The α1 and α2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro. FEBS Lett. 397, 347–351 (1996)

Hayashi, T. et al. Metabolic stress and altered glucose transport. Activation of AMP-activated protein kinase as a unifying coupling mechanism. Diabetes 49, 527–531 (2000)