Sequence and evolution of cattle MHC class I cDNAs: concerted evolution has not taken place in cattle

Immunogenetics - Tập 38 - Trang 11-20 - 1993
Theodore L. Garber1, Austin L. Hughes2, Norman L. Letvin3, Joe W. Templeton1, David I. Watkins4
1Department of Veterinary Pathobiology, Texas A&M University, College Station, USA.
2Department of Biology, Pennsylvania State University, University Park, USA
3New England Regional Primate Research Center, Harvard Medical School, Southborough, USA
4Dept. of Pathology and the Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, USA

Tóm tắt

To explore genetic mechanisms responsible for major histocompatibility complex (MHC) class I evolution in the artiodactyls, we cloned and sequenced MHC class I cDNAs from a Bos taurus bull heterozygous for cattle MHC (BoLA) class I serological specificities w2 and w30. Four unique cDNAs were found, indicating the presence of at least two MHC class I loci. Analysis of these four cDNAs and all previously published BoLA cDNA sequences suggested that there may be three cattle MHC class I loci. Additionally, comparison of all of the BoLA class I cDNAs to MHC class I cDNAs of other artiodactyls showed that some of the BoLA class I cDNAs were more similar to certain sheep cDNAs than they were to other cattle cDNAs. These data indicate that each BoLA class I locus has evolved independently after an ancestral gene duplication event and that inter-locus segmental exchange o or concerted evolution has not occurred rapidly enough to cause extensive divergence between the orthologous MHC class I loci of sheep and cattle.

Tài liệu tham khảo

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