SOX6 Attenuates Glucose-stimulated Insulin Secretion by Repressing PDX1 Transcriptional Actvity and Is Down-regulated in Hyperinsulinemic Obese Mice

Journal of Biological Chemistry - Tập 280 - Trang 37669-37680 - 2005
Haruhisa Iguchi1,2, Yukio Ikeda2, Masashi Okamura1, Toshiya Tanaka1, Yasuyo Urashima1, Hiroto Ohguchi1, Shinobu Takayasu2, Noriaki Kojima1, Satoshi Iwasaki1,2, Riuko Ohashi3, Shuying Jiang3, Go Hasegawa3, Ryoichi X. Ioka1,2, Kenta Magoori1, Koichi Sumi1, Takashi Maejima1, Aoi Uchida1, Makoto Naito3, Timothy F. Osborne4, Masashi Yanagisawa2,5
1Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo 153-8904, Japan
2Yanagisawa Orphan Receptor Project, Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Tokyo 135-0064, Japan
3Department of Cellular Function, Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan
4Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92717-3900
5Howard Hughes Medical Institute and Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9050

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Journal of Biological Chemistry

Tập 280

37669-37680

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