Predicting the Spread of COVID-19 Using $$SIR$$ Model Augmented to Incorporate Quarantine and Testing

Springer Science and Business Media LLC - Tập 5 - Trang 141-148 - 2020
Nikhil Anand1, A. Sabarinath1, S. Geetha1, S. Somanath1
1Vikram Sarabhai Space Centre, Trivandrum, India

Tóm tắt

India imposed a nationwide lockdown from 25th March 2020 onwards to combat the spread of COVID-19 pandemic. To model the spread of a disease and to predict its future course, epidemiologists make use of compartmental models such as the $$SIR$$ model. In order to address some of the assumptions of the standard $$SIR$$ model, a new modified version of $$SIR$$ model is proposed in this paper that takes into account the percentage of infected individuals who are tested and quarantined. This approach helps overcome the assumption of homogenous mixing of population which is inherent to the conventional $$SIR$$ model. Using the available data of the number of COVID-19 positive cases reported in the state of Kerala, and in India till 26th April, 2020 and 12th May 2020, respectively, the parameter estimation problem is converted into an optimization problem with the help of a least squared cost function. The optimization problem is then solved using differential evolution optimizer. The impact of lockdown is quantified by comparing the rising trend in infections before and during the lockdown. Using the estimated set of parameters, the model predicts that in the state of Kerala, by using certain interventions the pandemic can be successfully controlled latest by the first week of July, whereas the $${R}_{0}$$ value for India is still greater than 1, and hence lifting of lockdown from all regions of the country is not advisable.

Tài liệu tham khảo

Adamu HA, Murtala M, Abdullahi MJ, Mahmud AU (2019) Mathematical modelling using improved SIR model with more realistic assumptions. Int J Eng Appl Sci. https://doi.org/10.31873/IJEAS.6.1.22 Aravind LR et al (2020) epidemic landscape and forecasting of SARS-CoV-2 in India. Preprint at https://www.medrxiv.org/content/10.1101/2020.04.14.20065151v1 Crowdsourced India COVID-19 tracker data. https://bit.ly/patientdb Ferguson N et al (2020) Report-9, impact of non-pharmaceutical interventions (NPIs) to reduce COVID-19 mortality and healthcare demand. Imperial College COVID-19 response team, Imperial College London Lopez L, Roda X (2020) A Modified SEIR model to predict COVID-19 outbreak in Spain and Italy: simulating control scenarios and multi scale epidemics. Preprint at https://www.medrxiv.org/content/10.1101/2020.03.27.20045005v3 Ministry of Health and Family Welfare, Government of India (2020). District Wise list of reported Cases Our world in data : Coronavirus Source Data. https://ourworldindata.org/coronavirus-source-data Peng L et al (2020) Epidemic analysis of COVID-19 in China by dynamic modelling. Preprint at https://www.medrxiv.org/content/10.1101/2020.02.16.20023465v1 Report of WHO-China joint mission on Coronavirus Disease 2019 (2020) World Health Organization Situation Report-113 Coronavirus Disease 2019 (2020), World Health Organization Sanders JM, Marguerite LM, Tomasz ZJ, James BC (2020) Pharmacologic treatments for Coronavirus Disease 2019—a review. JAMA 323(18):1824–1836. https://doi.org/10.1001/jama.2020.6019 Situation Report-91, Coronavirus Disease 2019 (2020) World Health Organization Situation Report-3, Coronavirus Disease 2019 (2020) World Health Organization. https://www.who.int/docs/default-source/wrindia/situation-report/india-situation-report-3.pdf?sfvrsn=790bf1bd_2 Storn R, Price K (1997) Differential evolution—a simple and efficient adaptive scheme for global optimization over continuous spaces. J Glob Optim. https://doi.org/10.1023/A:1008202821328