Cyclin D1 expression is associated with poor prognostic features in estrogen receptor positive breast cancer

Springer Science and Business Media LLC - Tập 113 - Trang 75-82 - 2008
Kirsimari Aaltonen1,2, Rose-Marie Amini3, Göran Landberg4, Hannaleena Eerola1,2, Kristiina Aittomäki5, Päivi Heikkilä6, Heli Nevanlinna2, Carl Blomqvist1,7
1Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
2Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland
3Department of Genetics and Pathology, Uppsala University Hospital, Uppsala, Sweden
4Division of Pathology, Institution of Laboratory Medicine, Malmö University Hospital, Malmo, Sweden
5Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland
6Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland
7Department of Oncology, Radiology and Clinical Immunology, Uppsala University Hospital, Uppsala, Sweden

Tóm tắt

Cyclins D1 and E play an important role in breast carcinogenesis. High cyclin E expression is common in hormone receptor negative and high grade aggressive breast cancer, whereas cyclin D1 in hormone receptor positive and low grade breast cancer. Experimental data has suggested that cyclin D1 and E mediate cell proliferation by different mechanisms in estrogen receptor (ER) positive and negative breast cancer. To test this hypotheses in large breast cancer material and to clarify the histopathological correlations of cyclin E and D1, especially the association with proliferation, we analyzed cyclin E and D1 immunohistochemical expression on breast tumour microarrays consisting of 1348 invasive breast cancers. High cyclin D1 expression was associated with high grade (P < 0.0005), high cyclin A (P < 0.0005) and Ki67 (P < 0.0005) expression among ER positive but with low grade (P = 0.05) and low Ki67 (P = 0.01) expression among ER negative breast cancers. Cyclin E and D1 expression correlated positively in ER positive (P < 0.0005) but had a negative correlation in ER negative tumours (P = 0.004). Cyclin E associated with high grade among all tumours (P < 0.0005). In conclusion, the findings of this study show that cyclin D1 has separate roles, and proliferation is driven by different mechanisms in ER positive and negative breast cancers.

Tài liệu tham khảo

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