Wip1 directly dephosphorylates NLK and increases Wnt activity during germ cell development

Lowe, 2012, Regulation of the Wip1 phosphatase and its effects on the stress response, Front. Biosci., 17, 1480, 10.2741/3999 Sun, 2014, Phosphatase Wip1 negatively regulates neutrophil migration and inflammation, J. Immunol., 192, 1184, 10.4049/jimmunol.1300656 Yi, 2015, Phosphatase Wip1 controls antigen-independent B cell development in a p53-dependent manner, Blood, 10.1182/blood-2015-02-624114 Chen, 2015, Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways, Nat. Commun., 6, 6808, 10.1038/ncomms7808 Jeong, 2015, Timely Degradation of Wip1 Phosphatase by APC/C Activator Protein Cdh1 is Necessary for Normal Mitotic Progression, J. Cell. Biochem., 116, 1602, 10.1002/jcb.25114 Le Guezennec, 2012, Wip1-dependent regulation of autophagy, obesity, and atherosclerosis, Cell Metab., 16, 68, 10.1016/j.cmet.2012.06.003 Filipponi, 2013, Wip1 controls global heterochromatin silencing via ATM/BRCA1-dependent DNA methylation, Cancer Cell, 24, 528, 10.1016/j.ccr.2013.08.022 Choi, 2002, Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control, Mol. Cell. Biol., 22, 1094, 10.1128/MCB.22.4.1094-1105.2002 Zhu, 2009, Wip1 regulates the generation of new neural cells in the adult olfactory bulb through p53-dependent cell cycle control, Stem Cells, 27, 1433, 10.1002/stem.65 Lee, 2009, Senescent growth arrest in mesenchymal stem cells is bypassed by Wip1-mediated downregulation of intrinsic stress signaling pathways, Stem Cells, 27, 1963, 10.1002/stem.121 Zhu, 2014, Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging, J. Clin. Invest., 124, 3263, 10.1172/JCI73015 Cha, 2013, The modulation of the oxidative stress response in chondrocytes by Wip1 and its effect on senescence and dedifferentiation during in vitro expansion, Biomaterials, 34, 2380, 10.1016/j.biomaterials.2012.12.009 Clevers, 2012, Wnt/beta-catenin signaling and disease, Cell, 149, 1192, 10.1016/j.cell.2012.05.012 Golestaneh, 2009, Wnt signaling promotes proliferation and stemness regulation of spermatogonial stem/progenitor cells, Reproduction, 138, 151, 10.1530/REP-08-0510 Dong, 2015, Wnt signaling in testis development: Unnecessary or essential?, Gene, 565, 155, 10.1016/j.gene.2015.04.066 Brott, 1998, Nlk is a murine protein kinase related to Erk/MAP kinases and localized in the nucleus, Proc. Natl. Acad. Sci. U. S. A., 95, 963, 10.1073/pnas.95.3.963 Kehrer-Sawatzki, 2000, Characterization of the Fugu rubripes NLK and FN5 genes flanking the NF1 (Neurofibromatosis type 1) gene in the 5' direction and mapping of the human counterparts, Gene, 251, 63, 10.1016/S0378-1119(00)00188-8 Ishitani, 2003, Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling, Mol. Cell. Biol., 23, 1379, 10.1128/MCB.23.4.1379-1389.2003 Ishitani, 1999, The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF, Nature, 399, 798, 10.1038/21674 Ota, 2012, NLK positively regulates Wnt/beta-catenin signalling by phosphorylating LEF1 in neural progenitor cells, EMBO J., 31, 1904, 10.1038/emboj.2012.46 Lv, 2014, Nemo-like kinase (NLK) inhibits the progression of NSCLC via negatively modulating WNT signaling pathway, J. Cell. Biochem., 115, 81, 10.1002/jcb.24635 Sa, 2015, In vivo RNAi screen identifies NLK as a negative regulator of mesenchymal activity in glioblastoma, Oncotarget, 6, 20145, 10.18632/oncotarget.3980 Yoshimizu, 1999, Germline-specific expression of the Oct-4/green fluorescent protein (GFP) transgene in mice, Develop. Growth Differ., 41, 675, 10.1046/j.1440-169x.1999.00474.x West, 2009, A role for Lin28 in primordial germ-cell development and germ-cell malignancy, Nature, 460, 909, 10.1038/nature08210 Veeman, 2003, Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements, Curr. biol., 13, 680, 10.1016/S0960-9822(03)00240-9 Cha, 2010, Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response, Cancer Res., 70, 4112, 10.1158/0008-5472.CAN-09-4244 Shtutman, 1999, The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway, Proc. Natl. Acad. Sci. U. S. A., 96, 5522, 10.1073/pnas.96.10.5522 Bulavin, 2002, Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity, Nat. Genet., 31, 210, 10.1038/ng894 Lee, 2014, Off-target response of a Wip1 chemical inhibitor in skin keratinocytes, J. Dermatol. Sci., 73, 125, 10.1016/j.jdermsci.2013.09.003 Yang, 2008, Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling, Nat. Genet., 40, 1130, 10.1038/ng.192 Shimizu, 1997, Transformation by Wnt family proteins correlates with regulation of beta-catenin, Cell Growth Differ., 8, 1349 Young, 1998, Wnt-1 induces growth, cytosolic beta-catenin, and Tcf/Lef transcriptional activation in Rat-1 fibroblasts, Mol. Cell. Biol., 18, 2474, 10.1128/MCB.18.5.2474 Ishitani, 2011, Homodimerization of Nemo-like kinase is essential for activation and nuclear localization, Mol. Biol. Cell, 22, 266, 10.1091/mbc.e10-07-0605 Ishitani, 2013, Nemo-like kinase, a multifaceted cell signaling regulator, Cell. Signal., 25, 190, 10.1016/j.cellsig.2012.09.017 Takekawa, 2000, p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation, EMBO J., 19, 6517, 10.1093/emboj/19.23.6517 Wilson, 1996, Crystal structure of p38 mitogen-activated protein kinase, J. Biol. Chem., 271, 27696, 10.1074/jbc.271.44.27696 Yamaguchi, 2007, The Wip1 phosphatase PPM1D dephosphorylates SQ/TQ motifs in checkpoint substrates phosphorylated by PI3K-like kinases, Biochemistry, 46, 12594, 10.1021/bi701096s Cheng, 2012, Nemo-like kinase promotes etoposide-induced apoptosis of male germ cell-derived GC-1 cells in vitro, FEBS Lett., 586, 1497, 10.1016/j.febslet.2012.04.005 Hofmann, 1992, Immortalization of germ cells and somatic testicular cells using the SV40 large T antigen, Exp. Cell Res., 201, 417, 10.1016/0014-4827(92)90291-F Mather, 1980, Establishment and characterization of two distinct mouse testicular epithelial cell lines, Biol. Reprod., 23, 243, 10.1095/biolreprod23.1.243 Campolo, 2013, Essential role of Sox2 for the establishment and maintenance of the germ cell line, Stem Cells, 31, 1408, 10.1002/stem.1392 Blanco, 2000, The alpha4 isoform of the Na,K-ATPase is expressed in the germ cells of the testes, J. Histochem. Cytochem., 48, 1023, 10.1177/002215540004800801 Tay, 2008, MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation, Nature, 455, 1124, 10.1038/nature07299 Castrillon, 2000, The human VASA gene is specifically expressed in the germ cell lineage, Proc. Natl. Acad. Sci. U. S. A., 97, 9585, 10.1073/pnas.160274797 Tsuda, 2003, Conserved role of nanos proteins in germ cell development, Science, 301, 1239, 10.1126/science.1085222 Youngren, 2005, The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours, Nature, 435, 360, 10.1038/nature03595 Irie, 2015, SOX17 is a critical specifier of human primordial germ cell fate, Cell, 160, 253, 10.1016/j.cell.2014.12.013 Suzuki, 2008, Nanos3 maintains the germ cell lineage in the mouse by suppressing both Bax-dependent and -independent apoptotic pathways, Dev. Biol., 318, 133, 10.1016/j.ydbio.2008.03.020 Weidinger, 2003, dead end, a novel vertebrate germ plasm component, is required for zebrafish primordial germ cell migration and survival, Curr. Biol., 13, 1429, 10.1016/S0960-9822(03)00537-2 Engert, 2013, Wnt/beta-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse, Development, 140, 3128, 10.1242/dev.088765 Demidov, 2007, Wip1 phosphatase regulates p53-dependent apoptosis of stem cells and tumorigenesis in the mouse intestine, Cell Stem Cell, 1, 180, 10.1016/j.stem.2007.05.020 Tang, 2015, Wip1 knockout inhibits the proliferation and enhances the migration of bone marrow mesenchymal stem cells, Exp. Cell Res., 334, 310, 10.1016/j.yexcr.2015.03.018 Sato, 2008, Wingless signaling initiates mitosis of primordial germ cells during development in Drosophila, Mech. Dev., 125, 498, 10.1016/j.mod.2008.01.004 Lyashenko, 2011, Differential requirement for the dual functions of beta-catenin in embryonic stem cell self-renewal and germ layer formation, Nat. Cell Biol., 13, 753, 10.1038/ncb2260 Kortenjann, 2001, Abnormal bone marrow stroma in mice deficient for nemo-like kinase Nlke, Eur. J. Immunol., 31, 3580, 10.1002/1521-4141(200112)31:12<3580::AID-IMMU3580>3.0.CO;2-N Lie, 2005, Wnt signalling regulates adult hippocampal neurogenesis, Nature, 437, 1370, 10.1038/nature04108 Emelyanov, 2015, Wip1 phosphatase in breast cancer, Oncogene, 34, 4429, 10.1038/onc.2014.375