Acute and chronic animal models for the evaluation of anti-diabetic agents

Springer Science and Business Media LLC - Tập 11 - Trang 1-13 - 2012
Suresh Kumar1, Rajeshwar Singh1, Neeru Vasudeva1, Sunil Sharma1
1Pharmacology Division, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, India

Tóm tắt

Diabetes mellitus is a potentially morbid condition with high prevalence worldwide thus being a major medical concern. Experimental induction of diabetes mellitus in animal models is essential for the advancement of our knowledge and understanding of the various aspects of its pathogenesis and ultimately finding new therapies and cure. Experimental diabetes mellitus is generally induced in laboratory animals by several methods that include: chemical, surgical and genetic (immunological) manipulations. Most of the experiments in diabetes are carried out in rodents, although some studies are still performed in larger animals. The present review highlights the various methods of inducing diabetes in experimental animals in order to test the newer drugs for their anti-diabetic potential.

Tài liệu tham khảo

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