Idiopathic rapid eye movement sleep behaviour disorder: diagnosis, management, and the need for neuroprotective interventions

Silber, 2004, Physiological basis of sleep, 3 2014 Schenck, 2002, REM sleep behavior disorder: clinical, developmental, and neuroscience perspectives 16 years after its formal identification in SLEEP, Sleep, 25, 120, 10.1093/sleep/25.2.120 Boeve, 2010, REM sleep behaviour disorder. Updated review of the core features, the REM sleep behavior disorder-neurodegenerative disease association, evolving concepts, controversies, and future directions, Ann NY Acad Sci, 1184, 15, 10.1111/j.1749-6632.2009.05115.x Arnulf, 2012, REM sleep behavior disorder: motor manifestations and pathophysiology, Mov Disord, 27, 677, 10.1002/mds.24957 Peever, 2014, Breakdown in REM sleep circuitry underlies REM sleep behavior disorder, Trends Neurosci, 37, 279, 10.1016/j.tins.2014.02.009 Schenck, 1996, Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder, Neurology, 46, 388, 10.1212/WNL.46.2.388 Schenck, 2013, Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder: a 16-year update on a previously reported series, Sleep Med, 14, 744, 10.1016/j.sleep.2012.10.009 Iranzo, 2006, Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disease: a descriptive study, Lancet Neurol, 5, 572, 10.1016/S1474-4422(06)70476-8 Iranzo, 2013, Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behavior disorder: an observational cohort study, Lancet Neurol, 12, 443, 10.1016/S1474-4422(13)70056-5 Iranzo, 2014, Neurodegenerative disorder risk in idiopathic REM sleep behavior disorder: study in 174 patients, PLoS One, 9, e89741, 10.1371/journal.pone.0089741 Postuma, 2009, Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder, Neurology, 72, 1296, 10.1212/01.wnl.0000340980.19702.6e Postuma, 2015, Parkinson risk in idiopathic REM sleep behavior disorder: preparing for neuroprotective trials, Neurology, 84, 1104, 10.1212/WNL.0000000000001364 Wing, 2012, Prospective outcome of rapid eye movement sleep behaviour disorder: psychiatric disorders as a potential early marker of Parkinson's disease, J Neurol Neurosurg Psychiatry, 83, 470, 10.1136/jnnp-2011-301232 Youn, 2015, Progression of cognitive impairments in idiopathic REM sleep behavior disorder, J Neurol Neurosurg Psychiatry, 10.1136/jnnp-2015-311437 Postuma, 2015, Risk factors for neurodegeneration in idiopathic rapid eye movement sleep behavior disorder: a multicenter study, Ann Neurol, 77, 830, 10.1002/ana.24385 Boeve, 2013, Idiopathic REM sleep behaviour disorder in the development of Parkinson's disease, Lancet Neurol, 12, 469, 10.1016/S1474-4422(13)70054-1 Boot, 2012, Probable rapid eye movement sleep behavior disorder increases risk for mild cognitive impairment and Parkinson disease: a population based study, Ann Neurol, 71, 49, 10.1002/ana.22655 Mahlknecht, 2015, Probable RBD and association with neurodegenerative disease markers: a population-based study, Mov Disord, 30, 1417, 10.1002/mds.26350 Chiu, 2000, Sleep-related injury in the elderly-an epidemiological study in Hong Kong, Sleep, 23, 513, 10.1093/sleep/23.4.1f Kang, 2013, REM sleep behavior disorder in the Korean elderly population: prevalence and clinical characteristics, Sleep, 36, 1147, 10.5665/sleep.2874 Schrag, 2014, Prediagnostic presentations of Parkinson's disease in primary care: a case-control study, Lancet Neurol, 14, 57, 10.1016/S1474-4422(14)70287-X Iranzo, 2005, Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD, Neurology, 65, 247, 10.1212/01.wnl.0000168864.97813.e0 White, 2012, Diagnostic delay in REM sleep behavior disorder (RBD), J Clin Sleep Med, 8, 133, 10.5664/jcsm.1762 Fernández-Arcos, 2016, The clinical phenotype of idiopathic REM sleep behavior disorder at presentation: a study in 203 consecutive patients, Sleep, 39, 121, 10.5665/sleep.5332 Oudiette, 2009, Nonviolent elaborate behaviors may also occur in REM sleep behavior disorder, Neurology, 72, 551, 10.1212/01.wnl.0000341936.78678.3a Santamaria, 2004, Relation between dream content and movement intensity in REM sleep behavior disorder, Sleep, 27, A289 Schenck, 2009, Potentially lethal behaviors associated with rapid eye movement sleep behavior disorder (RBD): review of the literature and forensic implications, J Forensic Sci, 54, 1475, 10.1111/j.1556-4029.2009.01163.x Uguccioni, 2013, Fight or flight? Dream content during sleepwalking/sleep terrors vs. rapid eye movement sleep behavior disorder, Sleep Med, 14, 391, 10.1016/j.sleep.2013.01.014 Wing, 2008, REM sleep behaviour disorder in Hong Kong Chinese: clinical outcome and gender comparison, J Neurol Neurosurg Psychiatry, 79, 1415, 10.1136/jnnp.2008.155374 Fantini, 2005, Aggressive dream content without daytime aggressiveness in REM sleep behavior disorders, Neurology, 65, 1010, 10.1212/01.wnl.0000179346.39655.e0 Bodkin, 2009, Rapid eye movement sleep behavior disorder in women: relevance to general and speciality medical practice, J Women Health, 18, 1955, 10.1089/jwh.2008.1348 Iranzo, 2007, Absence of alterations in serum sex hormones levels in idiopathic REM sleep behavior disorder, Sleep, 30, 803, 10.1093/sleep/30.6.803 Zhou, 2015, Gender differences in REM sleep behavior disorder: a clinical and polysomnographic study in China, Sleep Med, 16, 414, 10.1016/j.sleep.2014.10.020 Bjonara, 2013, REM sleep behavior disorder in Parkinson's disease—is there a gender difference?, Parkinsonism Related Disord, 19, 120, 10.1016/j.parkreldis.2012.05.027 Classen, 2010, REM sleep behavior disorder preceding other aspects of synucleinoipathies by up to half century, Neurology, 75, 494, 10.1212/WNL.0b013e3181ec7fac Ohayon, 2010, Violent behavior during sleep: prevalence, comorbidity and consequences, Sleep Med, 11, 941, 10.1016/j.sleep.2010.02.016 Ju, 2013, Rapid eye movement sleep behavior disorder in adults younger than 50 years of age, Sleep Med, 14, 768, 10.1016/j.sleep.2012.09.026 Tolosa, 2011, Progress in defining the premotor phase of Parkinson's disease, J Neurol Sci, 310, 4, 10.1016/j.jns.2011.05.027 Donaghy, 2014, Prodromal dementia with Lewy bodies, Psychol Med, 3, 1 Postuma, 2006, Potential early markers of Parkinson disease in idiopathic REM sleep behavior disorder, Neurology, 66, 845, 10.1212/01.wnl.0000203648.80727.5b Postuma, 2009, Markers of neurodegeneration in idiopathic rapid eye movement sleep behavior disorder and Parkinson disease, Brain, 132, 3298, 10.1093/brain/awp244 Iranzo, 2013, Longitudinal assessment of olfactory function in idiopathic REM sleep behavior disorder, Parkinsonism Relat Disord, 19, 600, 10.1016/j.parkreldis.2013.02.009 Frauscher, 2014, Comorbidity and medication in REM sleep behavior disorder: a multicenter case-control study, Neurology, 82, 1076, 10.1212/WNL.0000000000000247 Aguirre-Mardones, 2015, Prevalence and timeline of nonmotor symptoms in idiopathic REM sleep behavior disorder, J Neurol, 262, 1568, 10.1007/s00415-015-7742-3 Vilas, 2015, Brainstem raphe and substantia nigra echogenicity in idiopathic REM sleep behavior disorder with comorbid depression, J Neurol, 262, 1665, 10.1007/s00415-015-7745-0 Lapierre, 1992, Polysomnographic features of REM sleep behavior disorder: development of a scoring method, Neurology, 42, 1371, 10.1212/WNL.42.7.1371 Montplaisir, 2010, Polysomnographic diagnosis of idiopathic REM sleep behavior disorder, Mov Disord, 25, 2044, 10.1002/mds.23257 Frauscher, 2008, Quantification of electromyographic activity during REM sleep in multiple muscles in REM sleep behavior disorder, Sleep, 31, 724, 10.1093/sleep/31.5.724 Iranzo, 2011, Usefulness of the SINBAR electromyographic montage to detect the motor and vocal manifestations occurring in REM sleep behavior disorder, Sleep Med, 12, 284, 10.1016/j.sleep.2010.04.021 Frauscher, 2012, Normative EMG values during REM sleep for the diagnosis of REM sleep behavior disorder, Sleep, 35, 835, 10.5665/sleep.1886 Ferri, 2008, A quantitative statistical analysis of the submentalis muscle EMG amplitude during sleep in normal controls and patients with REM sleep behavior disorder, J Sleep Res, 17, 89, 10.1111/j.1365-2869.2008.00631.x Ferri, 2014, Comparison between automatic and visual scoring method of the chin muscle tone during rapid eye movement sleep, Sleep Med, 15, 661, 10.1016/j.sleep.2013.12.022 Frauscher, 2013, Defining muscle activities for assessment of rapid eye movement sleep behavior disorder: from qualitative to a quantitative diagnostic level, Sleep Med, 14, 729, 10.1016/j.sleep.2012.09.028 Manni, 2009, Motor-behavioral episodes in REM sleep behavior disorder and phasic events during REM sleep, Sleep, 32, 241, 10.1093/sleep/32.2.241 Lam, 2013, Development of scales for assessment of rapid eye movement sleep behavior disorder (RBD), Sleep Med, 14, 734, 10.1016/j.sleep.2012.09.008 Boeve, 2011, Validation of the Mayo Sleep Questionnaire to screen for REM sleep behaviour disorder in an aging and dementia cohort, Sleep Med, 12, 445, 10.1016/j.sleep.2010.12.009 Boeve, 2013, Validation of the Mayo Sleep Questionnaire to screen for REM sleep behaviour disorder in a community-based sample, J Clin Sleep Med, 9, 475, 10.5664/jcsm.2670 Postuma, 2012, A single-question screen for rapid eye movement sleep behavior disorder: a multicentre validation study, Mov Dis, 27, 913, 10.1002/mds.25037 Stiasny-Kolster, 2007, The REM sleep behavior disorder screening questionnaire–a new diagnostic instrument, Mov Dis, 22, 2386, 10.1002/mds.21740 Li, 2010, Validation of a new REM sleep behavior disorder questionnaire (RBDQ-HK), Sleep Med, 11, 43, 10.1016/j.sleep.2009.06.008 Frauscher, 2012, Validation of the Innsbruck REM sleep behavior disorder inventory, Mov Disord, 27, 1673, 10.1002/mds.25223 Nielsen, 2002, Dream-enacting behaviors in a normal population, Sleep, 32, 1629, 10.1093/sleep/32.12.1629 Iranzo, 2005, Severe obstructive sleep apnea/hypopnea syndrome mimicking REM sleep behavior disorder, Sleep, 28, 203, 10.1093/sleep/28.2.203 Oudiette, 2009, Dreamlike mentations during sleepwalking and sleep terrors in adults, Sleep, 32, 1621, 10.1093/sleep/32.12.1621 Derry, 2011, The sleep manifestations of frontal lobe epilepsy, Curr Neurol Neurosci Rep, 11, 218, 10.1007/s11910-011-0180-4 Gaig, 2012, Periodic limb movement disorder presenting as a parasomnia, J Neurol, 259, S132 Postuma, 2012, How does parkinsonism start? Prodromal parkinsonism motor changes in idiopathic REM sleep behavior disorder, Brain, 27, 617 Fantini, 2006, Olfactory deficit in idiopathic rapid eye movements sleep behavior disorder, Brain Res Bull, 70, 386, 10.1016/j.brainresbull.2006.07.008 Postuma, 2011, Olfaction and color vision identify impending neurodegeneartion in rapid eye movement sleep behavior disorder, Ann Neurol, 69, 811, 10.1002/ana.22282 Ferini-Strambi, 2004, Neuropsychological assessment in idiopathic REM sleep behavior disorder (RBD). Does the idiopathic form of RBD really exist?, Neurology, 62, 41, 10.1212/01.WNL.0000101726.69701.FA Terzaghi, 2013, Cognitive performances and mild cognitive impairment in idiopathic rapid eye movement sleep behavior disorder, Sleep, 36, 1527, 10.5665/sleep.3050 Iranzo, 2010, Decreased striatal dopamine transporter uptake and substantia nigra hyperechogenicity as risk markers of synucleinopathy in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study, Lancet Neurol, 9, 1070, 10.1016/S1474-4422(10)70216-7 Iranzo, 2011, Serial dopamine transporter imaging of nigrostriatal function in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study, Lancet Neurol, 10, 797, 10.1016/S1474-4422(11)70152-1 Iranzo, 2014, Five year follow-up of substantia nigra echogenecity in idiopathic REM sleep behavior disorder, Mov Disord, 29, 1774, 10.1002/mds.26055 Miyamoto, 2006, Reduced cardiac 123I-MIBG scintigraphy in idiopathic REM sleep behavior disorder, Neurology, 67, 2236, 10.1212/01.wnl.0000249313.25627.2e Scherfler, 2011, White and gray matter abnormalities in idiopathic REM sleep behaviour disorder. A diffusion-tensor imaging and voxel-based morphometry study, Ann Neurol, 69, 400, 10.1002/ana.22245 Sprenger, 2015, Enteric nervous system α-synuclein immunoreactivity in idiopathic REM sleep behavior disorder, Neurology, 85, 1761, 10.1212/WNL.0000000000002126 Vilas D, Iranzo A, Tolosa E, et al. In-vivo assessment of α-synuclein pathology in the submandibular glands of patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective case-control study. Lancet Neurol (in press). Uchiyama, 1999, Incidental Lewy body disease in a patient with REM sleep behaviour disorder, Neurology, 45, 709, 10.1212/WNL.45.4.709 Boeve, 2007, Insights into REM sleep behaviour disorder pathophysiology in brainstem-predominant Lewy body disease, Sleep Med, 8, 60, 10.1016/j.sleep.2006.08.017 Iranzo, 2014, Neuropathology of prodromal Lewy body disease, Mov Disord, 29, 410, 10.1002/mds.25825 Gaig, 2008, Pathological description of a non-motor variant of multiple system atrophy, J Neurol Neurosurg Psychiatry, 79, 1399, 10.1136/jnnp.2008.145276 Boeve, 2013, Clinicopathologic correlations in 172 cases of rapid eye movement sleep behavior disorder with or without a coexisting neurologic disorder, Sleep Med, 14, 754, 10.1016/j.sleep.2012.10.015 Aurora, 2010, Best practice guide for the treatment of REM sleep behavior disorder (RBD), J Clin Sleep Med, 6, 85, 10.5664/jcsm.27717 Kunz, 2013, Melatonin in rapid eye movement sleep behavior disorder: why does it work?, Sleep Med, 14, 705, 10.1016/j.sleep.2013.05.004 Kunz, 2010, A two-part, double-blind, placebo-controlled trial of exogenous melatonin in REM sleep behavior disorder, J Sleep Res, 19, 591, 10.1111/j.1365-2869.2010.00848.x McGrane, 2015, Melatonin therapy for REM sleep behaviour disorder: a critical review of evidence, Sleep Med, 16, 19, 10.1016/j.sleep.2014.09.011 Howell, 2011, A novel therapy for REM sleep behavior disorder (RBD), J Clinic Sleep Med, 7, 639, 10.5664/jcsm.1470 Carrasco, 2006, Changes in dreaming induced by CPAP in severe obstructive sleep apnea syndrome patients, J Sleep Res, 15, 430, 10.1111/j.1365-2869.2006.00553.x Vertrees, 2013, Ethical considerations in REM sleep behavior disorder, Continuum, 19, 199 Postuma, 2013, Antidepressants and REM sleep behavior disorder: isolated side effect or neurodegenerative signal?, Sleep, 36, 1579, 10.5665/sleep.3102 Schenck, 2013, Rapid eye movement sleep behavior disorder: devising controlled active treatment studies for symptomatic and neuroprotective therapy—a consensus statement from the International Rapid Eye Movement Sleep Behavior Disorder Study Group, Sleep Med, 14, 795, 10.1016/j.sleep.2013.02.016 Postuma, 2013, REM sleep behavior disorder and prodromal neurodegeneration—where are we headed?, Tremor Other Hyperkinet Mov (N Y), 3 Lang, 2013, Trials designs used to study neuroprotective therapy in Parkinson's disease, Mov Disord, 28, 86, 10.1002/mds.24997 Schapira, 2014, Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives, Lancet, 384, 545, 10.1016/S0140-6736(14)61010-2 Gagnon, 2002, REM sleep behavior disorder and REM sleep without atonia in Parkinson's disease, Neurology, 59, 585, 10.1212/WNL.59.4.585 Sixel-Döring, 2011, Associated factors for REM sleep behavior disorder in Parkinson disease, Neurology, 77, 1048, 10.1212/WNL.0b013e31822e560e Boeve, 1998, REM sleep behavior disorder and degenerative dementia. An association likely reflecting Lewy body disease, Neurology, 51, 363, 10.1212/WNL.51.2.363 Dugger, 2012, Rapid eye movement sleep behavior disorder and subtypes in autopsy-confirmed dementia with Lewy bodies, Mov Disord, 27, 72, 10.1002/mds.24003