Recombinant dioscorins of the yam storage protein expressed in Escherichia coli exhibit antioxidant and immunomodulatory activities

Hooker, 2004, Final report of the amended safety assessment of Dioscorea villosa (wild yam) root extract, Int. J. Toxicol., 23, 49, 10.1080/10915810490499055 S.C. Li, Pen-T’sao Kang Mu (Systematic Pharmacopoeia), Nanjing, China, 1596. Harvey, 1983, Isolation and characterization of the storage protein of yam tubers (Dioscorea rotundata), Phytochemistry, 22, 1687, 10.1016/S0031-9422(00)80252-6 Hou, 1999, Dioscorins, the major tuber storage proteins of yam (Dioscorea batatas Decne), with dehydroascorbate reductase and monodehydoascorbate reductase activities, Plant Sci., 149, 151, 10.1016/S0168-9452(99)00152-1 Hou, 1999, Dioscorin, the major tuber storage protein of yam (Dioscorea batatas decne) with carbonic anhydrase and trypsin inhibitor activities, J. Agric. Food Chem., 47, 2168, 10.1021/jf980738o Hou, 2000, Dioscorins from different Dioscorea species all exhibit both carbonic anhydrase and trypsin inhibitor activities, Bot. Bull. Acad. Sin., 41, 191 Hou, 2001, Antioxidant activities of dioscorin, the storage protein of yam (Dioscorea batatas Decne) tuber, J. Agric. Food Chem., 49, 4956, 10.1021/jf010606m Hsu, 2002, Both dioscorin, the tuber storage protein of yam (Dioscorea alata cv. Tainong No. 1), and its peptic hydrolysates exhibited angiotensin converting enzyme inhibitory activities, J. Agric. Food Chem., 50, 6109, 10.1021/jf0203287 Lin, 2006, Effects of tuber storage protein of yam (Dioscorea alata cv. Tainong No. 1) and its peptic hydrolyzates on spontaneously hypertensive rats, J. Sci. Food Agric., 86, 1489, 10.1002/jsfa.2530 Fu, 2006, Dioscorin isolated from Dioscorea alata activates TLR4-signaling pathways and induces cytokine expression in macrophages, Biochem. Biophys. Res. Commun., 339, 137, 10.1016/j.bbrc.2005.11.005 Liu, 2007, Immunomodulatory activity of dioscorin, the storage protein of yam (Dioscorea alata cv. Tainong No. 1) tuber, Food Chem. Toxicol., 45, 2312, 10.1016/j.fct.2007.06.009 Lin, 2009, Yam storage protein dioscorins from Dioscorea alata and Dioscorea japonica exhibit distinct immunomodulatory activities in mice, J. Agric. Food Chem., 57, 4606, 10.1021/jf8038499 Dauphinee, 2006, Lipopolysaccharide signaling in endothelial cells, Lab. Invest., 86, 9, 10.1038/labinvest.3700366 Fu, 2009, Dioscorin protects tight junction protein expression in A549 human airway epithelium cells from dust mite damage, J. Microbiol. Immunol. Infect., 42, 457 Xue, 2012, Cloning of genes and enzymatic characterizations of novel dioscorin isoforms from Dioscorea japonica, Plant Sci., 183, 14, 10.1016/j.plantsci.2011.10.021 Tsai, 2012, Molecular cloning, structural analysis, and mass spectrometric identification of native dioscorins of different species of yam tubers, J. Sci. Food Agri., 10.1002/jsfa.5789 Gaidamashvili, 2004, Characterization of the yam tuber storage proteins from Dioscorea batatas exhibiting unique lectin activities, J. Biol. Chem., 279, 26028, 10.1074/jbc.M402139200 Conlan, 1998, Characterization of the yam tuber storage protein dioscorin, J. Plant Physiol., 153, 25, 10.1016/S0176-1617(98)80040-0 Liao, 2004, Compositional and conformational analysis of yam proteins by near infrared fourier transform Raman spectroscopy, J. Agric. Food Chem., 52, 8190, 10.1021/jf049188m Huang, 2005, The chemistry behind antioxidant capacity assays, J. Agric. Food Chem., 53, 1841, 10.1021/jf030723c Liu, 2003, Patatin, the tuber storage protein of potato (Solanum tubersum L.), exhibits antioxidant activity in vitro, J. Agric. Food Chem., 51, 4389, 10.1021/jf030016j Udenigwe, 2011, Chemometric analysis of the amino acid requirements of antioxidant food protein hydrolysates, Int. J. Mol. Sci., 12, 3148, 10.3390/ijms12053148 Feng, 2009, Phenolic and enolic hydroxyl groups in curcumin: which plays the major role in scavenging radicals?, J. Agric. Food Chem., 57, 11041, 10.1021/jf902244g Sung L, 2007, Clinical applications of granulocyte-colony stimulating factor, Front Biosci., 12, 1988, 10.2741/2204 Appay, 2001, RANTES: a versatile and controversial chemokine, Trends Immunol., 22, 83, 10.1016/S1471-4906(00)01812-3 Deshmane, 2009, Monocyte Chemoattractant Protein-1 (MCP-1): an overview, J. Interferon Cytokine Res., 29, 313, 10.1089/jir.2008.0027 Kim, 2012, Mycobacterium tuberculosis Rv0652 stimulates production of TNF and MCP-1 in macrophages through the TLR4 pathway, Immunology, 10.1111/j.1365-2567.2012.03575.x Jerala, 2007, Structural biology of the LPS recognition, Int. J. Med. Microbiol., 297, 353, 10.1016/j.ijmm.2007.04.001 Muroi, 2002, The polysaccharide portion plays an indispensable role in Salmonella lipopolysaccharide-induced activation of NF-kappaB through human toll-like receptor 4, Infect. Immun., 70, 6043, 10.1128/IAI.70.11.6043-6047.2002 Ando, 2002, Safflower polysaccharides activate the transcription factor NF-kappa B via Toll-like receptor 4 and induce cytokine production by macrophages, Int. Immunopharm., 2, 1155, 10.1016/S1567-5769(02)00076-0 Lin, 2006, Reishi polysaccharides induce immunoglobulin production through the TLR4/TLR2-mediated induction of transcription factor Blimp-1, J. Biol. Chem., 281, 24111, 10.1074/jbc.M601106200 Rassa, 2002, Murine retroviruses activate B cells via interaction with toll-like receptor 4, Proc. Natl. Acad. Sci. USA, 99, 2281, 10.1073/pnas.042355399 Ohashi, 2000, Cutting Edge: Heat shock protein 60 is a putative endogenous ligand of the Toll-like receptor-4 complex, J. Immunol., 164, 558, 10.4049/jimmunol.164.2.558 Biragyn, 2002, Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin, Science, 298, 1025, 10.1126/science.1075565