Mitomycin induces alveolar epithelial cell senescence by down-regulating GSK3β signaling

Aoshiba, 2003, Bleomycin induces cellular senescence in alveolar epithelial cells, Eur. Respir. J., 22, 436, 10.1183/09031936.03.00011903 Barnes, 2019, Cellular senescence as a mechanism and target in chronic lung diseases, Am. J. Respir. Crit. Care Med., 200, 556, 10.1164/rccm.201810-1975TR Beurel, 2015, Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases, Pharmacol. Ther., 148, 114, 10.1016/j.pharmthera.2014.11.016 Byun, 2012, GSK3 inactivation is involved in mitochondrial complex IV defect in transforming growth factor (TGF) beta1-induced senescence, Exp. Cell Res., 318, 1808, 10.1016/j.yexcr.2012.04.012 Byun, 2014, PKCdelta phosphorylation is an upstream event of GSK3 inactivation-mediated ROS generation in TGF-beta1-induced senescence, Free Radic. Res., 48, 1100, 10.3109/10715762.2014.929120 Castro, 1996, A prospective study of pulmonary function in patients receiving mitomycin, Chest, 109, 939, 10.1378/chest.109.4.939 Cui, 2018, Baicalein represses TGF-beta1-induced fibroblast differentiation through the inhibition of miR-21, Toxicol. Appl. Pharmacol., 358, 35, 10.1016/j.taap.2018.09.007 Gao, 2013, Baicalein attenuates bleomycin-induced pulmonary fibrosis in rats through inhibition of miR-21, Pulm. Pharmacol. Ther., 26, 649, 10.1016/j.pupt.2013.03.006 Janeiro Pais, 2009, Pulmonary fibrosis and endovesical mitomycin C, Actas Urol. Esp., 33, 822, 10.1016/S0210-4806(09)74237-8 Jiang, 2017, Serpine 1 induces alveolar type II cell senescence through activating p53-p21-Rb pathway in fibrotic lung disease, Aging Cell, 16, 1114, 10.1111/acel.12643 Kim, 2010, Roles of GSK3 in metabolic shift toward abnormal anabolism in cell senescence, Ann. N. Y. Acad. Sci., 1201, 65, 10.1111/j.1749-6632.2010.05617.x Kulikov, 2005, Glycogen synthase kinase 3-dependent phosphorylation of Mdm2 regulates p53 abundance, Mol. Cell. Biol., 25, 7170, 10.1128/MCB.25.16.7170-7180.2005 Liu, 2020, Cell senescence and fibrotic lung diseases, Exp. Gerontol., 132, 10.1016/j.exger.2020.110836 Lu, 2020, SILAC-based proteomic profiling of the suppression of TGF-beta1-induced lung fibroblast-to-myofibroblast differentiation by trehalose, Toxicol. Appl. Pharmacol., 391, 10.1016/j.taap.2020.114916 Moumen, 2005, hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage, Cell, 123, 1065, 10.1016/j.cell.2005.09.032 Neubauer, 1987, Pulmonary fibrosis following instillation of mitomycin C in the urinary bladder, Urologe A., 26, 41 Perros, 2015, Mitomycin-induced pulmonary veno-occlusive disease: evidence from human disease and animal models, Circulation, 132, 834, 10.1161/CIRCULATIONAHA.115.014207 Qiu, 2019, PTEN loss regulates alveolar epithelial cell senescence in pulmonary fibrosis depending on Akt activation, Aging (Albany NY), 11, 7492, 10.18632/aging.102262 Rana, 2020, PAI-1 regulation of TGF-beta1-induced alveolar type II cell senescence, SASP secretion, and SASP-mediated activation of alveolar macrophages, Am. J. Respir. Cell Mol. Biol., 62, 319, 10.1165/rcmb.2019-0071OC Seo, 2008, Enhanced glycogenesis is involved in cellular senescence via GSK3/GS modulation, Aging Cell, 7, 894, 10.1111/j.1474-9726.2008.00436.x Simosato, 1971, Pulmonary lesions produced by antitumor drugs-studies on autopsy cases, Jpn. J. Can. Clin., 17, 21 Sun, 2020, Baicalein alleviated TGF beta1-induced type I collagen production in lung fibroblasts via downregulation of connective tissue growth factor, Biomed. Pharmacother., 131, 10.1016/j.biopha.2020.110744 Sun, 2020, MYH9 inhibition suppresses TGF-beta1-Stimulated lung fibroblast-to-Myofibroblast differentiation, Front. Pharmacol., 11 Tian, 2019, Loss of PTEN induces lung fibrosis via alveolar epithelial cell senescence depending on NF-kappaB activation, Aging Cell, 18, 10.1111/acel.12858 Wada, 2010, Intravesical mitomycin-C-induced interstitial pneumonia, Respiration, 80, 256, 10.1159/000280383 Wallach-Dayan, 2020, Senescence, the Janus of lung injury and repair, Am. J. Respir. Cell Mol. Biol., 62, 548, 10.1165/rcmb.2020-0022ED Zhang, 2019, Histopathological and molecular analysis of idiopathic pulmonary fibrosis lungs from patients treated with pirfenidone or nintedanib, Histopathology, 74, 341, 10.1111/his.13745 Zheng, 2020, Glycogen synthase kinase-3beta: a promising candidate in the fight against fibrosis, Theranostics, 10, 11737, 10.7150/thno.47717