Nuclear Factor-Eythroid 2–Related Factor 2 Prevents Alcohol-Induced Fulminant Liver Injury

Gastroenterology - Tập 134 - Trang 1159-1168.e2 - 2008
Jutta Lamlé1, Silke Marhenke1, Jürgen Borlak2, Reinhard von Wasielewski3, C.J. Peter Eriksson4, Robert Geffers5, Michael P. Manns1, Masayuki Yamamoto6, Arndt Vogel1
1Department of Hepatology, Gastroenterology and Endocrinology, Hannover, Germany
2Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany
3Department of Pathology, Medical School Hannover, Hannover, Germany
4Department of Mental Health and Alcohol Research, Helsinki, Finland
5Helmholtz Centre for Infection Research, Braunschweig, Germany
6Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan

Tài liệu tham khảo

Arteel, 2003, Oxidants and antioxidants in alcohol-induced liver disease, Gastroenterology, 124, 778, 10.1053/gast.2003.50087 Eriksson, 2001, The role of acetaldehyde in the actions of alcohol (update 2000), Alcohol Clin Exp Res, 25, 15S, 10.1111/j.1530-0277.2001.tb02369.x Garcia-Ruiz, 1994, Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes, J Clin Invest, 94, 193, 10.1172/JCI117306 Yin, 1999, Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice, Gastroenterology, 117, 942, 10.1016/S0016-5085(99)70354-9 Gong, 2006, Nrf2 is increased by CYP2E1 in rodent liver and HepG2 cells and protects against oxidative stress caused by CYP2E1, Hepatology, 43, 144, 10.1002/hep.21004 Moi, 1994, Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region, Proc Natl Acad Sci U S A, 91, 9926, 10.1073/pnas.91.21.9926 Chan, 2001, An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen, Proc Natl Acad Sci U S A, 98, 4611, 10.1073/pnas.081082098 Thimmulappa, 2006, Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis, J Clin Invest, 116, 984, 10.1172/JCI25790 Vogel, 2004, Chronic liver disease in murine hereditary tyrosinemia type 1 induces resistance to cell death, Hepatology, 39, 433, 10.1002/hep.20077 Vogel, 2006, Sustained phosphorylation of Bid is a marker for resistance to Fas-induced apoptosis during chronic liver diseases, Gastroenterology, 130, 104, 10.1053/j.gastro.2005.10.012 Hartmann, 2002, Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia, J Pharmacol Exp Ther, 303, 273, 10.1124/jpet.102.039404 Okawa, 2006, Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity, Biochem Biophys Res Commun, 339, 79, 10.1016/j.bbrc.2005.10.185 Eriksson, 1977, The determination of acetaldehyde in biological samples by head-space gas chromatography, Anal Biochem, 80, 116, 10.1016/0003-2697(77)90631-5 You, 2004, The role of AMP-activated protein kinase in the action of ethanol in the liver, Gastroenterology, 127, 1798, 10.1053/j.gastro.2004.09.049 Albano, 2006, Alcohol, oxidative stress and free radical damage, Proc Nutr Soc, 65, 278, 10.1079/PNS2006496 Lluis, 2003, Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress, Gastroenterology, 124, 708, 10.1053/gast.2003.50089 Zhou, 2003, A critical involvement of oxidative stress in acute alcohol-induced hepatic TNF-alpha production, Am J Pathol, 163, 1137, 10.1016/S0002-9440(10)63473-6 Kono, 2000, NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease, J Clin Invest, 106, 867, 10.1172/JCI9020 Wanless, 2004, The pathogenesis of nonalcoholic steatohepatitis and other fatty liver diseases: a four-step model including the role of lipid release and hepatic venular obstruction in the progression to cirrhosis, Semin Liver Dis, 24, 99, 10.1055/s-2004-823104 Horton, 2002, SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver, J Clin Invest, 109, 1125, 10.1172/JCI0215593 Ji, 2006, Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model, J Hepatol, 45, 717, 10.1016/j.jhep.2006.05.009 You, 2002, Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP), J Biol Chem, 277, 29342, 10.1074/jbc.M202411200 Ronis, 2005, Effects of N-acetylcysteine on ethanol-induced hepatotoxicity in rats fed via total enteral nutrition, Free Radic Biol Med, 39, 619, 10.1016/j.freeradbiomed.2005.04.011 Pastorino, 2000, Ethanol potentiates tumor necrosis factor-alpha cytotoxicity in hepatoma cells and primary rat hepatocytes by promoting induction of the mitochondrial permeability transition, Hepatology, 31, 1141, 10.1053/he.2000.7013 Colell, 1998, Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor, Gastroenterology, 115, 1541, 10.1016/S0016-5085(98)70034-4 Eferl, 2003, Liver tumor development, Cell, 112, 181, 10.1016/S0092-8674(03)00042-4 Wheeler, 2003, Up-regulation of CD14 in liver caused by acute ethanol involves oxidant-dependent AP-1 pathway, J Biol Chem, 278, 8435, 10.1074/jbc.M212076200