Visceral and mucosal involvement in neonatal haemangiomatosis

Journal of the European Academy of Dermatology and Venereology - Tập 26 Số 10 - Trang 1285-1290 - 2012
A. Maruani1,2,3, Maryam Piram4, D. Sirinelli5,3, Denis Herbreteau6,3, Élie Saliba7,3, M.C. Machet8,3, G. Lorette1,3
1Department of Dermatology, Hospital Trousseau, University Hospital Center of Tours, Avenue de la République, Tours Cedex 9, France
2INSERM U930, University Hospital Center of Tours, France
3University Francois Rabelais, Tours, France
4Department of Pediatrics, Paris XI University, Bicetre University Hospital, France
5Departments of Pediatric Radiology
6Neuroradiology,
7Neonatalogy
8Pathology

Tóm tắt

AbstractBackground  Two types of neonatal haemangiomatosis (NH) are distinguished: diffuse which is associated with a high rate of mortality linked to mucosal/visceral involvement, and benign.Objectives  First, this study aimed to examine the frequency of mucosal and visceral (especially hepatic) involvement in NH, according to skin extension, and second, it aimed to examine clinical, pathological (with glucose transporter 1 (GLUT‐1) immunostaining), and imaging features of NH, including follow‐up data.Methods  This was a descriptive retrospective study carried out in the University Hospital Center of Tours, France.Results  The study included 19 patients with cutaneous NH (number of skin haemangiomas ranging from 5 to >100). Mucosal involvement was observed in 32% of all cases (100% and 19% in diffuse and other cutaneous cases respectively) and hepatic involvement in 42% (67% and 38% respectively). The number of hepatic haemangiomas ranged from 1 to >10. Half of the hepatic haemangiomas cases exhibited increased hepatic arterial blood flow.Conclusions  Mucosal and hepatic involvement was frequent in cases with a high number of cutaneous haemangiomas (>100), but only frequency of mucosal involvement was statistically significant (P = 0.021).

Từ khóa


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Thông tin
Thông tin xuất bản

Journal of the European Academy of Dermatology and Venereology

Tập 26 Số 10

1285-1290

Thông tin tác giả