Combination therapy of pegylated interferon and lamivudine and optimal controls for chronic hepatitis B infection

International Journal of Dynamics and Control - Tập 6 - Trang 354-368 - 2017
Kalyan Manna1, Siddhartha P. Chakrabarty1
1Department of Mathematics, Indian Institute of Technology Guwahati, Guwahati, India

Tóm tắt

A model for combination therapy of pegylated interferon and lamivudine is presented in this paper. A critical drug efficacy in terms of the parameters of the model comprising of coupled ordinary differential equations is obtained. The dynamics of viral load is greatly impacted by the relation of the efficacies of the individual drugs vis-a-vis the critical efficacy. A control problem is formulated and solved numerically to obtain the optimal therapeutic regimen keeping in mind both biomedical goals and cost constraints.

Tài liệu tham khảo

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