The ins and outs of aqueous humour secretion

Avila, 2001, Reliable measurement of mouse intraocular pressure by a servo-null micropipette system, Invest. Ophthalmol. Vis. Sci., 42, 1841 Avila, 2002, Inhibitors of NHE-1 Na+/H+ exchange reduce mouse intraocular pressure, Invest. Ophthalmol. Vis. Sci., 43, 1897 Avila, 2001, A(1)-, A(2A)- and A(3)-subtype adenosine receptors modulate intraocular pressure in the mouse, Br. J. Pharmacol., 134, 241, 10.1038/sj.bjp.0704267 Avila, 2002, Knockout of A(3) adenosine receptors reduces mouse intraocular pressure, Invest. Ophthalmol. Vis. Sci., 43, 3021 Bowler, 1996, Electron probe X-ray microanalysis of rabbit ciliary epithelium, Exp. Eye Res., 62, 131, 10.1006/exer.1996.0017 Carré, 1997, Adenosine stimulates Cl− channels of nonpigmented ciliary epithelial cells, Am. J. Physiol., 273, C1354, 10.1152/ajpcell.1997.273.4.C1354 Carré, 2000, Similarity of A(3)-adenosine and swelling-activated Cl(−) channels in nonpigmented ciliary epithelial cells, Am. J. Physiol. Cell Physiol., 279, C440, 10.1152/ajpcell.2000.279.2.C440 Civan, 1983, vol. 4 Civan, 1998, Transport components of net secretion of the aqueous humor and their integrated regulation, vol. 45, 1 Civan, 1996, Regulatory volume increase of human non-pigmented ciliary epithelial cells, Exp. Eye Res., 62, 627, 10.1006/exer.1996.0074 Civan, 1997, Potential contribution of epithelial Na+ channel to net secretion of aqueous humor, J. Exp. Zool., 279, 498, 10.1002/(SICI)1097-010X(19971201)279:5<498::AID-JEZ13>3.0.CO;2-4 Coca-Prados, 1995, PKC-sensitive Cl− channels associated with ciliary epithelial homologue of pICln, Am. J. Physiol., 268, C572, 10.1152/ajpcell.1995.268.3.C572 Coca-Prados, 1998, Molecular approaches to the study of the Na+,K+-ATPase and chloride channels in the ocular ciliary epithelium, vol. 45, 25 1998, Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures, Am. J. Ophthalmol., 126, 487, 10.1016/S0002-9394(98)00223-2 1998, The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma, Am. J. Ophthalmol., 126, 498, 10.1016/S0002-9394(98)00272-4 Counillon, 2000, Na+/H+ and Cl−/HCO3-antiporters of bovine pigmented ciliary epithelial cells, Pflügers Arch., 440, 667, 10.1007/s004240000302 Crook, 2000, The role of NaKCl cotransport in blood-to-aqueous chloride fluxes across rabbit ciliary epithelium, Invest. Ophthalmol. Vis. Sci., 41, 2574 Do, C.W., Mitchell, C.H., Civan, M.M., 2003. Cyclic AMP activates maxi-Cl(−) channels in freshly dissociated bovine pigmaneted ciliary epithelial cells. In: Association for Research in Vision and Ophthalmology (ARVO) #3452. Do, 2000, Chloride secretion by bovine ciliary epithelium: a model of aqueous humor formation, Invest. Ophthalmol. Vis. Sci., 41, 1853 Dunn, 2001, Immunolocalization of the Na–K–Cl cotransporter in bovine ciliary epithelium, Invest. Ophthalmol. Vis. Sci., 42, 343 Edelman, 1994, Ion transport asymmetry and functional coupling in bovine pigmented and nonpigmented ciliary epithelial cells, Am. J. Physiol., 266, C1210, 10.1152/ajpcell.1994.266.5.C1210 Eichhorn, 1990, Regional differences in the ciliary body of cattle. An electron microscopy and histochemical study, Fortschr. Ophthalmol., 87, 241 Eichhorn, 1993, Distribution of endothelin-like immunoreactivity in the human ciliary epithelium, Curr. Eye. Res., 12, 753, 10.3109/02713689308995771 Fleischhauer, 2001, PGE(2), Ca(2+), and cAMP mediate ATP activation of Cl(−) channels in pigmented ciliary epithelial cells, Am. J. Physiol. Cell Physiol., 281, C1614, 10.1152/ajpcell.2001.281.5.C1614 Flügel, 1993, Distribution of alpha B-crystallin in the anterior segment of primate and bovine eyes, Curr. Eye Res., 12, 871, 10.3109/02713689309020393 Flügel, 1988, Presence and distribution of Na+/K+-ATPase in the ciliary epithelium of the rabbit, Histochemistry, 88, 613, 10.1007/BF00570332 Flügel, 1989, Regional differences in the morphology and enzyme distribution of the spiny dogfish (Squalus acanthias) ciliary epithelium, Exp. Eye Res., 49, 1097, 10.1016/S0014-4835(89)80029-6 Gabelt, 1997, Anterior segment physiology after bumetanide inhibition of Na–K–Cl cotransport, Invest. Ophthalmol. Vis. Sci., 38, 1700 Ghosh, 1990, Cellular distribution and differential gene expression of the three alpha subunit isoforms of the Na, K-ATPase in the ocular ciliary epithelium, J. Biol. Chem., 265, 2935, 10.1016/S0021-9258(19)39891-6 Ghosh, 1991, Expression of multiple Na+,K(+)-ATPase genes reveals a gradient of isoforms along the nonpigmented ciliary epithelium: functional implications in aqueous humor secretion, J. Cell Physiol., 149, 184, 10.1002/jcp.1041490203 Jacob, 1996, Role of ion channels in aqueous humor formation, Am. J. Physiol., 271, C703, 10.1152/ajpcell.1996.271.3.C703 Kaufman, 1994, vol. 7, 9.7 McLaughlin, C.W., Macknight, A.D.C., Civan, M.M., 2001. Effects of ouabain on ciliary epithelial cell composition. In: Abstr. Intern. Union Physiol. Sci. #651. McLaughlin, 1998, Effects of HCO3− on cell composition of rabbit ciliary epithelium: a new model for aqueous humor secretion, Invest. Ophthalmol. Vis. Sci., 39, 1631 McLaughlin, 2001, Timolol may inhibit aqueous humor secretion by cAMP-independent action on ciliary epithelial cells, Am. J. Physiol. Cell Physiol., 281, C865, 10.1152/ajpcell.2001.281.3.C865 McLaughlin, 2003, Topography of ouabain-sensitive transport across ciliary epithelium revealed by electron microprobe analysis, Ophthalmic Res., 35, 37 McLaughlin, 2001, Regional differences in ciliary epithelial cell transport properties, J. Membr. Biol., 182, 213, 10.1007/s00232-001-0045-x Mitchell, 1998, A release mechanism for stored ATP in ocular ciliary epithelial cells, Proc. Nat. Acad. Sci. USA, 95, 7174, 10.1073/pnas.95.12.7174 Mitchell, 1999, A3 adenosine receptors regulate Cl− channels of nonpigmented ciliary epithelial cells, Am. J. Physiol., 276, C659, 10.1152/ajpcell.1999.276.3.C659 Sears, 1984, Autonomic nervous system: adrenergic agonists, 193 Tamm, 1999, Development and characterization of an immortal and differentiated murine trabecular meshwork cell line, Invest. Ophthalmol. Vis. Sci., 40, 1392 2000, The advanced glaucoma intervention study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration, Am. J. Ophthalmol., 130, 429, 10.1016/S0002-9394(00)00538-9 To, 2001, Model of ionic transport for bovine ciliary epithelium: effects of acetazolamide and HCO, Am. J. Physiol. Cell Physiol., 280, C1521, 10.1152/ajpcell.2001.280.6.C1521 Wiederhielm, 1964, Pulsatile pressures in the microcirculation of a frog's mesentery, Am. J. Physiol., 207, 173, 10.1152/ajplegacy.1964.207.1.173 Wiederholt, 1991, Ion transport across the ciliary epithelium: lessons from cultured cells and proposed role of the carbonic anhydrase, 232 Wiederholt, 1986, Membrane potentials and intracellular chloride activity in the ciliary body of the shark, Pflügers Arch, 407, S112, 10.1007/BF00584939 Yantorno, 1992, Whole cell patch clamping of ciliary epithelial cells during anisosmotic swelling, Am. J. Physiol., 262, C501, 10.1152/ajpcell.1992.262.2.C501