Association of Plasmodium falciparum kelch13 R561H genotypes with delayed parasite clearance in Rwanda: an open-label, single-arm, multicentre, therapeutic efficacy study

The Lancet Infectious Diseases - Tập 21 - Trang 1120-1128 - 2021
Aline Uwimana1, Noella Umulisa2,3, Meera Venkatesan4, Samaly S Svigel5, Zhiyong Zhou5, Tharcisse Munyaneza6, Rafiki M Habimana6, Anicet Rucogoza6, Leah F Moriarty5,7, Ryan Sandford8, Emily Piercefield9, Ira Goldman5, Bryan Ezema5, Eldin Talundzic5, M Andreína Pacheco10, Ananias A Escalante10, Daniel Ngamije11, Jean-Louis N Mangala1, Michee Kabera1, Kaendi Munguti12
1Malaria and Other Parasitic Diseases Division, Rwanda Biomedical Centre, Kigali, Rwanda
2Maternal and Child Survival Program, Jhpiego, Kigali, Rwanda
3PMI Impact Malaria, Kigali, Rwanda
4US President's Malaria Initiative, US Agency for International Development, Washington, DC, USA
5Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, GA, United States
6National Reference Laboratory, Rwanda Biomedical Centre, Kigali, Rwanda
7US President's Malaria Initiative, US Centers for Disease Control and Prevention, Atlanta, GA, USA
8US Peace Corps, Kigali, Rwanda
9US President's Malaria Initiative, US Centers for Disease Control and Prevention, Kigali, Rwanda
10Biology Department, Institute of Genomics and Evolutionary Medicine, Temple University Philadelphia, PA, USA
11Ministry of Health, Kigali, Rwanda
12US President's Malaria Initiative, US Agency for International Development, Kigali, Rwanda

Tài liệu tham khảo

Uwimana, 2019, Efficacy of artemether–lumefantrine versus dihydroartemisinin–piperaquine for the treatment of uncomplicated malaria among children in Rwanda: an open-label, randomised controlled trial, Trans R Soc Trop Med Hyg, 113, 312, 10.1093/trstmh/trz009 Dondorp, 2009, Artemisinin resistance in Plasmodium falciparum malaria, N Engl J Med, 361, 455, 10.1056/NEJMoa0808859 Huang, 2012, Molecular epidemiology of drug resistance markers of Plasmodium falciparum in Yunnan Province, China, Malar J, 11, 243, 10.1186/1475-2875-11-243 Kyaw, 2013, Reduced susceptibility of Plasmodium falciparum to artesunate in southern Myanmar, PLoS One, 8, 10.1371/journal.pone.0057689 Noedl, 2008, Evidence of artemisinin-resistant malaria in western Cambodia, N Engl J Med, 359, 2619, 10.1056/NEJMc0805011 Phyo, 2012, Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study, Lancet, 379, 1960, 10.1016/S0140-6736(12)60484-X Ariey, 2014, A molecular marker of artemisinin-resistant Plasmodium falciparum malaria, Nature, 505, 50, 10.1038/nature12876 Uwimana, 2020, Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda, Nat Med, 26, 1602, 10.1038/s41591-020-1005-2 Bergmann, 2021, Increase in Kelch 13 polymorphisms in Plasmodium falciparum, southern Rwanda, Emerg Infect Dis, 27, 294, 10.3201/eid2701.203527 Tacoli, 2016, Artemisinin resistance-associated K13 polymorphisms of Plasmodium falciparum in southern Rwanda, 2010-2015, Am J Trop Med Hyg, 95, 1090, 10.4269/ajtmh.16-0483 Halsey, 2017, Capacity Development through the US President's Malaria Initiative-Supported Antimalarial Resistance Monitoring in Africa Network, Emerg Infect Dis, 23, S53 Vinayak, 2010, Multiple genetic backgrounds of the amplified Plasmodium falciparum multidrug resistance (pfmdr1) gene and selective sweep of 184F mutation in Cambodia, J Infect Dis, 201, 1551, 10.1086/651949 Talundzic, 2015, Genetic analysis and species specific amplification of the artemisinin resistance-associated Kelch propeller domain in P falciparum and P vivax, PLoS One, 10, 10.1371/journal.pone.0136099 Plucinski, 2015, Robust algorithm for systematic classification of malaria late treatment failures as recrudescence or reinfection using microsatellite genotyping, Antimicrob Agents Chemother, 59, 6096, 10.1128/AAC.00072-15 Talundzic, 2015, Selection and spread of artemisinin-resistant alleles in Thailand prior to the global artemisinin resistance containment campaign, PLoS Pathog, 11 Nei, 1973, Analysis of gene diversity in subdivided populations, Proc Natl Acad Sci USA, 70, 3321, 10.1073/pnas.70.12.3321 McCollum, 2008, Hitchhiking and selective sweeps of Plasmodium falciparum sulfadoxine and pyrimethamine resistance alleles in a population from central Africa, Antimicrob Agents Chemother, 52, 4089, 10.1128/AAC.00623-08 Stepniewska, 2010, In vivo parasitological measures of artemisinin susceptibility, J Infect Dis, 201, 570, 10.1086/650301 Asua, 2020, Changing prevalence of potential mediators of aminoquinoline, antifolate, and artemisinin resistance across Uganda, J Infect Dis Bwire, 2020, Detection of mutations associated with artemisinin resistance at k13-propeller gene and a near complete return of chloroquine susceptible falciparum malaria in southeast of Tanzania, Sci Rep, 10, 10.1038/s41598-020-60549-7 Chenet, 2016, Independent emergence of the Plasmodium falciparum Kelch propeller domain mutant allele C580Y in Guyana, J Infect Dis, 213, 1472, 10.1093/infdis/jiv752 Wootton, 2002, Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum, Nature, 418, 320, 10.1038/nature00813 Vinayak, 2010, Origin and evolution of sulfadoxine resistant Plasmodium falciparum, PLoS Pathog, 6, 10.1371/journal.ppat.1000830 Ocan, 2018, bK13-propeller gene polymorphisms in Plasmodium falciparum parasite population: a systematic review protocol of burden and associated factors, Syst Rev, 7, 199, 10.1186/s13643-018-0866-7 Venkatesan, 2014, Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine, Am J Trop Med Hyg, 91, 833, 10.4269/ajtmh.14-0031 Zeile, 2012, Molecular markers of Plasmodium falciparum drug resistance in southern highland Rwanda, Acta Trop, 121, 50, 10.1016/j.actatropica.2011.09.009 Woodrow, 2017, The clinical impact of artemisinin resistance in southeast Asia and the potential for future spread, FEMS Microbiol Rev, 41, 34, 10.1093/femsre/fuw037