Abnormal fibrils from scrapie-infected brain

Springer Science and Business Media LLC - Tập 54 - Trang 63-74 - 1981
P. A. Merz1, R. A. Somerville1, H. M. Wisniewski1, K. Iqbal1
1New York State Institute for Basic Research in Mental Retardation, Staten Island, USA

Tóm tắt

Abnormal fibrillary structures, designated “scrapie-associated fibrils” (SAF), have been observed using negative stain techniques in subfractions of brains from scrapie-affected animals. SAF have been observed in all combinations of strain of scrapie agent and strain or species of host examined, regardless of their histopathology, in particular the presence or absence of amyloid plaques. SAF consist either of two or four filaments. They are morphologically dissimilar to the normal brain fibrils — microtubules, neurofilaments, glial filaments, and F actin. However, SAF do bear a resemblance to amyloid.

Tài liệu tham khảo

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