Efficient and reproducible mammalian cell bioprocesses without probes and controllers?

Muller, 2005, Orbital shaker technology for the cultivation of mammalian cells in suspension, Biotechnol. Bioeng., 89, 400, 10.1002/bit.20358 Stettler, 2007, Novel orbital shake bioreactors for transient production of CHO derived IgGs, Biotechnol. Prog., 23, 1340, 10.1021/bp070219i Zhang, 2009, Use of orbital shaken disposable bioreactors for mammalian cell cultures from the milliliter-scale to the 1,000-liter scale, Adv. Biochem. Eng. Biotechnol., 1 Lara, 2006, Living with heterogeneities in bioreactors: understanding the effects of environmental gradients on cells, Mol. Biotechnol., 34, 355, 10.1385/MB:34:3:355 Zlokarnik, 2003, Stirring Tissot, 2010, Determination of a scale-up factor from mixing time studies in orbitally shaken bioreactors, Biochem. Eng. J., 52, 181, 10.1016/j.bej.2010.08.005 Xing, 2009, Scale-up analysis for a CHO cell culture process in large-scale bioreactors, Biotechnol. Bioeng., 103, 733, 10.1002/bit.22287 Zhang, 2009, Efficient oxygen transfer by surface aeration in shaken cylindrical containers for mammalian cell cultivation at volumetric scales up to 1000L, Biochem. Eng. J., 45, 41, 10.1016/j.bej.2009.02.003 Bonvillani, 2006, Theoretical and experimental study of the effects of scale-up on mixing time for a stirred-tank bioreactor, Braz. J. Chem. Eng., 23, 1, 10.1590/S0104-66322006000100001 Garcia-Ochoa, 2009, Bioreactor scale-up and oxygen transfer rate in microbial processes: an overview, Biotechnol. Adv., 27, 153, 10.1016/j.biotechadv.2008.10.006 Marks, 2003, Equipment design considerations for large scale cell culture, Cytotechnology, 42, 21, 10.1023/A:1026103405618 Marques, 2010, Bioprocess scale-up: quest for the parameters to be used as criterion tomove from microreactors to lab-scale, J. Chem. Technol. Biotechnol., 85, 1184, 10.1002/jctb.2387 Chu, 2001, Industrial choices for protein production by large-scale cell culture, Curr. Opin. Biotechnol., 12, 180, 10.1016/S0958-1669(00)00197-X Nienow, 2006, Reactor engineering in large scale animal cell culture, Cytotechnology, 50, 9, 10.1007/s10616-006-9005-8 Merten, 2006, Introduction to animal cell culture technology – past, present and future, Cytotechnology, 50, 1, 10.1007/s10616-006-9009-4 Langer, 2008 Melton, 2002, DISMT – determination of mixing time through color changes, Chem. Eng. Commun., 189, 322, 10.1080/00986440212077 Gupta, 2003, A study of oxygen transfer in shake flasks using a non-invasive oxygen sensor, Biotechnol. Bioeng., 84, 351, 10.1002/bit.10740 Sumino, 1972, Performance of the shaking flask. I. Power consumption, J. Ferment. Technol., 50, 203 Büchs, 2000, Power consumption in shaking flasks on rotary shaking machines: I. Power consumption measurement in unbaffled flasks at low liquid viscosity, Biotechnol. Bioeng., 68, 589, 10.1002/(SICI)1097-0290(20000620)68:6<589::AID-BIT1>3.0.CO;2-J Kato, 2004, Power consumption and heat transfer resistance in large rotary shaking vessels, Biochem. Eng. J., 21, 83, 10.1016/j.bej.2004.04.011 Oberbek, 2011, Generation of stable, high-producing CHO cell lines by lentiviral vector-mediated gene transfer in serum-free suspension culture, Biotechnol. Bioeng., 108, 600, 10.1002/bit.22968 Zhang, 2006, New disposable tubes for rapid and precise biomass assessment for suspension cultures of mammalian cells, Biotechnol. Bioeng., 95, 1228, 10.1002/bit.21071 Meissner, 2001, Transient gene expression: recombinant protein production with suspension-adapted HEK293-EBNA cells, Biotechnol. Bioeng., 75, 197, 10.1002/bit.1179 Ma, 2002, Fabrication and use of a transient contractional flow device to quantify the sensitivity of mammalian and insect cells to hydrodynamic forces, Biotechnol. Bioeng., 80, 428, 10.1002/bit.10387 Mollet, 2004, Bioprocess equipment: characterization of energy dissipation rate and its potential to damage cells, Biotechnol. Prog., 20, 1437, 10.1021/bp0498488 Melville, 1996, The role of surface-wave breaking in air–sea interaction, Annu. Rev. Fluid Mech., 28, 279, 10.1146/annurev.fl.28.010196.001431 Doblhoff-Dier, 1999, Quality control and assurance from the development to the production of biopharmaceuticals, Trends Biotechnol., 17, 266, 10.1016/S0167-7799(99)01314-1