Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases
Tài liệu tham khảo
Abdou, 2008, Evaluation of survivin and NF-kappaB in psoriasis, an immunohistochemical study, J Cutan Pathol, 35, 445, 10.1111/j.1600-0560.2007.00841.x
Abe, 1999, Curcumin inhibition of inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages, Pharmacol Res, 39, 41, 10.1006/phrs.1998.0404
Aggarwal, 2003, Signalling pathways of the TNF superfamily: a double-edged sword, Nat Rev Immunol, 3, 745, 10.1038/nri1184
Aggarwal, 2004, Nuclear factor-kappaB: the enemy within, Cancer Cell, 6, 203, 10.1016/j.ccr.2004.09.003
Aggarwal, 1985, Characterization of receptors for human tumour necrosis factor and their regulation by gamma-interferon, Nature, 318, 665, 10.1038/318665a0
Aggarwal, 1985, Human tumor necrosis factor. Production, purification, and characterization, J Biol Chem, 260, 2345, 10.1016/S0021-9258(18)89560-6
Aggarwal, 2007, Targeting cell signaling pathways for drug discovery: an old lock needs a new key, J Cell Biochem, 102, 580, 10.1002/jcb.21500
Aggarwal, 2006, Inflammation and cancer: how hot is the link?, Biochem Pharmacol, 72, 1605, 10.1016/j.bcp.2006.06.029
Aggarwal, 2005, Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice, Clin Cancer Res, 11, 7490, 10.1158/1078-0432.CCR-05-1192
Aggarwal, 2006, TNF blockade: an inflammatory issue, Ernst Schering Res Found Workshop, 161
Aggarwal, 2006, Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation, Mol Pharmacol, 69, 195, 10.1124/mol.105.017400
Aggarwal, 2004, Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling, Int J Cancer, 111, 679, 10.1002/ijc.20333
Ahn, 2005, Transcription factor NF-kappaB: a sensor for smoke and stress signals, Ann N Y Acad Sci, 1056, 218, 10.1196/annals.1352.026
Al-Omar, 2006, Immediate and delayed treatments with curcumin prevents forebrain ischemia-induced neuronal damage and oxidative insult in the rat hippocampus, Neurochem Res, 31, 611, 10.1007/s11064-006-9059-1
Anand, 2007, Bioavailability of curcumin: problems and promises, Mol Pharm, 4, 807, 10.1021/mp700113r
Anand, 2008, Curcumin and cancer: an “old-age” disease with an “age-old” solution, Cancer Lett, 10.1016/j.canlet.2008.03.025
Annaert, 2002, A cell biological perspective on Alzheimer's disease, Annu Rev Cell Dev Biol, 18, 25, 10.1146/annurev.cellbio.18.020402.142302
Ansell, 2007, Targeting the anti-inflammatory effects of high-density lipoprotein, Am J Cardiol, 100, n3, 10.1016/j.amjcard.2007.08.006
Aoki, 2007, Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways, Mol Pharmacol, 72, 29, 10.1124/mol.106.033167
Arun, 2002, Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats, Plant Foods Hum Nutr, 57, 41, 10.1023/A:1013106527829
Atamna, 2006, Amyloid-beta peptide binds with heme to form a peroxidase: relationship to the cytopathologies of Alzheimer's disease, Proc Natl Acad Sci USA, 103, 3381, 10.1073/pnas.0600134103
Atwood, 2004, Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta, Biochemistry, 43, 560, 10.1021/bi0358824
Babu, 1995, Influence of dietary curcumin and cholesterol on the progression of experimentally induced diabetes in albino rat, Mol Cell Biochem, 152, 13, 10.1007/BF01076459
Babu, 1997, Hypolipidemic action of curcumin, the active principle of turmeric (Curcuma longa) in streptozotocin induced diabetic rats, Mol Cell Biochem, 166, 169, 10.1023/A:1006819605211
Balasubramanyam, 2004, Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription, J Biol Chem, 279, 51163, 10.1074/jbc.M409024200
Banerjee, 2003, Modulation of inflammatory mediators by ibuprofen and curcumin treatment during chronic inflammation in rat, Immunopharmacol Immunotoxicol, 25, 213, 10.1081/IPH-120020471
Barthelemy, 1998, Curcumin and curcumin derivatives inhibit Tat-mediated transactivation of type 1 human immunodeficiency virus long terminal repeat, Res Virol, 149, 43, 10.1016/S0923-2516(97)86899-9
Baum, 2008, Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease, J Clin Psychopharmacol, 28, 110, 10.1097/jcp.0b013e318160862c
Baum, 2004, Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models, J Alzheimers Dis, 6, 367, 10.3233/JAD-2004-6403
Bayrak, 2008, Curcumin protects against ischemia/reperfusion injury in rat kidneys, World J Urol, 26, 285, 10.1007/s00345-008-0253-4
Best, 2007, Curcumin induces electrical activity in rat pancreatic beta-cells by activating the volume-regulated anion channel, Biochem Pharmacol, 73, 1768, 10.1016/j.bcp.2007.02.006
Bharti, 2003, Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells, J Immunol, 171, 3863, 10.4049/jimmunol.171.7.3863
Bharti, 2003, Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis, Blood, 101, 1053, 10.1182/blood-2002-05-1320
Billerey-Larmonier, 2008, Protective effects of dietary curcumin in mouse model of chemically induced colitis are strain dependent, Inflamm Bowel Dis, 14, 780, 10.1002/ibd.20348
Bishnoi, 2008, Protective effect of curcumin, the active principle of turmeric (Curcuma longa) in haloperidol-induced orofacial dyskinesia and associated behavioural, biochemical and neurochemical changes in rat brain, Pharmacol Biochem Behav, 88, 511, 10.1016/j.pbb.2007.10.009
Bisht, 2007, Polymeric nanoparticle-encapsulated curcumin (“nanocurcumin”): a novel strategy for human cancer therapy, J Nanobiotechnol, 5, 3, 10.1186/1477-3155-5-3
Biswas, 2008, Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin, Mol Nutr Food Res, 10.1002/mnfr.200700259
Calabrese, 2003, Redox regulation of heat shock protein expression in aging and neurodegenerative disorders associated with oxidative stress: a nutritional approach, Amino Acids, 25, 437, 10.1007/s00726-003-0048-2
Chen, 2008, Cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for osteoarthritis and rheumatoid arthritis: a systematic review and economic evaluation, Health Technol Assess, 12, 1, 10.3310/hta12110
Chen, 2008, C-reactive protein increases plasminogen activator inhibitor-1 expression in human endothelial cells, Thromb Res, 122, 125, 10.1016/j.thromres.2007.09.006
Cheng, 2001, Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions, Anticancer Res, 21, 2895
Cruz-Correa, 2006, Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis, Clin Gastroenterol Hepatol, 4, 1035, 10.1016/j.cgh.2006.03.020
Danese, 2008, Inflammatory bowel disease and inflammation-associated colon cancer: partners in crime, Curr Drug Targets, 9, 360, 10.2174/138945008784221134
Dantzer, 2008, From inflammation to sickness and depression: when the immune system subjugates the brain, Nat Rev Neurosci, 9, 46, 10.1038/nrn2297
Davis, 2007, Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage, Am J Physiol Regul Integr Comp Physiol, 292, R2168, 10.1152/ajpregu.00858.2006
Deeb, 2007, Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1-6-heptadine-3,5-dione; C21H20O6] sensitizes human prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L-induced apoptosis by suppressing nuclear factor-kappaB via inhibition of the prosurvival Akt signaling pathway, J Pharmacol Exp Ther, 321, 616, 10.1124/jpet.106.117721
Deguchi, 2007, Curcumin prevents the development of dextran sulfate Sodium (DSS)-induced experimental colitis, Dig Dis Sci, 52, 2993, 10.1007/s10620-006-9138-9
Deodhar, 1980, Preliminary study on antirheumatic activity of curcumin (diferuloyl methane), Indian J Med Res, 71, 632
Dhillon, 2008, Phase II trial of curcumin, an NF-κB inhibitor, in patients with advanced pancreatic cancer, Clin Cancer Res, 14, 4491, 10.1158/1078-0432.CCR-08-0024
Fahey, 2007, Curcumin modulation of IFN-beta and IL-12 signalling and cytokine induction in human T cells, J Cell Mol Med, 11, 1129, 10.1111/j.1582-4934.2007.00089.x
Farhangkhoee, 2006, Differential effects of curcumin on vasoactive factors in the diabetic rat heart, Nutr Metab (Lond), 3, 27, 10.1186/1743-7075-3-27
Feng, 2008, Regulation of cardiomyocyte hypertrophy in diabetes at the transcriptional level, Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00029.2008
Fiala, 2007, Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin, Proc Natl Acad Sci USA, 104, 12849, 10.1073/pnas.0701267104
Funk, 2006, Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis, J Nat Prod, 69, 351, 10.1021/np050327j
Garcia-Alloza, 2007, Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model, J Neurochem, 102, 1095, 10.1111/j.1471-4159.2007.04613.x
Garodia, 2007, From ancient medicine to modern medicine: ayurvedic concepts of health and their role in inflammation and cancer, J Soc Integr Oncol, 5, 25, 10.2310/7200.2006.029
Ghoneim, 2002, Protective effects of curcumin against ischaemia/reperfusion insult in rat forebrain, Pharmacol Res, 46, 273, 10.1016/S1043-6618(02)00123-8
Goel, 2008, Curcumin as “Curecumin”: from kitchen to clinic, Biochem Pharmacol, 75, 787, 10.1016/j.bcp.2007.08.016
Hafner-Bratkovic, 2008, Curcumin binds to the alpha-helical intermediate and to the amyloid form of prion protein—a new mechanism for the inhibition of PrP(Sc) accumulation, J Neurochem, 104, 1553, 10.1111/j.1471-4159.2007.05105.x
Haidara, 2006, Role of oxidative stress in development of cardiovascular complications in diabetes mellitus, Curr Vasc Pharmacol, 4, 215, 10.2174/157016106777698469
Hak, 2008, Lifestyle and gout, Curr Opin Rheumatol, 20, 179, 10.1097/BOR.0b013e3282f524a2
Hansson, 2006, Inflammation and atherosclerosis, Annu Rev Pathol, 1, 297, 10.1146/annurev.pathol.1.110304.100100
Heng, 2000, Drug-induced suppression of phosphorylase kinase activity correlates with resolution of psoriasis as assessed by clinical, histological and immunohistochemical parameters, Br J Dermatol, 143, 937, 10.1046/j.1365-2133.2000.03767.x
Hold, 2008, Genetic aspects of inflammation and cancer, Biochem J, 410, 225, 10.1042/BJ20071341
Holt, 2005, Curcumin therapy in inflammatory bowel disease: a pilot study, Dig Dis Sci, 50, 2191, 10.1007/s10620-005-3032-8
Hong, 2004, Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase, Carcinogenesis, 25, 1671, 10.1093/carcin/bgh165
Huang, 2004, Redox-active metals, oxidative stress, and Alzheimer's disease pathology, Ann N Y Acad Sci, 1012, 153, 10.1196/annals.1306.012
Jackson, 2006, The antioxidants curcumin and quercetin inhibit inflammatory processes associated with arthritis, Inflamm Res, 55, 168, 10.1007/s00011-006-0067-z
Jagetia, 2007, “Spicing up” of the immune system by curcumin, J Clin Immunol, 27, 19, 10.1007/s10875-006-9066-7
Jain, 2006, Effect of curcumin on protein glycosylation, lipid peroxidation, and oxygen radical generation in human red blood cells exposed to high glucose levels, Free Radic Biol Med, 41, 92, 10.1016/j.freeradbiomed.2006.03.008
Jess, 2005, Increased risk of intestinal cancer in Crohn's disease: a meta-analysis of population-based cohort studies, Am J Gastroenterol, 100, 2724, 10.1111/j.1572-0241.2005.00287.x
Jian, 2005, Preventive and therapeutic effects of NF-kappaB inhibitor curcumin in rats colitis induced by trinitrobenzene sulfonic acid, World J Gastroenterol, 11, 1747, 10.3748/wjg.v11.i12.1747
Jiang, 2007, Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood-brain barrier damage, Eur J Pharmacol, 561, 54, 10.1016/j.ejphar.2006.12.028
Joe, 1997, Presence of an acidic glycoprotein in the serum of arthritic rats: modulation by capsaicin and curcumin, Mol Cell Biochem, 169, 125, 10.1023/A:1006877928703
Jones, 2000, The effect of mycophenolate mofetil and polyphenolic bioflavonoids on renal ischemia reperfusion injury and repair, J Urol, 163, 999, 10.1016/S0022-5347(05)67871-8
Ju, 1996, Effects of dietary fats and curcumin on IgE-mediated degranulation of intestinal mast cells in brown Norway rats, Biosci Biotechnol Biochem, 60, 1856, 10.1271/bbb.60.1856
Kamat, 2007, Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cancer cells, Mol Cancer Ther, 6, 1022, 10.1158/1535-7163.MCT-06-0545
Kanitkar, 2008, Curcumin treatment enhances islet recovery by induction of heat shock response proteins, Hsp70 and heme oxygenase-1, during cryopreservation, Life Sci, 82, 182, 10.1016/j.lfs.2007.10.026
Karin, 2005, NF-kappaB: linking inflammation and immunity to cancer development and progression, Nat Rev Immunol, 5, 749, 10.1038/nri1703
Kawanami, 2006, C-reactive protein induces VCAM-1 gene expression through NF-kappaB activation in vascular endothelial cells, Atherosclerosis, 185, 39, 10.1016/j.atherosclerosis.2005.01.057
Kean, 2005, The use of NSAIDs in rheumatic disorders 2005: a global perspective, Inflammopharmacology, 13, 343, 10.1163/156856005774415565
Khanna, 2007, Natural products as a gold mine for arthritis treatment, Curr Opin Pharmacol, 7, 344, 10.1016/j.coph.2007.03.002
Kim, 2001, Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from betaA(1-42) insult, Neurosci Lett, 303, 57, 10.1016/S0304-3940(01)01677-9
Kobayashi, 1997, Curcumin inhibition of Dermatophagoides farinea-induced interleukin-5 (IL-5) and granulocyte macrophage-colony stimulating factor (GM-CSF) production by lymphocytes from bronchial asthmatics, Biochem Pharmacol, 54, 819, 10.1016/S0006-2952(97)00220-7
Kowluru, 2007, Oxidative stress and diabetic retinopathy, Exp Diabetes Res, 2007, 43603, 10.1155/2007/43603
Kowluru, 2007, Effects of curcumin on retinal oxidative stress and inflammation in diabetes, Nutr Metab (Lond), 4, 8, 10.1186/1743-7075-4-8
Kuhad, 2007, Curcumin attenuates diabetic encephalopathy in rats: behavioral and biochemical evidences, Eur J Pharmacol, 576, 34, 10.1016/j.ejphar.2007.08.001
Kumar, 2004, Nuclear factor-kappaB: its role in health and disease, J Mol Med, 82, 434, 10.1007/s00109-004-0555-y
Kumar, 2005, Elevated expression of alphaA- and alphaB-crystallins in streptozotocin-induced diabetic rat, Arch Biochem Biophys, 444, 77, 10.1016/j.abb.2005.09.021
Kunnumakkara, 2008, Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins, Cancer Lett, 10.1016/j.canlet.2008.03.009
Kunnumakkara, 2007, Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products, Cancer Res, 67, 3853, 10.1158/0008-5472.CAN-06-4257
Kurd, 2008, Oral curcumin in the treatment of moderate to severe psoriasis vulgaris: a prospective clinical trial, J Am Acad Dermatol, 58, 625, 10.1016/j.jaad.2007.12.035
Kuroda, 2005, Hypoglycemic effects of turmeric (Curcuma longa L. rhizomes) on genetically diabetic KK-Ay mice, Biol Pharm Bull, 28, 937, 10.1248/bpb.28.937
Kurup, 2008, Immunomodulatory effects of curcumin in allergy, Mol Nutr Food Res, 10.1002/mnfr.200700293
Kurup, 2007, Immune response modulation by curcumin in a latex allergy model, Clin Mol Allergy, 5, 1, 10.1186/1476-7961-5-1
Lao, 2006, Dose escalation of a curcuminoid formulation, BMC Complement Altern Med, 6, 10, 10.1186/1472-6882-6-10
Lev-Ari, 2006, Curcumin synergistically potentiates the growth-inhibitory and pro-apoptotic effects of celecoxib in osteoarthritis synovial adherent cells, Rheumatology (Oxford), 45, 171, 10.1093/rheumatology/kei132
Li, 2004, Gout: a review of its aetiology and treatment, Hong Kong Med J, 10, 261
Li, 2008, Curcumin prevents and reverses murine cardiac hypertrophy, J Clin Invest, 118, 879
Li, 2004, Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis, Cancer, 101, 2351, 10.1002/cncr.20605
Li, 2005, Liposome-encapsulated curcumin: in vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis, Cancer, 104, 1322, 10.1002/cncr.21300
Liacini, 2003, Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes, Exp Cell Res, 288, 208, 10.1016/S0014-4827(03)00180-0
Libby, 2007, Inflammatory mechanisms: the molecular basis of inflammation and disease, Nutr Rev, 65, S140, 10.1301/nr.2007.dec.S140-S146
Lim, 2001, The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse, J Neurosci, 21, 8370, 10.1523/JNEUROSCI.21-21-08370.2001
Lin, 2007, Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-kappaB pathway, Clin Cancer Res, 13, 3423, 10.1158/1078-0432.CCR-06-3072
Liote, 2007, Recent developments in crystal-induced inflammation pathogenesis and management, Curr Rheumatol Rep, 9, 243, 10.1007/s11926-007-0039-5
Liu, 2006, Immunohistochemical localization of activated Stat3 and hTERT protein in psoriasis vulgaris, Eur J Dermatol, 16, 205
Lopez-Lazaro, 2008, Anticancer and carcinogenic properties of curcumin: considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent, Mol Nutr Food Res, 10.1002/mnfr.200700238
Mach, 2005, Inflammation is a crucial feature of atherosclerosis and a potential target to reduce cardiovascular events, Handb Exp Pharmacol, 697, 10.1007/3-540-27661-0_26
Mahesh, 2004, Photo-irradiated curcumin supplementation in streptozotocin-induced diabetic rats: effect on lipid peroxidation, Therapie, 59, 639, 10.2515/therapie:2004110
Maiti, 2007, Curcumin-phospholipid complex: preparation, therapeutic evaluation and pharmacokinetic study in rats, Int J Pharm, 330, 155, 10.1016/j.ijpharm.2006.09.025
Manikandan, 2004, Curcumin modulates free radical quenching in myocardial ischaemia in rats, Int J Biochem Cell Biol, 36, 1967, 10.1016/j.biocel.2004.01.030
Marczylo, 2007, Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine, Cancer Chemother Pharmacol, 60, 171, 10.1007/s00280-006-0355-x
Marwick, 2007, Oxidative stress and steroid resistance in asthma and COPD: pharmacological manipulation of HDAC-2 as a therapeutic strategy, Expert Opin Ther Targets, 11, 745, 10.1517/14728222.11.6.745
Mazumder, 1995, Inhibition of human immunodeficiency virus type-1 integrase by curcumin, Biochem Pharmacol, 49, 1165, 10.1016/0006-2952(95)98514-A
McCormick, 2007, Role of oxidative stress in the pathogenesis of abdominal aortic aneurysms, Arterioscler Thromb Vasc Biol, 27, 461, 10.1161/01.ATV.0000257552.94483.14
Meghana, 2007, Curcumin prevents streptozotocin-induced islet damage by scavenging free radicals: a prophylactic and protective role, Eur J Pharmacol, 577, 183, 10.1016/j.ejphar.2007.09.002
Moller, 2003, Role of PPARs in the regulation of obesity-related insulin sensitivity and inflammation, Int J Obes Relat Metab Disord, 27, S17, 10.1038/sj.ijo.0802494
Morimoto, 2008, The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats, J Clin Invest, 118, 868
Mrudula, 2007, Effect of curcumin on hyperglycemia-induced vascular endothelial growth factor expression in streptozotocin-induced diabetic rat retina, Biochem Biophys Res Commun, 361, 528, 10.1016/j.bbrc.2007.07.059
Murugan, 2005, Effect of tetrahydrocurcumin on erythromycin estolate-induced lipid peroxidation in rats, J Basic Clin Physiol Pharmacol, 16, 1, 10.1515/JBCPP.2005.16.1.1
Murugan, 2006, Effect of tetrahydrocurcumin on lipid peroxidation and lipids in streptozotocin-nicotinamide-induced diabetic rats, Basic Clin Pharmacol Toxicol, 99, 122, 10.1111/j.1742-7843.2006.pto_447.x
Murugan, 2007, Influence of tetrahydrocurcumin on erythrocyte membrane bound enzymes and antioxidant status in experimental type 2 diabetic rats, J Ethnopharmacol, 113, 479, 10.1016/j.jep.2007.07.004
Murugan, 2007, Influence of tetrahydrocurcumin on hepatic and renal functional markers and protein levels in experimental type 2 diabetic rats, Basic Clin Pharmacol Toxicol, 101, 241, 10.1111/j.1742-7843.2007.00109.x
Mythri, 2007, Mitochondrial complex I inhibition in Parkinson's disease: how can curcumin protect mitochondria?, Antioxid Redox Signal, 9, 399, 10.1089/ars.2006.1479
Natarajan, 2002, Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase-STAT pathway in T lymphocytes, J Immunol, 168, 6506, 10.4049/jimmunol.168.12.6506
Nirmala, 1996, Effect of curcumin on certain lysosomal hydrolases in isoproterenol-induced myocardial infarction in rats, Biochem Pharmacol, 51, 47, 10.1016/0006-2952(95)02118-3
Nirmala, 1996, Protective role of curcumin against isoproterenol induced myocardial infarction in rats, Mol Cell Biochem, 159, 85, 10.1007/BF00420910
Nishiyama, 2005, Curcuminoids and sesquiterpenoids in turmeric (Curcuma longa L.) suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice, J Agric Food Chem, 53, 959, 10.1021/jf0483873
NTP (1993). NTP Toxicology and Carcinogenesis Studies of Turmeric Oleoresin (CAS No. 8024-37-1) (Major Component 79–85% Curcumin, CAS No. 458-37-7) in F344/N Rats and B6C3F1 Mice (Feed Studies). Natl Toxicol Program Tech Rep Ser, 427, 1–275.
Odrowaz-Sypniewska, 2007, Markers of pro-inflammatory and pro-thrombotic state in the diagnosis of metabolic syndrome, Adv Med Sci, 52, 246
Olszanecki, 2005, Effect of curcumin on atherosclerosis in apoE/LDLR-double knockout mice, J Physiol Pharmacol, 56, 627
Ono, 2004, Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro, J Neurosci Res, 75, 742, 10.1002/jnr.20025
Onodera, 2000, Macrophage migration inhibitory factor up-regulates expression of matrix metalloproteinases in synovial fibroblasts of rheumatoid arthritis, J Biol Chem, 275, 444, 10.1074/jbc.275.1.444
Packard, 2008, Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction, Clin Chem, 54, 24, 10.1373/clinchem.2007.097360
Pan, 2007, In vitro studies of platelet adhesion, activation, and protein adsorption on curcumin-eluting biodegradable stent materials, J Biomed Mater Res A, 82, 740, 10.1002/jbm.a.31108
Pan, 2007, Improved blood compatibility of rapamycin-eluting stent by incorporating curcumin, Colloids Surf B Biointerfaces, 59, 105, 10.1016/j.colsurfb.2007.04.015
Pari, 2007, Antihyperlipidemic effect of curcumin and tetrahydrocurcumin in experimental type 2 diabetic rats, Ren Fail, 29, 881, 10.1080/08860220701540326
Pari, 2007, Tetrahydrocurcumin prevents brain lipid peroxidation in streptozotocin-induced diabetic rats, J Med Food, 10, 323, 10.1089/jmf.2006.058
Park, 2007, Curcumin induces apoptosis and inhibits prostaglandin E(2) production in synovial fibroblasts of patients with rheumatoid arthritis, Int J Mol Med, 20, 365
Parodi, 2006, Oral administration of diferuloylmethane (curcumin) suppresses proinflammatory cytokines and destructive connective tissue remodeling in experimental abdominal aortic aneurysms, Ann Vasc Surg, 20, 360, 10.1007/s10016-006-9054-7
Patumraj, 2006, Combined effects of curcumin and vitamin C to protect endothelial dysfunction in the iris tissue of STZ-induced diabetic rats, Clin Hemorheol Microcirc, 35, 481
Pillarisetti, 2004, Role of oxidative stress and inflammation in the origin of Type 2 diabetes—a paradigm shift, Expert Opin Ther Targets, 8, 401, 10.1517/14728222.8.5.401
Pol, 2003, Comparison of antiproliferative effects of experimental and established antipsoriatic drugs on human keratinocytes, using a simple 96-well-plate assay, In Vitro Cell Dev Biol Anim, 39, 36, 10.1290/1543-706X(2003)039<0036:COAEOE>2.0.CO;2
Pugazhenthi, 2007, Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells, Am J Physiol Endocrinol Metab, 293, E645, 10.1152/ajpendo.00111.2007
Punithavathi, 2000, Curcumin inhibition of bleomycin-induced pulmonary fibrosis in rats, Br J Pharmacol, 131, 169, 10.1038/sj.bjp.0703578
Quiles, 1998, An ethanolic-aqueous extract of Curcuma longa decreases the susceptibility of liver microsomes and mitochondria to lipid peroxidation in atherosclerotic rabbits, Biofactors, 8, 51, 10.1002/biof.5520080110
Quiles, 2002, Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits, Arterioscler Thromb Vasc Biol, 22, 1225, 10.1161/01.ATV.0000020676.11586.F2
Ram, 2003, Curcumin attenuates allergen-induced airway hyperresponsiveness in sensitized guinea pigs, Biol Pharm Bull, 26, 1021, 10.1248/bpb.26.1021
Ramaswami, 2004, Curcumin blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries, J Vasc Surg, 40, 1216, 10.1016/j.jvs.2004.09.021
Ramirez Boscá, 2000, An hydroalcoholic extract of Curcuma longa lowers the abnormally high values of human-plasma fibrinogen, Mech Ageing Dev, 114, 207, 10.1016/S0047-6374(00)00089-0
Ramirez-Tortosa, 1999, Oral administration of a turmeric extract inhibits LDL oxidation and has hypocholesterolemic effects in rabbits with experimental atherosclerosis, Atherosclerosis, 147, 371, 10.1016/S0021-9150(99)00207-5
Rao, 1970, Effect of curcumin on serum and liver cholesterol levels in the rat, J Nutr, 100, 1307, 10.1093/jn/100.11.1307
Rathore, 2007, Curcuma Oil: Reduces Early Accumulation of Oxidative Product and is Anti-apoptogenic in Transient Focal Ischemia in Rat Brain, Neurochem Res
Riva, 2008, Two immunomodulators, curcumin and sulfasalazine, enhance IDV antiretroviral activity in HIV-1 persistently infected cells, Arch Virol, 153, 561, 10.1007/s00705-007-0023-4
Robinson, 2007, Inflammation, obesity, and fatty acid metabolism: influence of n-3 polyunsaturated fatty acids on factors contributing to metabolic syndrome, Appl Physiol Nutr Metab, 32, 1008, 10.1139/H07-087
Rodriguez-Bores, 2007, Basic and clinical aspects of osteoporosis in inflammatory bowel disease, World J Gastroenterol, 13, 6156, 10.3748/wjg.13.6156
Sajithlal, 1998, Effect of curcumin on the advanced glycation and cross-linking of collagen in diabetic rats, Biochem Pharmacol, 56, 1607, 10.1016/S0006-2952(98)00237-8
Sale, 2008, The relationship between disease symptoms, life events, coping and treatment, and depression among older adults with osteoarthritis, J Rheumatol, 35, 335
Salh, 2003, Curcumin attenuates DNB-induced murine colitis, Am J Physiol Gastrointest Liver Physiol, 285, G235, 10.1152/ajpgi.00449.2002
Sandur, 2007, Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane), Free Radic Biol Med, 43, 568, 10.1016/j.freeradbiomed.2007.05.009
Sandur, 2007, Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism, Carcinogenesis, 28, 1765, 10.1093/carcin/bgm123
Sano, 2005, Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model, Nat Med, 11, 43, 10.1038/nm1162
Schlesinger, 2006, Colchicine for acute gout, Cochrane Database Syst Rev, 10.1002/14651858.CD006190
Selmi, 2007, Inflammation and oxidative stress in obstructive sleep apnea syndrome, Exp Biol Med (Maywood), 232, 1409, 10.3181/0704-MR-103
Sethi, 2008, Nuclear factor-kappaB activation: from bench to bedside, Exp Biol Med (Maywood), 233, 21, 10.3181/0707-MR-196
Shahed, 2001, Quercetin and curcumin up-regulate antioxidant gene expression in rat kidney after ureteral obstruction or ischemia/reperfusion injury, Transplant Proc, 33, 2988, 10.1016/S0041-1345(01)02283-7
Shakibaei, 2005, Curcumin protects human chondrocytes from IL-l1beta-induced inhibition of collagen type II and beta1-integrin expression and activation of caspase-3: an immunomorphological study, Ann Anat, 187, 487, 10.1016/j.aanat.2005.06.007
Sharma, 2004, Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance, Clin Cancer Res, 10, 6847, 10.1158/1078-0432.CCR-04-0744
Sharma, 2007, Pharmacokinetics and pharmacodynamics of curcumin, Adv Exp Med Biol, 595, 453, 10.1007/978-0-387-46401-5_20
Sharma, 2007, Effect of insulin and its combination with resveratrol or curcumin in attenuation of diabetic neuropathic pain: participation of nitric oxide and TNF-alpha, Phytother Res, 21, 278, 10.1002/ptr.2070
Sharma, 2006, Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain, Eur J Pharmacol, 536, 256, 10.1016/j.ejphar.2006.03.006
Sharma, 2006, Curcumin, the active principle of turmeric (Curcuma longa), ameliorates diabetic nephropathy in rats, Clin Exp Pharmacol Physiol, 33, 940, 10.1111/j.1440-1681.2006.04468.x
Shishodia, 2005, Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma, Biochem Pharmacol, 70, 700, 10.1016/j.bcp.2005.04.043
Shoba, 1998, Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers, Planta Med, 64, 353, 10.1055/s-2006-957450
Shoskes, 1998, Effect of bioflavonoids quercetin and curcumin on ischemic renal injury: a new class of renoprotective agents, Transplantation, 66, 147, 10.1097/00007890-199807270-00001
Shoskes, 2000, Synergy of mycophenolate mofetil and bioflavonoids in prevention of immune and ischemic injury, Transplant Proc, 32, 798, 10.1016/S0041-1345(00)00987-8
Sidhu, 1999, Curcumin enhances wound healing in streptozotocin induced diabetic rats and genetically diabetic mice, Wound Repair Regen, 7, 362, 10.1046/j.1524-475X.1999.00362.x
Sidhu, 1998, Enhancement of wound healing by curcumin in animals, Wound Repair Regen, 6, 167, 10.1046/j.1524-475X.1998.60211.x
Singh, 1995, Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected], J Biol Chem, 270, 24995, 10.1074/jbc.270.42.24995
Siwak, 2005, Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway, Cancer, 104, 879, 10.1002/cncr.21216
Skommer, 2007, Gene-expression profiling during curcumin-induced apoptosis reveals downregulation of CXCR4, Exp Hematol, 35, 84, 10.1016/j.exphem.2006.09.006
Smith, 2007, The redox chemistry of the Alzheimer's disease amyloid beta peptide, Biochim Biophys Acta, 1768, 1976, 10.1016/j.bbamem.2007.02.002
Smolen, 2008, The burden of rheumatoid arthritis and access to treatment: a medical overview, Eur J Health Econ, 8, S39, 10.1007/s10198-007-0087-9
Smolen, 2008, Strengths and limitations of a systematic review on DMARDs for rheumatoid arthritis, Nat Clin Pract Rheumatol, 10.1038/ncprheum0813
Sng, 2006, Histone modifications in kainate-induced status epilepticus, Eur J Neurosci, 23, 1269, 10.1111/j.1460-9568.2006.04641.x
Somasundaram, 2002, Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer, Cancer Res, 62, 3868
South, 1997, Dietary curcumin enhances antibody response in rats, Immunopharmacol Immunotoxicol, 19, 105, 10.3109/08923979709038536
Srinivasan, 1972, Effect of curcumin on blood sugar as seen in a diabetic subject, Indian J Med Sci, 26, 269
Srivastava, 1985, Anti-thrombotic effect of curcumin, Thromb Res, 40, 413, 10.1016/0049-3848(85)90276-2
Sumanont, 2006, Prevention of kainic acid-induced changes in nitric oxide level and neuronal cell damage in the rat hippocampus by manganese complexes of curcumin and diacetylcurcumin, Life Sci, 78, 1884, 10.1016/j.lfs.2005.08.028
Suryanarayana, 2005, Curcumin and turmeric delay streptozotocin-induced diabetic cataract in rats, Invest Ophthalmol Vis Sci, 46, 2092, 10.1167/iovs.04-1304
Suryanarayana, 2007, Effect of turmeric and curcumin on oxidative stress and antioxidant enzymes in streptozotocin-induced diabetic rat, Med Sci Monit, 13, BR286
Suzuki, 2005, Elucidation of anti-allergic activities of curcumin-related compounds with a special reference to their anti-oxidative activities, Biol Pharm Bull, 28, 1438, 10.1248/bpb.28.1438
Tergaonkar, 2006, NFkappaB pathway: a good signaling paradigm and therapeutic target, Int J Biochem Cell Biol, 38, 1647, 10.1016/j.biocel.2006.03.023
Thaloor, 1999, Systemic administration of the NF-kappaB inhibitor curcumin stimulates muscle regeneration after traumatic injury, Am J Physiol, 277, C320, 10.1152/ajpcell.1999.277.2.C320
Thiyagarajan, 2004, Neuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral ischemia in rats, Life Sci, 74, 969, 10.1016/j.lfs.2003.06.042
Thresiamma, 1996, Protective effect of curcumin, ellagic acid and bixin on radiation induced toxicity, Indian J Exp Biol, 34, 845
Tikoo, 2008, Change in post-translational modifications of histone H3, heat-shock protein-27 and MAP kinase p38 expression by curcumin in streptozotocin-induced type I diabetic nephropathy, Br J Pharmacol, 153, 1225, 10.1038/sj.bjp.0707666
Tonnesen, 1987, Studies on curcumin and curcuminoids. IX. Investigation of the photobiological activity of curcumin using bacterial indicator systems, J Pharm Sci, 76, 371, 10.1002/jps.2600760506
Tourkina, 2004, Curcumin-induced apoptosis in scleroderma lung fibroblasts: role of protein kinase cepsilon, Am J Respir Cell Mol Biol, 31, 28, 10.1165/rcmb.2003-0354OC
Tschape, 2006, Therapeutic perspectives in Alzheimer's disease, Recent Patents CNS Drug Discov, 1, 119, 10.2174/157488906775245354
Ukil, 2003, Curcumin, the major component of food flavour turmeric, reduces mucosal injury in trinitrobenzene sulphonic acid-induced colitis, Br J Pharmacol, 139, 209, 10.1038/sj.bjp.0705241
Uno, 2006, The role of tumor necrosis factor alpha in down-regulation of osteoblast Phex gene expression in experimental murine colitis, Gastroenterology, 131, 497, 10.1053/j.gastro.2006.05.020
Vadhan Raj, 2007, Curcumin downregulates NF-κB and related genes in patients with multiple myeloma: results of a phase1/2 study, American Society of Hematology
Vajragupta, 2005, Active site binding modes of curcumin in HIV-1 protease and integrase, Bioorg Med Chem Lett, 15, 3364, 10.1016/j.bmcl.2005.05.032
Vamvouris, 2006, A review of the treatment of psoriasis with infliximab, Rev Recent Clin Trials, 1, 201, 10.2174/157488706778250122
Vazquez, 2007, Comparison of body mass index, waist circumference, and waist/hip ratio in predicting incident diabetes: a meta-analysis, Epidemiol Rev, 29, 115, 10.1093/epirev/mxm008
Venkatesan, 1998, Curcumin attenuation of acute adriamycin myocardial toxicity in rats, Br J Pharmacol, 124, 425, 10.1038/sj.bjp.0701877
Venkataranganna, 2007, NCB-02 (standardized Curcumin preparation) protects dinitrochlorobenzene- induced colitis through down-regulation of NF-κB and iNOS, World J Gastroenterol, 13, 1103, 10.3748/wjg.v13.i7.1103
Verbeek, 2005, Oral flavonoids delay recovery from experimental autoimmune encephalomyelitis in SJL mice, Biochem Pharmacol, 70, 220, 10.1016/j.bcp.2005.04.041
Vlietinck, 1998, Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection, Planta Med, 64, 97, 10.1055/s-2006-957384
Wahlstrom, 1978, A study on the fate of curcumin in the rat, Acta Pharmacol Toxicol (Copenh), 43, 86, 10.1111/j.1600-0773.1978.tb02240.x
Wang, 2005, Neuroprotective mechanisms of curcumin against cerebral ischemia-induced neuronal apoptosis and behavioral deficits, J Neurosci Res, 82, 138, 10.1002/jnr.20610
Wang, 2008, The antidepressant effects of curcumin in the forced swimming test involve 5-HT1 and 5-HT2 receptors, Eur J Pharmacol, 578, 43, 10.1016/j.ejphar.2007.08.045
Weisberg, 2008, Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity, Endocrinology, 10.1210/en.2008-0262
Wuyts, 2003, Involvement of p38 MAPK, JNK, p42/p44 ERK and NF-κB in IL-1β-induced chemokine release in human airway smooth muscle cells, Respir Med, 97, 811, 10.1016/S0954-6111(03)00036-2
Xu, 2007, Effects of curcumin in treatment of experimental pulmonary fibrosis: a comparison with hydrocortisone, J Ethnopharmacol, 112, 292, 10.1016/j.jep.2007.03.011
Xu, 2005, The effects of curcumin on depressive-like behaviors in mice, Eur J Pharmacol, 518, 40, 10.1016/j.ejphar.2005.06.002
Yang, 2005, Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo, J Biol Chem, 280, 5892, 10.1074/jbc.M404751200
Yang, 2006, Curcumin inhibits platelet-derived growth factor-stimulated vascular smooth muscle cell function and injury-induced neointima formation, Arterioscler Thromb Vasc Biol, 26, 85, 10.1161/01.ATV.0000191635.00744.b6
Yeh, 2005, Inhibition of NFkappaB activation with curcumin attenuates plasma inflammatory cytokines surge and cardiomyocytic apoptosis following cardiac ischemia/reperfusion, J Surg Res, 125, 109, 10.1016/j.jss.2004.11.009
Yeh, 2005, Inhibition of NF-κB activation can attenuate ischemia/reperfusion-induced contractility impairment via decreasing cardiomyocytic proinflammatory gene up-regulation and matrix metalloproteinase expression, J Cardiovasc Pharmacol, 45, 301, 10.1097/01.fjc.0000155385.41479.b3
Zbarsky, 2005, Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease, Free Radic Res, 39, 1119, 10.1080/10715760500233113
Zhang, 2006, Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer's disease patients, J Alzheimers Dis, 10, 1, 10.3233/JAD-2006-10101