Granular Cell Tumor Breast Masquerading as a Malignancy Cytologically: a Rare Case Presenting a Diagnostic Dilemma

Springer Science and Business Media LLC - Tập 11 - Trang 321-324 - 2020
Mukta Pujani1, Kanika Singh1, Sujata Raychaudhuri1, Charu Agarwal1, Aparna Khandelwal1, Reetika Menia1, Devender Prajapati2
1Department of Pathology, ESIC Medical College, Faridabad, India
2Department of Surgery, ESIC Medical College, Faridabad, India

Tóm tắt

Granular cell tumor (GCT) also known as Abrikossoff’s tumor is an uncommon soft tissue tumor of neurogenic origin. GCT of the breast accounts for < 0.1% of breast tumors and 6% of all reported cases of granular cell tumor. Although GCT is a benign tumor, malignant GCT can be seen in 1% v of the cases. GCT of the breast is diagnostically challenging as it can imitate carcinoma clinically and radiologically but need to be differentiated from breast malignancy since they have totally different approach in treatment and prognosis. GCT has a great ability to mimic a variety of lesions from benign histiocytic to malignant epithelial/mesenchymal lesions, thereby presenting a diagnostic challenge to the practicing cytopathologist. We report a case of GCT of breast cytologically masquerading as a malignancy in a 45-year-old female. Although, fine needle aspiration (FNA) is a first-line diagnostic tool, the present case reemphasizes the role of histopathology as the gold standard for a definite diagnosis clubbed with ancillary techniques like immunohistochemistry and special stains.

Tài liệu tham khảo

Adeniran A, Al-Ahmadie H, Mahoney MC, Robinson-Smith TM (2004) Granular cell tumor of the breast: a series of 17 cases and review of the literature. Breast J 10:528–531 Brown AC, Audisio RA, Regitnig P (2011) Granular cell tumour of the breast. Surg Oncol 20:97–105 Abrikossoff A (1926) Über myome, ausgehend von der quergestreiften willkürlichen muskulatur. Virchow Arch 260:215–233 Haikal F, Maceira J, Dias E, Ramos-E-Silva M (2010) Histogenesis of Abrikossoff tumour of the oral cavity. Int J Dent Hyg 8(1):53–62 Aoyama K, Kamio T, Hirano A, Seshimo A, Kameoka S (2012) Granular cell tumors: a report of six cases. World J Surg Oncol 10:204 Schrader KA, Nelson TN, De Luca A, Huntsman DG, BC MG (2009) Multiple granular cell tumors are an associated feature of LEOPARD syndrome caused by mutation in PTPN11. Clin Genet 75(2):185–189 Becelli R, Perugini M, Gasparini G, Cassoni A, Fabiani F (2001) Abrikossoff’s tumor. J Craniofac Surg 12:78–81 Vasselli F, Pediconi F, Luciani ML, Casali V, Telesca M, Miglio E et al (2011) Breast localization of granular cell tumor (GCT). Euro Rad Khurana U, Handa U, Mohan H (2016) Fine-needle aspiration cytology of cutaneous granular cell tumor: report of two cases with special emphasis on cytological differential diagnosis. J Cytol 33:30–33 Koshy J, Schnadig V, Nawgiri R (2014) Is fine needle aspiration cytology a useful diagnostic tool for granular cell tumors? A cytohistological review with emphasis on pitfalls. Cytojournal 11:28 Fanburg-Smith JC, Meis-Kindblom JM, Fante R, Kindblom LG (1998) Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol 22:779–794