Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine

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Abstract nr 4372 Tate SC, Cai S, Ajamie RT, Burke T, Beckmann RP, Chan EM, et al (2014)Semi-mechanistic Pharmacokinetic/Pharmacodynamic Modeling of the Anti-Tumor Activity of LY2835219, a New Cyclin-Dependent Kinase 4/6 Inhibitor, in Mice Bearing Human Tumor Xenografts. Clin Can Res doi:10.1158/1078-0432.CCR-13-2846 Shapiro G, Rosen LS, Tolcher, AW, Goldman JW, Gandhi L, Papadopoulos KP, et al A first-in-human phase I study o fthe CDK4/6 inhibitor, LY2835219, for patients with advanced cancer. J Clin Oncol 31, 2013 (Suppl; abstr 2500). Patnaik A, Rosen LS, Tolaney SM, Tolcher AW, Goldman JW, Gandhi L, et al Clinical activity of LY2835219, a novel cell cycle inhibitor selective for CDK4 and CDK6, in patients with metastatic breast cancer [abstract]. AACR 2014 Apr 7; Abstr CT-232. Kim KT, Baird K, Ahn JY, Meltzer P, Lilly M, Levis M et al (2005) Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival. 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