The FAI protein of group C streptococci acts as a mucosal adjuvant by the specific targeting and activation of B cells

Bajpai, 2000, Bruton's tyrosine kinase links the B cell receptor to nuclear factor kappaB activation, J. Exp. Med., 191, 1735, 10.1084/jem.191.10.1735 Bruton, 1952, Agammaglobulinemia, Pediatrics, 9, 722, 10.1542/peds.9.6.722 Czerkinsky, 1996, Cholera toxin B subunit as transmucosal carrier-delivery and immunomodulating system for induction of antiinfectious and antipathological immunity, Ann. NY Acad. Sci., 778, 185, 10.1111/j.1749-6632.1996.tb21127.x Dupuis, 1998, Dendritic cells internalize vaccine adjuvant after intramuscular injection, Cell. Immunol., 186, 18, 10.1006/cimm.1998.1283 Freund, 1937, Sensitization and antibody formation after injection of tubercle bacilli and paraffin oil, Proc. Soc. Exp. Biol. Med., 37, 509, 10.3181/00379727-37-9625 Fujihashi, 2002, A dilemma for mucosal vaccination: efficacy versus toxicity using enterotoxin-based adjuvants, Vaccine, 20, 2431, 10.1016/S0264-410X(02)00155-X Giuliani, 1998, Mucosal adjuvanticity and immunogenicity of LTR72, a novel mutant of Escherichia coli heat-labile enterotoxin with partial knockout of ADP-ribosyltransferase activity, J. Exp. Med., 187, 1123, 10.1084/jem.187.7.1123 Goto, 1993, Studies on the toxicities of aluminium hydroxide and calcium phosphate as immunological adjuvants for vaccines, Vaccine, 11, 914, 10.1016/0264-410X(93)90377-A Medina, 1998, Fibronectin-binding protein I of Streptococcus pyogenes is a promising adjuvant for antigens delivered by mucosal route, Eur. J. Immunol., 28, 1069, 10.1002/(SICI)1521-4141(199803)28:03<1069::AID-IMMU1069>3.0.CO;2-P Mutsch, 2004, Use of the inactivated intranasal influenza vaccine and the risk of Bell's palsy in Switzerland, N. Engl. J. Med., 350, 896, 10.1056/NEJMoa030595 Okemoto, 2006, A potent adjuvant monophosphoryl lipid A triggers various immune responses, but not secretion of IL-1beta or activation of caspase-1, J. Immunol., 176, 1203, 10.4049/jimmunol.176.2.1203 Rawlings, 1993, Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice, Science, 261, 358, 10.1126/science.8332901 Schneerson, 1991, Evaluation of monophosphoryl lipid A (MPL) as an adjuvant. Enhancement of the serum antibody response in mice to polysaccharide-protein conjugates by concurrent injection with MPL, J. Immunol., 147, 2136, 10.4049/jimmunol.147.7.2136 Schulze, 2003, Identification of the domains of the fibronectin-binding protein I of Streptococcus pyogenes responsible for adjuvanticity, FEMS Immunol. Med. Microbiol., 37, 173, 10.1016/S0928-8244(03)00071-3 Schulze, 2005, The FAI protein of group C streptococci targets B cells and exhibits adjuvant activity, Vaccine, 23, 1408, 10.1016/j.vaccine.2004.08.045 Schulze, 2006, Intranasal vaccination with SfbI or M protein-derived peptides conjugated to diphtheria toxoid confers protective immunity against a lethal challenge with Streptococcus pyogenes, Vaccine, 24, 6088, 10.1016/j.vaccine.2006.05.024 Straw, 1985, Comparison of tissue reactions produced by Haemophilus pleuropneumoniae vaccines made with six different adjuvants in swine, Can. J. Comp. Med., 49, 149 Talay, 1996, Structure of a group C streptococcal protein that binds to fibrinogen, albumin and immunoglobulin G via overlapping modules, Biochem. J., 315, 577, 10.1042/bj3150577 van Ginkel, 2000, Cutting edge: the mucosal adjuvant cholera toxin redirects vaccine proteins into olfactory tissues, J. Immunol., 165, 4778, 10.4049/jimmunol.165.9.4778 Yamamoto, 1997, Mutants in the ADP-ribosyltransferase cleft of cholera toxin lack diarrheagenicity but retain adjuvanticity, J. Exp. Med., 185, 1203, 10.1084/jem.185.7.1203