In vivo tissue cholesterol efflux is reduced in carriers of a mutation in APOA1

Gordon, 1989, High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies, Circulation., 79, 8, 10.1161/01.CIR.79.1.8 Assmann, 1996, High-density lipoprotein cholesterol as a predictor of coronary heart disease risk. The PROCAM experience and pathophysiological implications for reverse cholesterol transport, Atherosclerosis., 124, S11, 10.1016/0021-9150(96)05852-2 deGoma, 2008, Beyond high-density lipoprotein cholesterol levels evaluating high-density lipoprotein function as influenced by novel therapeutic approaches, J. Am. Coll. Cardiol., 51, 2199, 10.1016/j.jacc.2008.03.016 Barter, 2007, HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events, N. Engl. J. Med., 357, 1301, 10.1056/NEJMoa064278 Briel, 2009, Association between change in high density lipoprotein cholesterol and cardiovascular disease morbidity and mortality: systematic review and meta-regression analysis, BMJ., 338, b92, 10.1136/bmj.b92 Vergeer, 2010, The HDL hypothesis: does high-density lipoprotein protect from atherosclerosis?, J. Lipid Res., 51, 2058, 10.1194/jlr.R001610 Tall, 2008, Cholesterol efflux pathways and other potential mechanisms involved in the athero-protective effect of high density lipoproteins, J. Intern. Med., 263, 256, 10.1111/j.1365-2796.2007.01898.x Kuivenhoven, 1997, The molecular pathology of lecithin:cholesterol acyltransferase (LCAT) deficiency syndromes, J. Lipid Res., 38, 191, 10.1016/S0022-2275(20)37433-2 Hobbs, 1999, ABC1: connecting yellow tonsils, neuropathy, and very low HDL, J. Clin. Invest., 104, 1015, 10.1172/JCI8509 Alam, 2001, Effect of up-regulating individual steps in the reverse cholesterol transport pathway on reverse cholesterol transport in normolipidemic mice, J. Biol. Chem., 276, 15641, 10.1074/jbc.M010230200 Groen, 2001, Hepatobiliary cholesterol transport is not impaired in Abca1-null mice lacking HDL, J. Clin. Invest., 108, 843, 10.1172/JCI200112473 Xie, 2009, ABCA1 plays no role in the centripetal movement of cholesterol from peripheral tissues to the liver and intestine in the mouse, J. Lipid Res., 50, 1316, 10.1194/jlr.M900024-JLR200 Jolley, 1998, Centripetal cholesterol flux to the liver is dictated by events in the peripheral organs and not by the plasma high density lipoprotein or apolipoprotein A-I concentration, J. Lipid Res., 39, 2143, 10.1016/S0022-2275(20)32469-X Singaraja, 2002, Increased ABCA1 activity protects against atherosclerosis, J. Clin. Invest., 110, 35, 10.1172/JCI0215748 Harchaoui, 2009, Reduced fecal sterol excretion in subjects with familial hypoalphalipoproteinemia, Atherosclerosis., 207, 614, 10.1016/j.atherosclerosis.2009.06.022 Eriksson, 1999, Stimulation of fecal steroid excretion after infusion of recombinant proapolipoprotein A-I. Potential reverse cholesterol transport in humans, Circulation., 100, 594, 10.1161/01.CIR.100.6.594 Nanjee, 2001, Intravenous apoA-I/lecithin discs increase pre-beta-HDL concentration in tissue fluid and stimulate reverse cholesterol transport in humans, J. Lipid Res., 42, 1586, 10.1016/S0022-2275(20)32212-4 Turner, 2012, Measurement of reverse cholesterol transport pathways in humans: in vivo rates of free cholesterol efflux, esterification, and excretion, J. Am. Heart Assoc., 1, e001826, 10.1161/JAHA.112.001826 Hovingh, 2004, A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease, J. Am. Coll. Cardiol., 44, 1429, 10.1016/j.jacc.2004.06.070 Neese, 1993, Measurement of endogenous synthesis of plasma cholesterol in rats and humans using MIDA, Am. J. Physiol., 264, E136 Goodman, 1980, Prediction of the parameters of whole body cholesterol metabolism in humans, J. Lipid Res., 21, 699, 10.1016/S0022-2275(20)34798-2 Grundy, 1969, Measurements of cholesterol turnover, synthesis, and absorption in man, carried out by isotope kinetic and sterol balance methods, J. Lipid Res., 10, 91, 10.1016/S0022-2275(20)42653-7 Goodman, 1973, The effects of colestipol resin and of colestipol plus clofibrate on the turnover of plasma cholesterol in man, J. Clin. Invest., 52, 2646, 10.1172/JCI107457 Schwartz, 1982, Multicompartmental analysis of cholesterol metabolism in man. Quantitative kinetic evaluation of precursor sources and turnover of high density lipoprotein cholesterol esters, J. Clin. Invest., 70, 863, 10.1172/JCI110683 Schwartz, 2004, Lipoprotein cholesteryl ester production, transfer, and output in vivo in humans, J. Lipid Res., 45, 1594, 10.1194/jlr.M300511-JLR200 Schwartz, 1982, Central role of high density lipoprotein in plasma free cholesterol metabolism, J. Clin. Invest., 70, 105, 10.1172/JCI110582 Schwartz, 1993, Cholesterol kinetics in subjects with bile fistula. Positive relationship between size of the bile acid precursor pool and bile acid synthetic rate, J. Clin. Invest., 91, 923, 10.1172/JCI116314 Amar, 2010, 5A apolipoprotein mimetic peptide promotes cholesterol efflux and reduces atherosclerosis in mice, J. Pharmacol. Exp. Ther., 334, 634, 10.1124/jpet.110.167890 Moore, 2005, Increased atherosclerosis in mice lacking apolipoprotein A-I attributable to both impaired reverse cholesterol transport and increased inflammation, Circ. Res., 97, 763, 10.1161/01.RES.0000185320.82962.F7 von Eckardstein, 1995, Reverse cholesterol transport in plasma of patients with different forms of familial HDL deficiency, Arterioscler. Thromb. Vasc. Biol., 15, 691, 10.1161/01.ATV.15.5.691 Miccoli, 1997, A natural apolipoprotein A-I variant, apoA-I (L141R)Pisa, interferes with the formation of alpha-high density lipoproteins (HDL) but not with the formation of pre beta 1-HDL and influences efflux of cholesterol into plasma, J. Lipid Res., 38, 1242, 10.1016/S0022-2275(20)37205-9 Calpe-Berdiel, 2005, Direct evidence in vivo of impaired macrophage-specific reverse cholesterol transport in ATP-binding cassette transporter A1-deficient mice, Biochim. Biophys. Acta., 1738, 6, 10.1016/j.bbalip.2005.11.012 Osono, 1996, Centripetal cholesterol flux from extrahepatic organs to the liver is independent of the concentration of high density lipoprotein-cholesterol in plasma, Proc. Natl. Acad. Sci. USA., 93, 4114, 10.1073/pnas.93.9.4114 Wang, 2004, ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins, Proc. Natl. Acad. Sci. USA., 101, 9774, 10.1073/pnas.0403506101 Kennedy, 2005, ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation, Cell Metab., 1, 121, 10.1016/j.cmet.2005.01.002 Liu, 1993, Activation of plasma lysolecithin acyltransferase reaction by apolipoproteins A-I, C-I and E, Biochim. Biophys. Acta., 1168, 144, 10.1016/0005-2760(93)90118-S Glomset, 1968, The plasma lecithins:cholesterol acyltransferase reaction, J. Lipid Res., 9, 155, 10.1016/S0022-2275(20)43114-1 Koukos, 2007, LCAT can rescue the abnormal phenotype produced by the natural ApoA-I mutations (Leu141Arg)Pisa and (Leu159Arg)FIN, Biochemistry., 46, 10713, 10.1021/bi7003203 Ouguerram, 2002, A new labeling approach using stable isotopes to study in vivo plasma cholesterol metabolism in humans, Metabolism., 51, 5, 10.1053/meta.2002.29006 Plump, 1997, ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes, J. Lipid Res., 38, 1033, 10.1016/S0022-2275(20)37227-8 Beher, 1983, Effect of blood high density lipoprotein cholesterol concentration on fecal steroid excretion in humans, Life Sci., 32, 2933, 10.1016/0024-3205(83)90643-4 Gylling, 1992, Non-cholesterol sterols, absorption and synthesis of cholesterol and apolipoprotein A-I kinetics in a Finnish lecithin-cholesterol acyltransferase deficient family, Atherosclerosis., 95, 25, 10.1016/0021-9150(92)90172-D Miettinen, 1989, Cholesterol absorption: regulation of cholesterol synthesis and elimination and within-population variations of serum cholesterol levels, Am. J. Clin. Nutr., 49, 629, 10.1093/ajcn/49.4.629 Drobnik, 2001, ATP-binding cassette transporter A1 (ABCA1) affects total body sterol metabolism, Gastroenterology., 120, 1203, 10.1053/gast.2001.23250 Brousseau, 2005, Effects of cholesteryl ester transfer protein inhibition on high-density lipoprotein subspecies, apolipoprotein A-I metabolism, and fecal sterol excretion, Arterioscler. Thromb. Vasc. Biol., 25, 1057, 10.1161/01.ATV.0000161928.16334.dd van der Velde, 2007, Direct intestinal cholesterol secretion contributes significantly to total fecal neutral sterol excretion in mice, Gastroenterology., 133, 967, 10.1053/j.gastro.2007.06.019 van der Veen, 2009, Activation of the liver X receptor stimulates trans-intestinal excretion of plasma cholesterol, J. Biol. Chem., 284, 19211, 10.1074/jbc.M109.014860 Simmonds, 1967, Absorption of cholesterol from a micellar solution: intestinal perfusion studies in man, J. Clin. Invest., 46, 874, 10.1172/JCI105587 Jakulj, L., Stroes, E., Groen, A. K., . 2012. TICE: a novel pathway for whole-body cholesterol excretion (Abstract 270 in 16th International Symposium on Atherosclerosis. Sydney, Australia, March 25–29, 2012). Smith, 1976, Parameters of the three-pool model of the turnover of plasma cholesterol in normal and hyperlipidemic humans, J. Clin. Invest., 57, 137, 10.1172/JCI108253