Effective encapsulation and biological activity of phosphorylated chemotherapeutics in calcium phosphosilicate nanoparticles for the treatment of pancreatic cancer

Nanomedicine: Nanotechnology, Biology and Medicine - Tập 13 - Trang 2313-2324 - 2017
Welley S. Loc1,2, Samuel S. Linton3, Zachary R. Wilczynski4, Gail L. Matters5, Christopher O. McGovern5, Thomas Abraham6, Todd Fox7, Christopher M. Gigliotti4, Xiaomeng Tang1,2, Amra Tabakovic2, Jo Ann Martin8, Gary A. Clawson9, Jill P. Smith10, Peter J. Butler4, Mark Kester7, James H. Adair2,3,4
1Department of Chemistry, Pennsylvania State University, University Park, PA, USA
2Department of Materials Science and Engineering, Pennsylvania State University, University Park, PA, USA
3Department of Pharmacology, Pennsylvania State University, College of Medicine, Hershey, PA, USA
4Department of Biomedical Engineering/Bioengineering, Pennsylvania State University, University Park, PA, USA
5Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, PA, USA
6Department of Neural and Behavioral Sciences and the Microscopy Imaging Facility, Pennsylvania State University College of Medicine, Hershey, PA, USA
7Department of Pharmacology, University of Virginia, Charlottesville, Va. USA
8Biomedical Engineering, University of Florida, Gainesville, FL, USA
9Department of Pathology and Gittlen Cancer Institute, Pennsylvania State University College of Medicine, Hershey, PA, USA
10Department of Medicine, Georgetown University, Washington, DC, USA

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