Mephedrone (‘bath salt’) elicits conditioned place preference and dopamine-sensitive motor activation

Angoa-Pérez, 2012, Mephedrone, an abused psychoactive component of ‘bath salts’ and methamphetamine congener, does not cause neurotoxicity to dopamine nerve endings of the striatum, J. Neurochem., 120, 1097 Al-Motarreb, 2010, Khat chewing, cardiovascular diseases and other internal medical problems: the current situation and directions for future research, J. Ethnopharmacol., 132, 540, 10.1016/j.jep.2010.07.001 Ball, 2003, Acute effects of 3,4-methylenedioxymethamphetamine on striatal single-unit activity and behavior in freely moving rats: differential involvement of dopamine D(1) and D(2) receptors, Brain Res., 994, 203, 10.1016/j.brainres.2003.09.037 Ball, 2011, Behavioral sensitization to 3,4-methylenedioxymethamphetamine is long-lasting and modulated by the context of drug administration, Behav. Pharmacol., 22, 847, 10.1097/FBP.0b013e32834d13b4 Baumann, 2012, The designer methcathinone analogs, mephedrone and methylone, are substrates for monoamine transporters in brain tissue, Neuropsychopharmacology, 37, 1192, 10.1038/npp.2011.304 Bello, 2011, Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors, Nat. Neurosci., 14, 1033, 10.1038/nn.2862 Benoit-Marand, 2001, Inhibition of dopamine release via presynaptic D2 receptors: time course and functional characteristics in vivo, J. Neurosci., 21, 9134, 10.1523/JNEUROSCI.21-23-09134.2001 Benturquia, 2008, Involvement of D1 dopamine receptor in MDMA-induced locomotor activity and striatal gene expression in mice, Brain Res., 1211, 1, 10.1016/j.brainres.2008.03.016 Bilsky, 1991, MDL72222, a serotonin 5-HT3 receptor antagonist, blocks MDMA's ability to establish a conditioned place preference, Pharmacol. Biochem. Behav., 39, 509, 10.1016/0091-3057(91)90217-P Bubar, 2004, Effects of dopamine D1- or D2-like receptor antagonists on the hypermotive and discriminative stimulus effects of (+)-MDMA, Psychopharmacology, 173, 326, 10.1007/s00213-004-1790-1 Cabib, 1991, D1 and D2 receptor antagonists differently affect cocaine-induced locomotor hyperactivity in the mouse, Psychopharmacology, 105, 335, 10.1007/BF02244427 Carhart-Harris, 2011, A web-based survey on mephedrone, Drug Alcohol Depend., 118, 19, 10.1016/j.drugalcdep.2011.02.011 Cole, 2003, The pre-clinical behavioural pharmacology of 3,4-methylenedioxymethamphetamine (MDMA), Neurosci. Biobehav. Rev., 27, 199, 10.1016/S0149-7634(03)00031-9 Cragg, 1997, Differential autoreceptor control of somatodendritic and axon terminal dopamine release in substantia nigra, ventral tegmental area, and striatum, J. Neurosci., 17, 5738, 10.1523/JNEUROSCI.17-15-05738.1997 Cunningham, 1992, Methamphetamine-induced conditioned place preference or aversion depending on dose and presence of drug, Ann. N. Y. Acad. Sci., 654, 431, 10.1111/j.1749-6632.1992.tb25989.x Degenhardt, 2010, Is ecstasy a drug of dependence?, Drug Alcohol Depend., 107, 1, 10.1016/j.drugalcdep.2009.09.009 Diller, 2007, The effects of concurrent administration of +/−3,4-methylenedioxymethamphetamine and cocaine on conditioned place preference in the adult male rat, Pharmacol. Biochem. Behav., 88, 165, 10.1016/j.pbb.2007.07.017 Garrett, 1994, D1 and D2 dopamine receptor antagonists block caffeine-induced stimulation of locomotor activity in rats, Pharmacol. Biochem. Behav., 47, 89, 10.1016/0091-3057(94)90115-5 Gold, 1989, Neurochemical mechanisms involved in behavioral effects of amphetamines and related designer drugs, NIDA Res. Monogr., 94, 101 Hadlock, 2011, 4-Methylmethcathinone(mephedrone): neuropharmacological effects of a designer stimulant of abuse, J. Pharmacol. Exp. Ther., 339, 530, 10.1124/jpet.111.184119 Huang, 2003, Co-administration of dextromethorphan with morphine attenuates morphine rewarding effect and related dopamine releases at the nucleus accumbens, Naunyn Schmiedebergs Arch. Pharmacol., 368, 386, 10.1007/s00210-003-0803-7 Jaworski, 2001, Effect of dopamine D2/D3 receptor antagonist sulpiride on amphetamine-induced changes in striatal extracellular dopamine, Eur. J. Pharmacol., 418, 201, 10.1016/S0014-2999(01)00936-0 Kehr, 2011, Mephedrone, compared to MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and serotonin levels in nucleus accumbens of awake rats, Br. J. Pharmacol., 164, 1949, 10.1111/j.1476-5381.2011.01499.x Leri, 2000, Effects of diazepam on conditioned place preference induced by morphine or amphetamine in the rat, Psychopharmacology, 150, 351, 10.1007/s002130000448 Marona-Lewicka, 1996, Reinforcing effects of certain serotonin-releasing amphetamine derivatives, Pharmacol. Biochem. Behav., 53, 99, 10.1016/0091-3057(95)00205-7 Martínez-Clemente, 2011, Interaction of mephedrone with dopamine and serotonin targets in rats, Eur. Neuropsychopharmacol., 22, 231, 10.1016/j.euroneuro.2011.07.009 Meyer, 2010, Metabolism of designer drugs of abuse: an updated review, Curr. Drug Metab., 11, 468, 10.2174/138920010791526042 Motbey, 2012, Mephedrone (4-methylmethcathinone, ‘meow’): acute behavioural effects and distribution of Fos expression in adolescent rats, Addict. Biol., 17, 409, 10.1111/j.1369-1600.2011.00384.x Newcombe, 2009 Pierce, 1996, Repeated cocaine augments excitatory amino acid transmission in the nucleus accumbens only in rats having developed behavioral sensitization, J. Neurosci., 16, 1550, 10.1523/JNEUROSCI.16-04-01550.1996 Robinson, 2008, The incentive sensitization theory of addiction: some current issues, Philos. Trans. R. Soc. Lond. B: Biol. Sci., 363, 3137, 10.1098/rstb.2008.0093 Ross, 2011, “Bath salts” intoxication, N. Engl. J. Med., 365, 967, 10.1056/NEJMc1107097 Sanchis-Segura, 2006, Behavioural assessment of drug reinforcement and addictive features in rodents: an overview, Addict. Biol., 11, 2, 10.1111/j.1369-1600.2006.00012.x Schifano, 2008, Cocaine/crack cocaine consumption, treatment demand, seizures, related offences, prices, average purity levels and deaths in the UK (1990–2004), J. Psychopharmacol., 22, 71, 10.1177/0269881107079170 Soderman, 2009, Cocaine-induced mu opioid receptor occupancy within the striatum is mediated by dopamine D2 receptors, Brain Res., 1296, 63, 10.1016/j.brainres.2009.08.035 Steketee, 2011, Drug wanting: behavioral sensitization and relapse to drug-seeking behavior, Pharmacol. Rev., 63, 348, 10.1124/pr.109.001933 Stepens, 2008, A Parkinsonian syndrome in methcathinone users and the role of manganese, N. Engl. J. Med., 358, 1009, 10.1056/NEJMoa072488 Ushijima, 1995, Involvement of D1 and D2 dopamine systems in the behavioral effects of cocaine in rats, Pharmacol. Biochem. Behav., 52, 737, 10.1016/0091-3057(95)00167-U Vanattou-Saïfoudine, 2010, Caffeine promotes dopamine D1 receptor-mediated body temperature, heart rate and behavioural responses to MDMA (‘ecstasy’), Psychopharmacology, 211, 15, 10.1007/s00213-010-1864-1 Vanderschuren, 2010, Sensitization processes in drug addiction, Curr. Top. Behav. Neurosci., 3, 179, 10.1007/7854_2009_21 Vezina, 1989, The effect of dopamine receptor blockade on the development of sensitization to the locomotor activating effects of amphetamine and morphine, Brain Res., 499, 108, 10.1016/0006-8993(89)91140-2 Winstock, 2011, Mephedrone, new kid for the chop?, Addiction, 106, 154, 10.1111/j.1360-0443.2010.03130.x Wood, 2010, Case series of individuals with analytically confirmed acute mephedrone toxicity, Clin. Toxicol., 48, 924, 10.3109/15563650.2010.531021