Effect of KRN2391, a Novel Vasodilator, on Various Experimental Anginal Models in Rats

Kingsbury, 1991, The cardiovascular profile of KRN2391 and its congener, in which the nitroxy group is replaced by a hydroxy group, Japan. J. Pharmacol., 55, 255P, 10.1016/S0021-5198(19)39153-X Ogawa, 1993, Flemodynamic profile of KRN2391, a novel vasodilator, in anesthetized dogs, J. Cardiovasc. Pharmacol., 21, 874, 10.1097/00005344-199306000-00005 Ogawa, 1992, Comparative effects of KRN2391 and other coronary vasodilators on cardiovascular system in anesthetized open chest dogs, Arch. Int. Pharmacodyn. Ther., 318, 36 Kishida, 1982, Effects of calcium antagonists, especially nifedipine, on variant angina, resting angina and unstable angina, Japan. Heart J., 23, 871, 10.1536/ihj.23.871 Bassen, 1983, Comparison of the antianginal effectiveness of nifedipine, verapamil, and isosorbide dinitrate in patients receiving propranolol: a doubleblind study, Circulation, 68, 568, 10.1161/01.CIR.68.3.568 Kinoshita, 1986, Comparative efficacy of high-dose versus low-dose nicorandil therapy for chronic stable angina pectoris, Am. J. Cardiol., 58, 733, 10.1016/0002-9149(86)90347-4 Aizawa, 1987, Effects of nicorandil on coronary circulation in patients with ischemic heart disease: comparison with nitroglycerin, J. Cardiovasc. Pharmacol., 10, S123, 10.1097/00005344-198700108-00020 Araki, 1987, Effects of nicorandil on rest effort angina unresponsive to combination therapy with a calcium antagonist and oral nitrate, Clin. Ther., 9, 174 Kato, 1987, Effect of nicorandil on exercise performance in patients with effort angina: a multicenter trial using a treadmill exercise test, J. Cardiovasc. Pharmacol., 10, S98, 10.1097/00005344-198706108-00016 Okada, 1991, An analysis of the nitrate-like and K channel opening action of KRN2391 in canine coronary arterial smooth muscle, Br. J. Pharmacol., 104, 829, 10.1111/j.1476-5381.1991.tb12514.x Fleckenstein, 1977, Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle, Annu. Rev. Pharmacol. Toxicol., 17, 149, 10.1146/annurev.pa.17.040177.001053 Taira, 1987, Similarity and dissimilarity in the mode and mechanism of action between nicorandil and classical nitrates: An overview, J. Cardiovasc. Pharmacol., 10, S1, 10.1097/00005344-198706108-00002 Hiramatsu, 1970, Antagonizing substances obtained from whale heart extract to vasopressin induced myocardial hypoxia, Japan. J. Pharmacol., 20, 313, 10.1254/jjp.20.313 Sakai, 1981, Evaluation of drug effects in a new experimental model of angina pectoris in the intact anesthetized rat, J. Pharmacol. Methods, 3, 139 Haddy, 1969, Physiology and pharmacology of the coronary circulation and myocardium, particularly in relation to coronary artery disease, Am. J. Med., 47, 274, 10.1016/0002-9343(69)90153-3 Braunwald, 1971, Control of myocardial oxygen consumption: Physiologic and clinical considerations, Am. J. Cardiol., 27, 416, 10.1016/0002-9149(71)90439-5 Yasue, 1983, Coronary arterial spasm is ischemic heart disease and its pathogenesis, Circ. Res., 52, 147 Sakai, 1980, Coronary vasoconstriction by locally administered acetylcholine, carbachoi and bethanechol in isolated, donor-perfused rat hearts, Br. J. Pharmacol., 68, 625, 10.1111/j.1476-5381.1980.tb10853.x Sakai, 1980, Pharmacological features of the coronary, renal, mesenteric, and femoral vascular beds of rats revealed by intraarterial administration of drugs, J. Cardiovasc. Pharmacol., 2, 453, 10.1097/00005344-198007000-00012 Taira, 1979, Pharmacological profile of a new coronary vasodilator drug, 2-nicotinamidoethyl nitrate (SG-75), Clin. Exp. Pharmacol. Physiol., 6, 301, 10.1111/j.1440-1681.1979.tb01252.x Gross, 1983, Comparative effects of FR34235, a new slow channel calcium blocker, and nifedipine on hemodynamics and myocardial oxygen consumption in anesthetized dogs, Gen. Pharmacol., 14, 677, 10.1016/0306-3623(83)90167-2 Morrison, 1990, Differential effects of the antianginal drug nicorandil on canine arteries and veins, J. Cardiovasc. Pharmacol., 15, 791, 10.1097/00005344-199005000-00015 Fukata, 1990, Effect of KRN2391, a novel vasodilator, on responses induced by several vasoconstrictors in isolated canine coronary arteries, Japan. J. Pharmacol., 52, 375P, 10.1016/S0021-5198(19)60088-0 Kashiwabara, 1991, Characteristics of KRN2391, a novel vasodilator, compared with those of cromakalim, pinacidil and nifedipine in rat aorta, Eur. J. Pharmacol., 196, 1, 10.1016/0014-2999(91)90401-B Hasenfuss, 1989, Influence of isoproterenol on myocardial energetics. Experimental and clinical investigations, Basic Res. Cardiol., 84, 147, 10.1007/BF02650354 Karasawa, 1988, Antianginal effects of the new calcium antagonist benidipine hydrochloride in anesthetized rats and spontaneously hypertensive rats, Arzneimittelforschung, 38, 1702 Oguro, 1973, Effects of various coronary vasodilators on myocardial oxygen consumption, Japan. J. Pharmacol., 23, 459, 10.1016/S0021-5198(19)31544-6 Toribatake, 1985, Pharmacological studies of a newly synthesized 1,4-dihydropyridine derivative, 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(o-difluoromethoxyphenyl)-1,4-dyhydropyridine (PP-1466), Arzneimittelforschung, 35, 680